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    BCL2 BCL2 apoptosis regulator [ Homo sapiens (human) ]

    Gene ID: 596, updated on 21-Jan-2020

    Summary

    Official Symbol
    BCL2provided by HGNC
    Official Full Name
    BCL2 apoptosis regulatorprovided by HGNC
    Primary source
    HGNC:HGNC:990
    See related
    Ensembl:ENSG00000171791 MIM:151430
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Bcl-2; PPP1R50
    Summary
    This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
    Expression
    Broad expression in thyroid (RPKM 21.9), spleen (RPKM 9.1) and 20 other tissues See more
    Orthologs

    Genomic context

    See BCL2 in Genome Data Viewer
    Location:
    18q21.33
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109.20191205 current GRCh38.p13 (GCF_000001405.39) 18 NC_000018.10 (63123346..63320280, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (60790579..60987011, complement)

    Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 4133 Neighboring gene uncharacterized LOC105372161 Neighboring gene 3-ketodihydrosphingosine reductase Neighboring gene proteasome 26S subunit, ATPase 5 pseudogene Neighboring gene vacuolar protein sorting 4 homolog B

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    NHGRI GWAS Catalog

    Description
    Association of genome-wide variation with highly sensitive cardiac troponin-T levels in European Americans and Blacks: a meta-analysis from atherosclerosis risk in communities and cardiovascular health studies.
    NHGRI GWA Catalog
    Genome-wide Association Study Identifies Five Susceptibility Loci for Follicular Lymphoma outside the HLA Region.
    NHGRI GWA Catalog
    Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia.
    NHGRI GWA Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Treatment of monocyte-derived dendritic cells with HIV-1 gp120 downregulates the expression of the anti-apoptotic molecules BCL-2 and BCL-xL PubMed
    env Binding of HIV-1 gp120 to CD4 downregulates Bcl-2 protein in CD4+ T lymphocytes and facilitates Fas/Fas-ligand triggered apoptosis; addition of IL-2 rescues CD4+ T cells from CD4/gp120-induced Bcl-2 down modulation and apoptosis induction PubMed
    env Binding of HIV-1 envelope protein gp120 to CD4 downregulates Bcl-2 expression; this effect is inhibited by gp17/GCDFP-15, which blocks the ability of CD4 to interact with gp120, leading to moderate up-regulation of Bcl-2 PubMed
    Envelope surface glycoprotein gp160, precursor env HIV-1 gp160-induced apoptosis is affected in part by the release of TNF-alpha and is associated with attenuated Bcl-2 mRNA expression PubMed
    Nef nef Recombinant HIV-1 Nef upregulates expression of antiapoptotic proteins BCL2, AKT1, and XIAP in THP-1 cells and primary blood macrophages PubMed
    nef HIV-1 Nef enhances apoptosis in CD4+ human lymphoblastoid cell lines through mechanisms that include the downregulation of the anti-apoptotic proteins Bcl-2 and Bcl-XL PubMed
    Tat tat HIV-1 Tat induces apoptosis of human blood-retinal barrier-associated cells by downregulation of BCL2 and upregulation of BAK, BAX, and cytochrome c in a dose-dependent manner PubMed
    tat HIV-1 clade B and C Tat downregulate the expression of BCL2 in primary glia PubMed
    tat HIV-1 Tat inhibits IL7-induced upregulation of BCL-2 in CD4 T-cells PubMed
    tat HIV-1 Tat upregulates Bcl-2 expression in a variety of cell types (PBMC, MDM, Jurkat, HeLa, etc.), an effect that is linked to the ability of Tat to inhibit apoptosis PubMed
    tat HIV-1 Tat modulates BCL2 expression in neuron cells PubMed
    tat FasL-induced cleavage of BID/p22 and BCL-2 proteins is inhibited in HIV-1 Tat101-expressing Jurkat cells PubMed
    tat PDGF-BB protects neurons against HIV-1 Tat and morphine-induced apoptosis by promoting Bcl2 and inhibiting Bax expression PubMed
    tat HIV-1 Tat-induced apoptosis through increased expression of anti-apoptotic protein Bcl-2, proapoptotic protein Bax and activation of caspases CASP3 and CASP9 is inhibited by estrogen receptor beta (ER)-mediated estrogen treatment PubMed
    tat Expression of HIV-1 Tat in hematopoietic cells results in downregulation of Bcl-2 and induction of apoptosis PubMed
    tat Tat-expressing EBV-positive B cells show downregulation of Bcl-2, and in serum starvation conditions display the Retinoblastoma (Rb) hyper-phosphorylated form, progress throughout the cell cycle, and retain the ability to grow in small clumps PubMed
    tat A fusion protein between HIV-1 Tat and a Bcl-2 construct with the loop domain deleted (TAT-Bcl-2Deltaloop) binds to neural cell and rat brain mitochondria to increase the survival of cortical neurons PubMed
    tat Tumor protein p73 interferes with Tat-mediated apoptosis by preventing the up-regulation of Bax and down-regulation of Bcl-2 proteins in astrocytes PubMed
    Vpr vpr Treatment of human PBMCs with HIV-1 Vpr peptide (amino acids 52-96) significantly downregulates expression of Bcl-2 PubMed
    vpr Constitutive expression of HIV-1 Vpr in Jurkat cells or transgenic mice resulted in upregulation of Bcl-2, providing evidence for the role of Vpr in the regulation of apoptosis during HIV-1 replication PubMed
    vpr Bcl-2 inhibits or reduces HIV-1 Vpr mediated cytotoxicity, induction of mitochondrial membrane permeabilization and apoptosis PubMed
    retropepsin gag-pol Protein/protein interactions of virus/autophagy-associated proteins by yeast two-hybrid array reveals the interaction between HIV-1 PR and BCL2 PubMed
    gag-pol Purified bcl-2 is cleaved by HIV-1 protease between phenylalanine 112 and alanine 113 PubMed
    gag-pol HIV-1 protease depletes infected cells of bcl-2, leading to oxidative stress-dependent activation of NF kappa B, a cellular factor required for HIV transcription, and ultimately to cell death PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    BH3 domain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    channel inhibitor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protease binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein heterodimerization activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein phosphatase 2A binding IEA
    Inferred from Electronic Annotation
    more info
     
