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    ROBO2 roundabout guidance receptor 2 [ Homo sapiens (human) ]

    Gene ID: 6092, updated on 17-Jun-2019

    Summary

    Official Symbol
    ROBO2provided by HGNC
    Official Full Name
    roundabout guidance receptor 2provided by HGNC
    Primary source
    HGNC:HGNC:10250
    See related
    Ensembl:ENSG00000185008 MIM:602431
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SAX3
    Summary
    The protein encoded by this gene belongs to the ROBO family, part of the immunoglobulin superfamily of proteins that are highly conserved from fly to human. The encoded protein is a transmembrane receptor for the slit homolog 2 protein and functions in axon guidance and cell migration. Mutations in this gene are associated with vesicoureteral reflux, characterized by the backward flow of urine from the bladder into the ureters or the kidney. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
    Expression
    Broad expression in brain (RPKM 5.1), lung (RPKM 2.8) and 14 other tissues See more
    Orthologs

    Genomic context

    See ROBO2 in Genome Data Viewer
    Location:
    3p12.3
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (75906675..77649964)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (75955845..77699115)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 92, pseudogene Neighboring gene microRNA 4273 Neighboring gene zinc finger protein 717 Neighboring gene uncharacterized LOC107986020 Neighboring gene CAP1 pseudogene 1 Neighboring gene uncharacterized LOC102724949 Neighboring gene RNA, U6 small nuclear 386, pseudogene Neighboring gene voltage dependent anion channel 1 pseudogene 7 Neighboring gene uncharacterized LOC105377171 Neighboring gene RNA, U6 small nuclear 217, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Vesicoureteral reflux 2
    MedGen: C1970483 OMIM: 610878 GeneReviews: Not available
    not available

    NHGRI GWAS Catalog

    Description
    A genome-wide association study of schizophrenia using brain activation as a quantitative phenotype.
    NHGRI GWA Catalog
    Common variation near ROBO2 is associated with expressive vocabulary in infancy.
    NHGRI GWA Catalog
    Genetic variants associated with disordered eating.
    NHGRI GWA Catalog
    Genome-wide association study of chronic periodontitis in a general German population.
    NHGRI GWA Catalog
    Genome-wide association study of circulating estradiol, testosterone, and sex hormone-binding globulin in postmenopausal women.
    NHGRI GWA Catalog
    Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid.
    NHGRI GWA Catalog
    Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
    NHGRI GWA Catalog

    Pathways from BioSystems

    • Axon guidance, organism-specific biosystem (from KEGG)
      Axon guidance, organism-specific biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
    • Axon guidance, conserved biosystem (from KEGG)
      Axon guidance, conserved biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
    • Axon guidance, organism-specific biosystem (from REACTOME)
      Axon guidance, organism-specific biosystemAxon guidance / axon pathfinding is the process by which neurons send out axons to reach the correct targets. Growing axons have a highly motile structure at the growing tip called the growth cone, w...
    • Developmental Biology, organism-specific biosystem (from REACTOME)
      Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
    • Regulation of Commissural axon pathfinding by Slit and Robo, organism-specific biosystem (from REACTOME)
      Regulation of Commissural axon pathfinding by Slit and Robo, organism-specific biosystemCommissural axons project to the floor plate, attracted by the interaction of their DCC receptors with netrin1 produced by floor plate cells. The axons are insensitive to the repulsive action of slit...
    • Signaling by Robo receptor, organism-specific biosystem (from REACTOME)
      Signaling by Robo receptor, organism-specific biosystemThe Roundabout (Robo) family encodes transmembrane receptors that regulate axonal guidance and cell migration. The major function of the Robo receptors is to mediate repulsion of the navigating growt...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA1568

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    axon guidance receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    axon guidance receptor activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    identical protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    aorta development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    aortic valve morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    apoptotic process involved in luteolysis IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    axon guidance ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    axon guidance TAS
    Traceable Author Statement
    more info
     
    axon midline choice point recognition ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    brain development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to hormone stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    central nervous system development NAS
    Non-traceable Author Statement
    more info
    PubMed 
    endocardial cushion formation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    homophilic cell adhesion via plasma membrane adhesion molecules IDA
    Inferred from Direct Assay
    more info
    PubMed 
    metanephros development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of negative chemotaxis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of synapse assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    olfactory bulb interneuron development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    outflow tract septum morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of Notch signaling pathway involved in heart induction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of axonogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    pulmonary valve morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    retinal ganglion cell axon guidance ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    spinal cord development IEA
    Inferred from Electronic Annotation
    more info
     
    ureteric bud development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ventricular septum morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    axolemma ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular exosome HDA PubMed 
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    roundabout homolog 2
    Names
    roundabout, axon guidance receptor, homolog 2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_027734.2 RefSeqGene

