Cacnb4 calcium voltage-gated channel auxiliary subunit beta 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cacnb4provided by RGD
Official Full Name: calcium voltage-gated channel auxiliary subunit beta 4provided by RGD
Primary source: RGD:68385
See related: Ensembl:ENSRNOG00000007666 AllianceGenome:RGD:68385
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: CAB4
Summary: Enables protein kinase binding activity and voltage-gated calcium channel activity. Involved in several processes, including negative regulation of G1/S transition of mitotic cell cycle; positive regulation of protein localization to nucleolus; and positive regulation of voltage-gated calcium channel activity. Located in nuclear speck. Is active in presynapse. Human ortholog(s) of this gene implicated in dilated cardiomyopathy; episodic ataxia; episodic ataxia type 5; and generalized epilepsy. Orthologous to human CACNB4 (calcium voltage-gated channel auxiliary subunit beta 4). [provided by Alliance of Genome Resources, Jun 2025]
Expression: Biased expression in Brain (RPKM 254.9), Kidney (RPKM 57.2) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 3q12

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (57315900..57578271, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (36906771..37169165, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (37950846..38211478, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study demonstrated that the beta4 subunit of Cav1.2 channels can act as an antiviral agent; overexpression of beta4 increased the amounts of four key antiviral proteins, namely, DDX58, IRF7, IFITM3, and STAT2, and contrasting results were obtained by silencing beta4.
Title: The β(4) subunit of Ca(v)1.2 channels is required for an optimal interferon response in cardiac muscle cells.
beta4 subunit of the voltage-gated calcium channel (Cacnb4) regulates the rate of cell proliferation in Chinese Hamster Ovary cells
Title: The β(4) subunit of the voltage-gated calcium channel (Cacnb4) regulates the rate of cell proliferation in Chinese Hamster Ovary cells.
analysis of calcium channel beta4b subunit nuclear targeting in nerve and muscle cells
Title: Activity and calcium regulate nuclear targeting of the calcium channel beta4b subunit in nerve and muscle cells.
neither Ca(V)beta3 nor Ca(V)beta4 are indispensable for hair cell Ca(2+) currents but contribute to the overall current properties
Title: Ba2+ currents in inner and outer hair cells of mice lacking the voltage-dependent Ca2+ channel subunits beta3 or beta4.
calcium channel beta 4 subunits affect the conductance of L-type calcium channels; native hippocampal L-type channels contain the beta 4 subunit
Title: The neuronal beta 4 subunit increases the unitary conductance of L-type voltage-gated calcium channels in PC12 cells.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH131012 (e-PCR)
- UniSTS:214295

BF391063 (e-PCR)
- UniSTS:249739

NoName (e-PCR)
- UniSTS:482288

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium channel regulator activity	ISO Inferred from Sequence Orthology more info
enables high voltage-gated calcium channel activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to high voltage-gated calcium channel activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IDA Inferred from Direct Assay more info	PubMed
contributes_to voltage-gated calcium channel activity	IEA Inferred from Electronic Annotation more info
enables voltage-gated calcium channel activity	IEA Inferred from Electronic Annotation more info
enables voltage-gated calcium channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
contributes_to voltage-gated calcium channel activity	ISO Inferred from Sequence Orthology more info
enables voltage-gated calcium channel activity	ISO Inferred from Sequence Orthology more info
enables voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels	IEA Inferred from Electronic Annotation more info
enables voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Peyer's patch development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within Peyer's patch development	ISO Inferred from Sequence Orthology more info
NOT acts_upstream_of_or_within T cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within T cell receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within T cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within adult walking behavior	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within adult walking behavior	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cAMP metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cAMP metabolic process	ISO Inferred from Sequence Orthology more info
involved_in calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in calcium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in calcium ion transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within calcium ion transport	IEA Inferred from Electronic Annotation more info
involved_in calcium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within calcium ion transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to leukemia inhibitory factor	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to leukemia inhibitory factor	ISO Inferred from Sequence Orthology more info
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within detection of light stimulus involved in visual perception	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within detection of light stimulus involved in visual perception	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within gamma-aminobutyric acid secretion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within gamma-aminobutyric acid secretion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within gamma-aminobutyric acid signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within gamma-aminobutyric acid signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within muscle cell development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within muscle cell development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of G1/S transition of mitotic cell cycle	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within nervous system process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within nervous system process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuromuscular junction development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neuromuscular junction development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuronal action potential propagation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neuronal action potential propagation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to nucleolus	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of voltage-gated calcium channel activity	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of membrane potential	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of membrane potential	ISO Inferred from Sequence Orthology more info
involved_in regulation of presynaptic cytosolic calcium ion concentration	IEA Inferred from Electronic Annotation more info
involved_in regulation of synaptic vesicle exocytosis	IEA Inferred from Electronic Annotation more info
involved_in regulation of synaptic vesicle exocytosis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within spleen development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within spleen development	ISO Inferred from Sequence Orthology more info
NOT acts_upstream_of_or_within synaptic transmission, GABAergic	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within synaptic transmission, glutamatergic	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within synaptic transmission, glutamatergic	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within thymus development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within thymus development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in presynapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in synapse	IEA Inferred from Electronic Annotation more info
located_in synapse	ISO Inferred from Sequence Orthology more info
part_of voltage-gated calcium channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of voltage-gated calcium channel complex	IEA Inferred from Electronic Annotation more info
part_of voltage-gated calcium channel complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: voltage-dependent L-type calcium channel subunit beta-4

