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    RBMY1A1 RNA binding motif protein Y-linked family 1 member A1 [ Homo sapiens (human) ]

    Gene ID: 5940, updated on 11-Jun-2021

    Summary

    Official Symbol
    RBMY1A1provided by HGNC
    Official Full Name
    RNA binding motif protein Y-linked family 1 member A1provided by HGNC
    Primary source
    HGNC:HGNC:9912
    See related
    Ensembl:ENSG00000234414 MIM:400006
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RBM; RBM1; RBM2; RBMY; YRRM1; YRRM2; RBMY1C
    Summary
    This gene encodes a protein containing an RNA-binding motif in the N-terminus and four SRGY (serine, arginine, glycine, tyrosine) boxes in the C-terminus. This protein is thought to function as a splicing regulator during spermatogenesis. Multiple closely related paralogs of this gene are found in a gene cluster in the AZFb azoospermia factor region of chromosome Y. Most of these related copies are thought to be pseudogenes, though several likely encode functional proteins. [provided by RefSeq, Mar 2016]
    Expression
    Restricted expression toward testis (RPKM 10.4) See more
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    Genomic context

    See RBMY1A1 in Genome Data Viewer
    Location:
    Yq11.223
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) Y NC_000024.10 (21534879..21559683)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) Y NC_000024.9 (23696765..23711212)

    Chromosome Y - NC_000024.10Genomic Context describing neighboring genes Neighboring gene RNA binding motif protein Y-linked family 1 member H, pseudogene Neighboring gene RNA binding motif protein Y-linked family 1 member B Neighboring gene testis-specific transcript, Y-linked 13 Neighboring gene elongin C pseudogene 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Vpu vpu HIV-1 Vpu is identified to have a physical interaction with RNA binding motif protein, Y-linked, family 1, member A1 (RBMY1A1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC181956

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in alternative mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of alternative mRNA splicing, via spliceosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in nuclear speck IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    RNA-binding motif protein, Y chromosome, family 1 member A1
    Names
    RNA-binding motif protein 2
    RNA-binding motif protein, Y chromosome, family 1 member A1/C
    Y chromosome RNA recognition motif 1
    Y chromosome RNA recognition motif 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_004832.1 

      Range
      224219..238666
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    2. NG_012805.1 RefSeqGene

      Range
      4967..19414
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001320944.2NP_001307873.1  RNA-binding motif protein, Y chromosome, family 1 member A1 isoform 2

      Status: REVIEWED

      Source sequence(s)
      BC070298, BX119894, CB107177
      UniProtKB/Swiss-Prot
      P0DJD3
      Conserved Domains (3) summary
      COG0724
      Location:1189
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12382
      Location:785
      RRM_RBMX_like; RNA recognition motif in heterogeneous nuclear ribonucleoprotein G (hnRNP G), Y chromosome RNA recognition motif 1 (hRBMY), testis-specific heterogeneous nuclear ribonucleoprotein G-T (hnRNP G-T) and similar proteins
      pfam08081
      Location:174218
      RBM1CTR; RBM1CTR (NUC064) family
    2. NM_001320945.2NP_001307874.1  RNA-binding motif protein, Y chromosome, family 1 member A1 isoform 3

      Status: REVIEWED

      Source sequence(s)
      BC047768, CB107177
      UniProtKB/Swiss-Prot
      P0DJD3
      Conserved Domains (1) summary
      pfam08081
      Location:3478
      RBM1CTR; RBM1CTR (NUC064) family
    3. NM_005058.4NP_005049.1  RNA-binding motif protein, Y chromosome, family 1 member A1 isoform 1

      See identical proteins and their annotated locations for NP_005049.1

      Status: REVIEWED

      Source sequence(s)
      BX119894, CB107177, X76059
      Consensus CDS
      CCDS14796.1
      UniProtKB/Swiss-Prot
      P0DJD3
      Related
      ENSP00000372154.2, ENST00000382707.6
      Conserved Domains (3) summary
      COG0724
      Location:1189
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12382
      Location:785
      RRM_RBMX_like; RNA recognition motif in heterogeneous nuclear ribonucleoprotein G (hnRNP G), Y chromosome RNA recognition motif 1 (hRBMY), testis-specific heterogeneous nuclear ribonucleoprotein G-T (hnRNP G-T) and similar proteins
      pfam08081
      Location:174218
      RBM1CTR; RBM1CTR (NUC064) family

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000024.10 Reference GRCh38.p13 Primary Assembly

      Range
      21534879..21559683
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011531437.2XP_011529739.1  RNA-binding motif protein, Y chromosome, family 1 member A1 isoform X1

      Conserved Domains (4) summary
      PHA02896
      Location:247362
      PHA02896; A-type inclusion like protein; Provisional
      COG0724
      Location:1189
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12382
      Location:785
      RRM_RBMX_like; RNA recognition motif in heterogeneous nuclear ribonucleoprotein G (hnRNP G), Y chromosome RNA recognition motif 1 (hRBMY), testis-specific heterogeneous nuclear ribonucleoprotein G-T (hnRNP G-T) and similar proteins
      pfam08081
      Location:174218
      RBM1CTR; RBM1CTR (NUC064) family
    2. XM_017030060.1XP_016885549.1  RNA-binding motif protein, Y chromosome, family 1 member A1 isoform X2

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