      Range
      4982..1748271
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001128929.3NP_001122401.1  roundabout homolog 2 isoform ROBO2a

      See identical proteins and their annotated locations for NP_001122401.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the use of an alternate promoter and has multiple differences compared to variant 4. These differences result in a distinct 5' UTR and the use of an alternate start codon compared to variant 4. The encoded protein (isoform ROBO2a; PMID 16829019) has a distinct N-terminus and is shorter than isoform 4.
      Source sequence(s)
      AC126467, AC133040, DQ533873
      Consensus CDS
      CCDS54609.1
      UniProtKB/Swiss-Prot
      Q9HCK4
      Related
      ENSP00000417335.2, ENST00000487694.7
      Conserved Domains (7) summary
      cd00096
      Location:451518
      Ig; Immunoglobulin domain
      cd05726
      Location:344433
      Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
      cd07693
      Location:46145
      Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
      smart00410
      Location:440521
      IG_like; Immunoglobulin like
      cd00063
      Location:538631
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:241326
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:153237
      Ig; Immunoglobulin domain
    2. NM_001290039.2NP_001276968.1  roundabout homolog 2 isoform 3 precursor

      See identical proteins and their annotated locations for NP_001276968.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 3' coding region compared to variant 4. The encoded protein (isoform 3) is shorter than variant 4.
      Source sequence(s)
      AC117515, AC117516, AC133040, BC144306, DQ533874
      UniProtKB/Swiss-Prot
      Q9HCK4
      Conserved Domains (7) summary
      cd00096
      Location:439506
      Ig; Immunoglobulin domain
      cd05726
      Location:332421
      Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
      cd07693
      Location:30129
      Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
      smart00410
      Location:428509
      IG_like; Immunoglobulin like
      cd00063
      Location:526619
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:225310
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:137221
      Ig; Immunoglobulin domain
    3. NM_001290040.2NP_001276969.1  roundabout homolog 2 isoform 4 precursor

      See identical proteins and their annotated locations for NP_001276969.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) represents the longest transcript and encodes the longest isoform (4).
      Source sequence(s)
      AC117515, AC133040, BC144303, DQ533874
      UniProtKB/Swiss-Prot
      Q9HCK4
      Related
      ENSP00000327536.8, ENST00000332191.12
      Conserved Domains (7) summary
      cd00096
      Location:439506
      Ig; Immunoglobulin domain
      cd05726
      Location:332421
      Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
      cd07693
      Location:30129
      Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
      smart00410
      Location:428509
      IG_like; Immunoglobulin like
      cd00063
      Location:526619
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:225310
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:137221
      Ig; Immunoglobulin domain
    4. NM_001290065.2NP_001276994.1  roundabout homolog 2 isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) has multiple differences compared to variant 4. These differences result in a distinct 5' UTR and cause translation initiation at a downstream start codon compared to variant 4; the 5'-most initiation codon, as used in variant 4, is associated with a truncated ORF that would render the transcript a candidate for nonsense-mediated decay (NMD). Leaky scanning may allow translation initiation at the downstream AUG resulting in an isoform (5) with a shorter N-terminus compared to isoform 4.
      Source sequence(s)
      AC117515, AC133040, BC144302, DQ533874
      UniProtKB/Swiss-Prot
      Q9HCK4
      Conserved Domains (1) summary
      cd00063
      Location:147239
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    5. NM_002942.5NP_002933.1  roundabout homolog 2 isoform ROBO2b precursor

      See identical proteins and their annotated locations for NP_002933.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks two alternate in-frame exons in the coding region compared to variant 4. The encoded protein (isoform ROBO2b; PMID 16829019) is shorter than variant 4.
      Source sequence(s)
      AC117515, AC133040, DQ533874
      Consensus CDS
      CCDS43109.1
      UniProtKB/Swiss-Prot
      Q9HCK4
      Related
      ENSP00000417164.1, ENST00000461745.5
      Conserved Domains (5) summary
      cd05726
      Location:328417
      Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
      cd07693
      Location:30129
      Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
      smart00409
      Location:424505
      IG; Immunoglobulin
      cd00063
      Location:522615
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl11960
      Location:137221
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

      Range
      75906675..77649964
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017006997.1XP_016862486.1  roundabout homolog 2 isoform X16

    2. XM_017007005.1XP_016862494.1  roundabout homolog 2 isoform X25

    3. XM_017006990.1XP_016862479.1  roundabout homolog 2 isoform X8

    4. XM_017006996.1XP_016862485.1  roundabout homolog 2 isoform X15

    5. XM_017006992.1XP_016862481.1  roundabout homolog 2 isoform X10

    6. XM_017007004.1XP_016862493.1  roundabout homolog 2 isoform X24

    7. XM_011533981.2XP_011532283.1  roundabout homolog 2 isoform X1

      See identical proteins and their annotated locations for XP_011532283.1

      Conserved Domains (6) summary
      cd05726
      Location:355444
      Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
      cd07693
      Location:53152
      Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
      smart00409
      Location:451532
      IG; Immunoglobulin
      cd00063
      Location:549642
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam16599
      Location:13741431
      PTN13_u3; Unstructured linker region on PTN13 protein between PDZ
      cl11960
      Location:160244
      Ig; Immunoglobulin domain
    8. XM_017006988.1XP_016862477.1  roundabout homolog 2 isoform X6

