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    GAS5 growth arrest specific 5 [ Homo sapiens (human) ]

    Gene ID: 60674, updated on 4-Jun-2019

    Summary

    Official Symbol
    GAS5provided by HGNC
    Official Full Name
    growth arrest specific 5provided by HGNC
    Primary source
    HGNC:HGNC:16355
    See related
    Ensembl:ENSG00000234741 MIM:608280
    Gene type
    ncRNA
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SNHG2; NCRNA00030
    Summary
    This gene produces a spliced long non-coding RNA and is a member of the 5' terminal oligo-pyrimidine class of genes. It is a small nucleolar RNA host gene, containing multiple C/D box snoRNA genes in its introns. Part of the secondary RNA structure of the encoded transcript mimics glucocorticoid response element (GRE) which means it can bind to the DNA binding domain of the glucocorticoid receptor (nuclear receptor subfamily 3, group C, member 1). This action blocks the glucocorticoid receptor from being activated and thereby stops it from regulating the transcription of its target genes. This transcript is also thought to regulate the transcriptional activity of other receptors, such as androgen, progesterone and mineralocorticoid receptors, that can bind to its GRE mimic region. Multiple functions have been associated with this transcript, including cellular growth arrest and apoptosis. It has also been identified as a potential tumor suppressor, with its down-regulation associated with cancer in multiple different tissues. [provided by RefSeq, Mar 2015]
    Expression
    Ubiquitous expression in ovary (RPKM 307.5), thyroid (RPKM 113.4) and 24 other tissues See more
    Orthologs

    Genomic context

    See GAS5 in Genome Data Viewer
    Location:
    1q25.1
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (173863899..173868882, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (173833039..173837125, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene centromere protein L Neighboring gene aspartyl-tRNA synthetase 2, mitochondrial Neighboring gene GAS5 antisense RNA 1 Neighboring gene small nucleolar RNA, C/D box 81 Neighboring gene small nucleolar RNA, C/D box 47 Neighboring gene small nucleolar RNA, H/ACA box 103 Neighboring gene small nucleolar RNA, C/D box 80 Neighboring gene small nucleolar RNA, C/D box 79 Neighboring gene small nucleolar RNA, C/D box 78 Neighboring gene small nucleolar RNA, C/D box 44 Neighboring gene small nucleolar RNA, C/D box 77 Neighboring gene small nucleolar RNA, C/D box 76 Neighboring gene small nucleolar RNA, C/D box 75 Neighboring gene small nucleolar RNA, C/D box 74 Neighboring gene zinc finger and BTB domain containing 37 Neighboring gene serpin family C member 1 Neighboring gene RNA, 5S ribosomal pseudogene 67

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Potential readthrough

    Included gene: CENPL

    Homology

    Other Names

    • growth arrest specific 5 (non-protein coding)
    • growth arrest specific transcript 5
    • small nucleolar RNA host gene (non-protein coding) 2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_002578.3 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL110141, CA441479, DA317412
      Related
      ENST00000450589.5
    2. NR_152521.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL136170
      Related
      ENST00000430245.5
    3. NR_152522.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL136170
    4. NR_152523.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL136170
      Related
      ENST00000448718.5
    5. NR_152524.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL136170
    6. NR_152525.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      BM744461, CA441479, DA317412
    7. NR_152526.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      BM754005, CA441479, DA317412
    8. NR_152527.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      CA441479, CB151926, DA317412
    9. NR_152528.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      CA441479, CD174226, DA317412
    10. NR_152529.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      CA441479, CD175951, DA317412
      Related
      ENST00000449289.5
    11. NR_152530.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      CA441479, CD247817, DA317412
    12. NR_152531.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AV758168, CA441479, DA317412
    13. NR_152532.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      BQ949316, CA441479, DA317412, HY063734
    14. NR_152533.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL136170
    15. NR_152534.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      BM853444, CA441479, DA317412

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

      Range
      173863899..173868882 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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