U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    GPBP1L1 GC-rich promoter binding protein 1 like 1 [ Homo sapiens (human) ]

    Gene ID: 60313, updated on 5-Mar-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    GPBP1L1provided by HGNC
    Official Full Name
    GC-rich promoter binding protein 1 like 1provided by HGNC
    Primary source
    HGNC:HGNC:28843
    See related
    Ensembl:ENSG00000159592 AllianceGenome:HGNC:28843
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SP192
    Summary
    Predicted to enable DNA binding activity and RNA binding activity. Predicted to be involved in regulation of transcription, DNA-templated. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis (RPKM 44.4), thyroid (RPKM 35.1) and 25 other tissues See more
    Orthologs
    mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    1p34.1
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (45627304..45688110, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (45499652..45560916, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (46092976..46152205, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 833 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:46054000-46054500 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:46054501-46055001 Neighboring gene MPRA-validated peak199 silencer Neighboring gene nuclear autoantigenic sperm protein Neighboring gene coiled-coil domain containing 17 Neighboring gene ribosomal protein S15a pseudogene 10 Neighboring gene ribosomal protein L7a pseudogene 16 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:46142481-46142981 Neighboring gene Sharpr-MPRA regulatory region 13545 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:46151821-46152419 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 986 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 987 Neighboring gene transmembrane protein 69 Neighboring gene intracisternal A particle-promoted polypeptide Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 834 Neighboring gene uncharacterized LOC105378693

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Comparative Protein Interaction Network Analysis Identifies Shared and Distinct Functions for the Human ROCO Proteins. Tomkins JE, et al. Proteomics, 2018 May. PMID 29513927, Free PMC Article
    2. The p300/YY1/miR-500a-5p/HDAC2 signalling axis regulates cell proliferation in human colorectal cancer. Tang W, et al. Nat Commun, 2019 Feb 8. PMID 30737378, Free PMC Article
    3. An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. Boldt K, et al. Nat Commun, 2016 May 13. PMID 27173435, Free PMC Article
    4. The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei. Nassa G, et al. Sci Data, 2019 Sep 16. PMID 31527615, Free PMC Article
    5. Substrate-Trapped Interactors of PHD3 and FIH Cluster in Distinct Signaling Pathways. Rodriguez J, et al. Cell Rep, 2016 Mar 22. PMID 26972000, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

    Go to the top of the page Help

    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

    Go to the top of the page Help

    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    vasculin-like protein 1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021639.5 → NP_067652.1  vasculin-like protein 1

      See identical proteins and their annotated locations for NP_067652.1

      Status: VALIDATED

      Source sequence(s)
      BC022218, BC068578, BU627076
      Consensus CDS
      CCDS528.1
      UniProtKB/Swiss-Prot
      D3DQ10, Q9H751, Q9HC44
      Related
      ENSP00000347224.3, ENST00000355105.8
      Conserved Domains (1) summary
      pfam15337
      Location:380 → 459
      Vasculin; Vascular protein family Vasculin-like 1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      45627304..45688110 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047427077.1 → XP_047283033.1  vasculin-like protein 1 isoform X2

    2. XM_024448810.2 → XP_024304578.1  vasculin-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      D3DQ10, Q9H751, Q9HC44
      Conserved Domains (1) summary
      pfam15337
      Location:380 → 459
      Vasculin; Vascular protein family Vasculin-like 1

    3. XM_047427059.1 → XP_047283015.1  vasculin-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      D3DQ10, Q9H751, Q9HC44

    4. XM_047427066.1 → XP_047283022.1  vasculin-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      D3DQ10, Q9H751, Q9HC44

    5. XM_047427070.1 → XP_047283026.1  vasculin-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      D3DQ10, Q9H751, Q9HC44

    6. XM_047427067.1 → XP_047283023.1  vasculin-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      D3DQ10, Q9H751, Q9HC44

    7. XM_047427069.1 → XP_047283025.1  vasculin-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      D3DQ10, Q9H751, Q9HC44

    8. XM_024448808.2 → XP_024304576.1  vasculin-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      D3DQ10, Q9H751, Q9HC44
      Conserved Domains (1) summary
      pfam15337
      Location:380 → 459
      Vasculin; Vascular protein family Vasculin-like 1

    9. XM_047427075.1 → XP_047283031.1  vasculin-like protein 1 isoform X2

    10. XM_024448806.2 → XP_024304574.1  vasculin-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      D3DQ10, Q9H751, Q9HC44
      Conserved Domains (1) summary
      pfam15337
      Location:380 → 459
      Vasculin; Vascular protein family Vasculin-like 1

    11. XM_047427076.1 → XP_047283032.1  vasculin-like protein 1 isoform X2

    12. XM_024448809.2 → XP_024304577.1  vasculin-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      D3DQ10, Q9H751, Q9HC44
      Related
      ENSP00000290795.3, ENST00000290795.7
      Conserved Domains (1) summary
      pfam15337
      Location:380 → 459
      Vasculin; Vascular protein family Vasculin-like 1

    13. XM_017002019.3 → XP_016857508.1  vasculin-like protein 1 isoform X2

    14. XM_047427078.1 → XP_047283034.1  vasculin-like protein 1 isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      45499652..45560916 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054338058.1 → XP_054194033.1  vasculin-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      D3DQ10, Q9H751, Q9HC44

    2. XM_054338057.1 → XP_054194032.1  vasculin-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      D3DQ10, Q9H751, Q9HC44

    3. XM_054338066.1 → XP_054194041.1  vasculin-like protein 1 isoform X2

    4. XM_054338059.1 → XP_054194034.1  vasculin-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      D3DQ10, Q9H751, Q9HC44

    5. XM_054338055.1 → XP_054194030.1  vasculin-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      D3DQ10, Q9H751, Q9HC44

    6. XM_054338056.1 → XP_054194031.1  vasculin-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      D3DQ10, Q9H751, Q9HC44

    7. XM_054338060.1 → XP_054194035.1  vasculin-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      D3DQ10, Q9H751, Q9HC44

    8. XM_054338061.1 → XP_054194036.1  vasculin-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      D3DQ10, Q9H751, Q9HC44

    9. XM_054338064.1 → XP_054194039.1  vasculin-like protein 1 isoform X2

    10. XM_054338062.1 → XP_054194037.1  vasculin-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      D3DQ10, Q9H751, Q9HC44

    11. XM_054338065.1 → XP_054194040.1  vasculin-like protein 1 isoform X2

    12. XM_054338054.1 → XP_054194029.1  vasculin-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      D3DQ10, Q9H751, Q9HC44

    13. XM_054338063.1 → XP_054194038.1  vasculin-like protein 1 isoform X2

    14. XM_054338067.1 → XP_054194042.1  vasculin-like protein 1 isoform X3

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9HC44.1 GenPept UniProtKB/Swiss-Prot:Q9HC44

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous