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    UBL5 ubiquitin like 5 [ Homo sapiens (human) ]

    Gene ID: 59286, updated on 2-May-2024

    Summary

    Official Symbol
    UBL5provided by HGNC
    Official Full Name
    ubiquitin like 5provided by HGNC
    Primary source
    HGNC:HGNC:13736
    See related
    Ensembl:ENSG00000198258 MIM:606849; AllianceGenome:HGNC:13736
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HUB1
    Summary
    This gene encodes a member of a group of proteins similar to ubiquitin. The encoded protein is not thought to degrade proteins like ubiquitin but to affect their function through being bound to target proteins by an isopeptide bond. The gene product has been studied as a link to predisposition to obesity based on its expression in Psammomys obesus, the fat sand rat, which is an animal model for obesity studies. Variation in this gene was found to be significantly associated with some metabolic traits (PMID: 15331561) but not associated with childhood obesity (PMID: 19189687). Pseudogenes of this gene are located on chromosomes 3, 5 and 17. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2013]
    Expression
    Ubiquitous expression in kidney (RPKM 86.7), adrenal (RPKM 83.4) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See UBL5 in Genome Data Viewer
    Location:
    19p13.2
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (9827918..9830115)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (9953519..9956279)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (9938594..9940791)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA70 Neighboring gene ribosomal protein L10 pseudogene 15 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:9938176-9938900 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10047 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10048 Neighboring gene PIN1 divergent transcript Neighboring gene peptidylprolyl cis/trans isomerase, NIMA-interacting 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:9958151-9958702 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:9958703-9959252

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ46917, MGC131795

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein tag activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in Cajal body IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    ubiquitin-like protein 5
    Names
    beacon
    testicular tissue protein Li 217

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001048241.3NP_001041706.1  ubiquitin-like protein 5

      See identical proteins and their annotated locations for NP_001041706.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      BC110839, BP213482, CA418471
      Consensus CDS
      CCDS12219.1
      UniProtKB/Swiss-Prot
      Q2NL89, Q9BZL1
      UniProtKB/TrEMBL
      A0A024R7B0, B2R4N3
      Related
      ENSP00000468656.1, ENST00000586895.6
      Conserved Domains (1) summary
      cd01791
      Location:171
      Ubl_UBL5; ubiquitin-like (Ubl) domain found in ubiquitin-like protein 5 (UBL5) and similar proteins
    2. NM_024292.4NP_077268.1  ubiquitin-like protein 5

      See identical proteins and their annotated locations for NP_077268.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK128885, BC007053, CA418471
      Consensus CDS
      CCDS12219.1
      UniProtKB/Swiss-Prot
      Q2NL89, Q9BZL1
      UniProtKB/TrEMBL
      A0A024R7B0, B2R4N3
      Related
      ENSP00000351492.2, ENST00000358666.7
      Conserved Domains (1) summary
      cd01791
      Location:171
      Ubl_UBL5; ubiquitin-like (Ubl) domain found in ubiquitin-like protein 5 (UBL5) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      9827918..9830115
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      9953519..9956279
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054321656.1XP_054177631.1  ubiquitin-like protein 5 isoform X1

      UniProtKB/Swiss-Prot
      Q2NL89, Q9BZL1
      UniProtKB/TrEMBL
      A0A024R7B0