    repressing transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    B cell homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    B cell lineage commitment IEA
    Inferred from Electronic Annotation
    more info
     
    B cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    B cell receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    CD8-positive, alpha-beta T cell lineage commitment IEA
    Inferred from Electronic Annotation
    more info
     
    T cell differentiation in thymus IEA
    Inferred from Electronic Annotation
    more info
     
    T cell homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    actin filament organization IEA
    Inferred from Electronic Annotation
    more info
     
    apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    axon regeneration IEA
    Inferred from Electronic Annotation
    more info
     
    axonogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    behavioral fear response IEA
    Inferred from Electronic Annotation
    more info
     
    branching involved in ureteric bud morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    cell aging IEA
    Inferred from Electronic Annotation
    more info
     
    cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to DNA damage stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to glucose starvation IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to hypoxia IEA
    Inferred from Electronic Annotation
    more info
     
    cochlear nucleus development IEA
    Inferred from Electronic Annotation
    more info
     
    cytokine-mediated signaling pathway TAS
    Traceable Author Statement
    more info
     
    defense response to virus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    digestive tract morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    ear development IEA
    Inferred from Electronic Annotation
    more info
     
    endoplasmic reticulum calcium ion homeostasis TAS
    Traceable Author Statement
    more info
    PubMed 
    extrinsic apoptotic signaling pathway in absence of ligand IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    extrinsic apoptotic signaling pathway via death domain receptors IDA
    Inferred from Direct Assay
    more info
    PubMed 
    female pregnancy NAS
    Non-traceable Author Statement
    more info
    PubMed 
    focal adhesion assembly IEA
    Inferred from Electronic Annotation
    more info
     
    gland morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    glomerulus development IEA
    Inferred from Electronic Annotation
    more info
     
    hair follicle morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    homeostasis of number of cells within a tissue IEA
    Inferred from Electronic Annotation
    more info
     
    humoral immune response TAS
    Traceable Author Statement
    more info
    PubMed 
    intrinsic apoptotic signaling pathway in response to DNA damage IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intrinsic apoptotic signaling pathway in response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
     
    lymphoid progenitor cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    male gonad development IEA
    Inferred from Electronic Annotation
    more info
     
    melanin metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    melanocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    mesenchymal cell development IEA
    Inferred from Electronic Annotation
    more info
     
    metanephros development IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of G1/S transition of mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of anoikis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of apoptotic process TAS
    Traceable Author Statement
    more info
     
    negative regulation of apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of autophagy TAS
    Traceable Author Statement
    more info
    PubMed 
    negative regulation of calcium ion transport into cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cell growth IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cellular pH reduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of intrinsic apoptotic signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of intrinsic apoptotic signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator TAS
    Traceable Author Statement
    more info
    PubMed 
    negative regulation of mitochondrial depolarization TAS
    Traceable Author Statement
    more info
    PubMed 
    negative regulation of myeloid cell apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of neuron apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of ossification IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of osteoblast proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of reactive oxygen species metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of retinal cell programmed cell death IEA
    Inferred from Electronic Annotation
    more info
     
