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    EVA1C eva-1 homolog C [ Homo sapiens (human) ]

    Gene ID: 59271, updated on 23-Nov-2021

    Summary

    Official Symbol
    EVA1Cprovided by HGNC
    Official Full Name
    eva-1 homolog Cprovided by HGNC
    Primary source
    HGNC:HGNC:13239
    See related
    Ensembl:ENSG00000166979
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    B18; B19; SUE21; PRED34; FAM176C; C21orf63; C21orf64
    Expression
    Ubiquitous expression in prostate (RPKM 3.9), gall bladder (RPKM 3.7) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See EVA1C in Genome Data Viewer
    Location:
    21q22.11
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    109.20211119 current GRCh38.p13 (GCF_000001405.39) 21 NC_000021.9 (32411692..32515387)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (33784031..33887697)

    Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene URB1 ribosome biogenesis homolog Neighboring gene Sharpr-MPRA regulatory region 9918 Neighboring gene small nucleolar RNA, H/ACA box 80A Neighboring gene URB1 antisense RNA 1 (head to head) Neighboring gene histone demethylase UTY-like Neighboring gene exosome component 3 pseudogene 1 Neighboring gene CFAP298-TCP10L readthrough Neighboring gene RNA, 5S ribosomal pseudogene 490 Neighboring gene t-complex 10 like

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables heparin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables heparin binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
     
    Component Evidence Code Pubs
    colocalizes_with extracellular region IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    colocalizes_with extracellular region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    protein eva-1 homolog C
    Names
    family with sequence similarity 176, member C
    protein FAM176C

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001286556.2NP_001273485.1  protein eva-1 homolog C isoform 2 precursor

      See identical proteins and their annotated locations for NP_001273485.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate, in-frame donor splice site in the 3' coding region compared to variant 1. The resulting shorter isoform (2) lacks a 3 aa segment compared to isoform 1.
      Source sequence(s)
      AY358787, BC038710, BU175692
      Consensus CDS
      CCDS68186.1
      UniProtKB/Swiss-Prot
      P58658
      Related
      ENSP00000372146.3, ENST00000382699.7
      Conserved Domains (2) summary
      pfam02140
      Location:75158
      Gal_Lectin; Galactose binding lectin domain
      pfam14851
      Location:298438
      FAM176; FAM176 family
    2. NM_001320744.2NP_001307673.1  protein eva-1 homolog C isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks two alternate, in-frame exons in the 5' coding region compared to variant 1. It encodes isoform 3, which is shorter than isoform 1.
      Source sequence(s)
      AP000269, AP000270, AP000271, AP000272
      Conserved Domains (2) summary
      pfam02140
      Location:69152
      Gal_Lectin; Galactose binding lectin domain
      pfam14851
      Location:194334
      FAM176; FAM176 family
    3. NM_001320745.2NP_001307674.1  protein eva-1 homolog C isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) has an alternate 5' -terminal exon, which results in a different 5' UTR and use of a downstream start AUG compared to variant 1. It encodes isoform 4, which has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AP000269, AW957938, BM836911, CA412371
      UniProtKB/TrEMBL
      B3KWG0
      Conserved Domains (2) summary
      pfam02140
      Location:81164
      Gal_Lectin; Galactose binding lectin domain
      pfam14851
      Location:206346
      FAM176; FAM176 family
    4. NM_058187.5NP_478067.2  protein eva-1 homolog C isoform 1 precursor

      See identical proteins and their annotated locations for NP_478067.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript and encodes the longer isoform (1).
      Source sequence(s)
      AY358787, BC038710, BU175692
      Consensus CDS
      CCDS13614.1
      UniProtKB/Swiss-Prot
      P58658
      Related
      ENSP00000300255.2, ENST00000300255.7
      Conserved Domains (2) summary
      pfam02140
      Location:75158
      Gal_Lectin; Galactose binding lectin domain
      pfam14851
      Location:301441
      FAM176; FAM176 family

    RNA

    1. NR_104472.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an exon in the 5' region compared to variant 1. It is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders this transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AY040087, AY358787, BC038710, BU175692
      Related
      ENST00000437338.5
    2. NR_135467.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) uses an alternate splice site at an internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AP000269, AP000272, BM836911, BX342316, CA412371

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000021.9 Reference GRCh38.p13 Primary Assembly

      Range
      32411692..32515387
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017028421.1XP_016883910.1  protein eva-1 homolog C isoform X7

    2. XM_024452125.1XP_024307893.1  protein eva-1 homolog C isoform X6

      Conserved Domains (2) summary
      pfam02140
      Location:80163
      Gal_Lectin; Galactose binding lectin domain
      pfam14851
      Location:205345
      FAM176; FAM176 family
    3. XM_024452126.1XP_024307894.1  protein eva-1 homolog C isoform X8

      Conserved Domains (2) summary
      pfam02140
      Location:80163
      Gal_Lectin; Galactose binding lectin domain
      pfam14851
      Location:202342
      FAM176; FAM176 family
    4. XM_017028420.1XP_016883909.1  protein eva-1 homolog C isoform X5

      UniProtKB/TrEMBL
      B3KWG0
      Conserved Domains (2) summary
      pfam02140
      Location:81164
      Gal_Lectin; Galactose binding lectin domain
      pfam14851
      Location:206346
      FAM176; FAM176 family
    5. XM_017028419.1XP_016883908.1  protein eva-1 homolog C isoform X3

    6. XM_005261019.4XP_005261076.1  protein eva-1 homolog C isoform X4

      Conserved Domains (2) summary
      pfam02140
      Location:75158
      Gal_Lectin; Galactose binding lectin domain
      pfam14851
      Location:254384
      FAM176; FAM176 family
    7. XM_006724038.3XP_006724101.1  protein eva-1 homolog C isoform X2

      Conserved Domains (2) summary
      pfam02140
      Location:75158
      Gal_Lectin; Galactose binding lectin domain
      pfam14851
      Location:300440
      FAM176; FAM176 family
    8. XM_017028418.1XP_016883907.1  protein eva-1 homolog C isoform X1

    9. XM_017028422.1XP_016883911.1  protein eva-1 homolog C isoform X9

    10. XM_017028423.1XP_016883912.1  protein eva-1 homolog C isoform X10

    11. XM_011529669.3XP_011527971.1  protein eva-1 homolog C isoform X5

      See identical proteins and their annotated locations for XP_011527971.1

      UniProtKB/TrEMBL
      B3KWG0
      Conserved Domains (2) summary
      pfam02140
      Location:81164
      Gal_Lectin; Galactose binding lectin domain
      pfam14851
      Location:206346
      FAM176; FAM176 family

    RNA

    1. XR_001754885.1 RNA Sequence

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