    9. XM_017006994.1XP_016862483.1  roundabout homolog 2 isoform X13

    10. XM_017007001.1XP_016862490.1  roundabout homolog 2 isoform X21

    11. XM_017006995.1XP_016862484.1  roundabout homolog 2 isoform X14

    12. XM_011533983.1XP_011532285.1  roundabout homolog 2 isoform X5

      See identical proteins and their annotated locations for XP_011532285.1

      Conserved Domains (7) summary
      cd00096
      Location:462529
      Ig; Immunoglobulin domain
      cd05726
      Location:355444
      Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
      cd07693
      Location:53152
      Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
      smart00410
      Location:451532
      IG_like; Immunoglobulin like
      cd00063
      Location:549642
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:248333
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:160244
      Ig; Immunoglobulin domain
    13. XM_011533984.1XP_011532286.1  roundabout homolog 2 isoform X12

      See identical proteins and their annotated locations for XP_011532286.1

      Conserved Domains (7) summary
      cd00096
      Location:462529
      Ig; Immunoglobulin domain
      cd05726
      Location:355444
      Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
      cd07693
      Location:53152
      Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
      smart00410
      Location:451532
      IG_like; Immunoglobulin like
      cd00063
      Location:549642
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:248333
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:160244
      Ig; Immunoglobulin domain
    14. XM_011533982.1XP_011532284.1  roundabout homolog 2 isoform X3

      See identical proteins and their annotated locations for XP_011532284.1

      Conserved Domains (7) summary
      cd00096
      Location:462529
      Ig; Immunoglobulin domain
      cd05726
      Location:355444
      Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
      cd07693
      Location:53152
      Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
      smart00410
      Location:451532
      IG_like; Immunoglobulin like
      cd00063
      Location:549642
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:248333
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:160244
      Ig; Immunoglobulin domain
    15. XM_017006991.1XP_016862480.1  roundabout homolog 2 isoform X9

    16. XM_011533985.1XP_011532287.1  roundabout homolog 2 isoform X20

      See identical proteins and their annotated locations for XP_011532287.1

      Conserved Domains (7) summary
      cd00096
      Location:462529
      Ig; Immunoglobulin domain
      cd05726
      Location:355444
      Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
      cd07693
      Location:53152
      Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
      smart00410
      Location:451532
      IG_like; Immunoglobulin like
      cd00063
      Location:549642
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:248333
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:160244
      Ig; Immunoglobulin domain
    17. XM_017006987.1XP_016862476.1  roundabout homolog 2 isoform X4

    18. XM_017007002.1XP_016862491.1  roundabout homolog 2 isoform X22

    19. XM_017006989.1XP_016862478.1  roundabout homolog 2 isoform X7

      Conserved Domains (7) summary
      cd00096
      Location:458525
      Ig; Immunoglobulin domain
      cd05726
      Location:351440
      Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
      cd07693
      Location:53152
      Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
      smart00410
      Location:447528
      IG_like; Immunoglobulin like
      cd00063
      Location:545638
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:248333
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:160244
      Ig; Immunoglobulin domain
    20. XM_017007003.1XP_016862492.1  roundabout homolog 2 isoform X23

      Conserved Domains (7) summary
      cd00096
      Location:458525
      Ig; Immunoglobulin domain
      cd05726
      Location:351440
      Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
      cd07693
      Location:53152
      Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
      smart00410
      Location:447528
      IG_like; Immunoglobulin like
      cd00063
      Location:545638
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:248333
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:160244
      Ig; Immunoglobulin domain
    21. XM_017006999.1XP_016862488.1  roundabout homolog 2 isoform X18

    22. XM_017006986.1XP_016862475.1  roundabout homolog 2 isoform X2

      Conserved Domains (7) summary
      cd00096
      Location:439506
      Ig; Immunoglobulin domain
      cd05726
      Location:332421
      Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
      cd07693
      Location:30129
      Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
      smart00410
      Location:428509
      IG_like; Immunoglobulin like
      cd00063
      Location:526619
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:225310
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:137221
      Ig; Immunoglobulin domain
    23. XM_017006998.1XP_016862487.1  roundabout homolog 2 isoform X17

    24. XM_017007006.1XP_016862495.1  roundabout homolog 2 isoform X26

    25. XM_017007000.1XP_016862489.1  roundabout homolog 2 isoform X19

    26. XM_017006993.1XP_016862482.1  roundabout homolog 2 isoform X11

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