Names: calcium channel beta 4 subunit; calcium channel voltage-dependent subunit beta 4; calcium channel, voltage-dependent, beta 4 subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001105733.3 → NP_001099203.1 voltage-dependent L-type calcium channel subunit beta-4 isoform 2

See identical proteins and their annotated locations for NP_001099203.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

A0A8L2QRB5

Related

ENSRNOP00000078900.2, ENSRNOT00000101829.2

Conserved Domains (3) summary

cd12043
Location:57 → 124

SH3_CACNB4; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta4

pfam00625
Location:184 → 364

Guanylate_kin; Guanylate kinase

pfam12052
Location:16 → 57

VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal
NM_001399143.2 → NP_001386072.1 voltage-dependent L-type calcium channel subunit beta-4 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/Swiss-Prot

D4A055

UniProtKB/TrEMBL

A0A8L2QRB5, A6JF27

Related

ENSRNOP00000097125.1, ENSRNOT00000107851.2

Conserved Domains (3) summary

cd12043
Location:90 → 157

SH3_CACNB4; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta4

pfam00625
Location:217 → 397

Guanylate_kin; Guanylate kinase

pfam12052
Location:49 → 90

VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

57315900..57578271 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017592000.3 → XP_017447489.1 voltage-dependent L-type calcium channel subunit beta-4 isoform X1

UniProtKB/TrEMBL

A0A8I6ARA9, A0A8L2QRB5

Related

ENSRNOP00000097122.1, ENSRNOT00000095267.2

Conserved Domains (3) summary

cd12043
Location:73 → 140

SH3_CACNB4; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta4

pfam00625
Location:200 → 380

Guanylate_kin; Guanylate kinase

pfam12052
Location:32 → 73

VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal
XM_006234173.5 → XP_006234235.1 voltage-dependent L-type calcium channel subunit beta-4 isoform X2

See identical proteins and their annotated locations for XP_006234235.1

UniProtKB/TrEMBL

A0A8I6A7M3, A0A8L2QRB5

Related

ENSRNOP00000089186.1, ENSRNOT00000104638.2

Conserved Domains (3) summary

cd12043
Location:44 → 111

SH3_CACNB4; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta4

pfam00625
Location:171 → 351

Guanylate_kin; Guanylate kinase

pfam12052
Location:3 → 44

VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal
XM_039105754.2 → XP_038961682.1 voltage-dependent L-type calcium channel subunit beta-4 isoform X5

Conserved Domains (1) summary

pfam00625
Location:65 → 245

Guanylate_kin; Guanylate kinase
XM_063284430.1 → XP_063140500.1 voltage-dependent L-type calcium channel subunit beta-4 isoform X3
XM_063284431.1 → XP_063140501.1 voltage-dependent L-type calcium channel subunit beta-4 isoform X4