    neuron apoptotic process TAS
    Traceable Author Statement
    more info
    PubMed 
    oocyte development IEA
    Inferred from Electronic Annotation
    more info
     
    organ growth IEA
    Inferred from Electronic Annotation
    more info
     
    ossification IEA
    Inferred from Electronic Annotation
    more info
     
    ovarian follicle development IEA
    Inferred from Electronic Annotation
    more info
     
    peptidyl-serine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    peptidyl-threonine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    pigment granule organization IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of B cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell growth IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of intrinsic apoptotic signaling pathway TAS
    Traceable Author Statement
    more info
     
    positive regulation of melanocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of multicellular organism growth IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of neuron maturation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of peptidyl-serine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway TAS
    Traceable Author Statement
    more info
     
    positive regulation of skeletal muscle fiber development IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of smooth muscle cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    post-embryonic development IEA
    Inferred from Electronic Annotation
    more info
     
    protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    protein polyubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    reactive oxygen species metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of calcium ion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of cell-matrix adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of glycoprotein biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of mitochondrial membrane permeability ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    regulation of mitochondrial membrane potential ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    regulation of nitrogen utilization IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of protein heterodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of protein stability IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of viral genome replication IEA
    Inferred from Electronic Annotation
    more info
     
    release of cytochrome c from mitochondria ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    release of cytochrome c from mitochondria NAS
    Non-traceable Author Statement
    more info
    PubMed 
    renal system process IEA
    Inferred from Electronic Annotation
    more info
     
    response to UV-B IEA
    Inferred from Electronic Annotation
    more info
     
    response to cytokine IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to drug IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to drug IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to gamma radiation IEA
    Inferred from Electronic Annotation
    more info
     
    response to glucocorticoid IEA
    Inferred from Electronic Annotation
    more info
     
    response to hydrogen peroxide IEA
    Inferred from Electronic Annotation
    more info
     
    response to iron ion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to ischemia IEA
    Inferred from Electronic Annotation
    more info
     
    response to nicotine IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to radiation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    response to toxic substance IDA
    Inferred from Direct Assay
    more info
    PubMed 
    spleen development IEA
    Inferred from Electronic Annotation
    more info
     
    thymus development IEA
    Inferred from Electronic Annotation
    more info
     
    transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cell IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrial outer membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitochondrial outer membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrial outer membrane TAS
    Traceable Author Statement
    more info
     
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    myelin sheath IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    pore complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein-containing complex IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 

    General protein information

    Preferred Names
    apoptosis regulator Bcl-2
    Names
    B-cell CLL/lymphoma 2
    protein phosphatase 1, regulatory subunit 50

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_009361.1 RefSeqGene

      Range
      5001..201035
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000633.2NP_000624.2  apoptosis regulator Bcl-2 isoform alpha

      See identical proteins and their annotated locations for NP_000624.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (alpha) represents the longer transcript and encodes the longer isoform (alpha).
      Source sequence(s)
      AC021803, AC022726, BC027258
      Consensus CDS
      CCDS11981.1
      UniProtKB/Swiss-Prot
      P10415
      UniProtKB/TrEMBL
      A0A024R2B3
      Related
      ENSP00000329623.3, ENST00000333681.5
      Conserved Domains (1) summary
      TIGR00865
      Location:1239
      bcl-2; apoptosis regulator
    2. NM_000657.2NP_000648.2  apoptosis regulator Bcl-2 isoform beta

      See identical proteins and their annotated locations for NP_000648.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (beta) differs in the 3' UTR and coding region compared to variant alpha. The resulting isoform (beta) is shorter and has a distinct C-terminus compared to isoform alpha.
      Source sequence(s)
      AC021803, AI401297
      Consensus CDS
      CCDS45882.1
      UniProtKB/Swiss-Prot
      P10415
      UniProtKB/TrEMBL
      A0A024R2C4
      Related
      ENSP00000466417.1, ENST00000589955.2
      Conserved Domains (1) summary
      TIGR00865
      Location:1195
      bcl-2; apoptosis regulator

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000018.10 Reference GRCh38.p13 Primary Assembly

      Range
      63123346..63320280 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017025917.2XP_016881406.1  apoptosis regulator Bcl-2 isoform X2

    2. XM_011526135.3XP_011524437.1  apoptosis regulator Bcl-2 isoform X1

      Conserved Domains (3) summary
      smart00265
      Location:733
      BH4; BH4 Bcl-2 homology region 4
      cd06845
      Location:86201
      Bcl-2_like; Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane ...
      TIGR00865
      Location:1203
      bcl-2; apoptosis regulator

    RNA

    1. XR_935248.3 RNA Sequence

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