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    CATSPERG cation channel sperm associated auxiliary subunit gamma [ Homo sapiens (human) ]

    Gene ID: 57828, updated on 15-Jun-2019

    Summary

    Official Symbol
    CATSPERGprovided by HGNC
    Official Full Name
    cation channel sperm associated auxiliary subunit gammaprovided by HGNC
    Primary source
    HGNC:HGNC:25243
    See related
    Ensembl:ENSG00000099338 MIM:613452
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C19orf15
    Summary
    CATSPERG is a subunit of the CATSPER (see CATSPER1; MIM 606389) sperm calcium channel, which is required for sperm hyperactivated motility and male fertility (Wang et al., 2009 [PubMed 19516020]).[supplied by OMIM, Jul 2010]
    Expression
    Restricted expression toward testis (RPKM 11.5) See more
    Orthologs

    Genomic context

    See CATSPERG in Genome Data Viewer
    Location:
    19q13.2
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (38335563..38370949)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (38826443..38861589)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene chromosome 19 open reading frame 33 Neighboring gene Yip1 interacting factor homolog B, membrane trafficking protein Neighboring gene potassium two pore domain channel subfamily K member 6 Neighboring gene proteasome 26S subunit, non-ATPase 8 Neighboring gene gametogenetin

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Pathways from BioSystems

    • Fertilization, organism-specific biosystem (from REACTOME)
      Fertilization, organism-specific biosystemMammalian fertilization comprises sperm migration through the female reproductive tract, biochemical and morphological changes to sperm, and sperm-egg interaction in the oviduct. Although the broad c...
    • Reproduction, organism-specific biosystem (from REACTOME)
      Reproduction, organism-specific biosystemHuman reproduction mixes the genomes of two individuals creating a new organism. The offspring individuals produced by sexual reproduction differ from their parents and from their siblings. Reproduct...
    • Sperm Motility And Taxes, organism-specific biosystem (from REACTOME)
      Sperm Motility And Taxes, organism-specific biosystemA series of receptor signaling pathways potentially govern chemical communication between sperm and egg, chemotactically guiding incoming sperm towards the oocyte. Though several substances are confi...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ38899, FLJ46353, MGC125664, DKFZp434A1022

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    response to progesterone TAS
    Traceable Author Statement
    more info
     
    sperm-egg recognition TAS
    Traceable Author Statement
    more info
     
    spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    CatSper complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    CatSper complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    motile cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    sperm principal piece IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    cation channel sperm-associated protein subunit gamma
    Names
    catsper channel auxiliary subunit gamma

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001330496.2NP_001317425.1  cation channel sperm-associated protein subunit gamma isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC005625, AC005789, BC060889
      Consensus CDS
      CCDS82346.1
      UniProtKB/TrEMBL
      B8ZZI7
      Related
      ENSP00000387057.1, ENST00000410018.5
    2. NM_021185.5NP_067008.3  cation channel sperm-associated protein subunit gamma isoform 1 precursor

      See identical proteins and their annotated locations for NP_067008.3

      Status: VALIDATED

      Source sequence(s)
      AK128220, AW072458, BC060889, BC109035
      Consensus CDS
      CCDS12514.2
      UniProtKB/Swiss-Prot
      Q6ZRH7
      UniProtKB/TrEMBL
      Q32MQ2
      Related
      ENSP00000386962.3, ENST00000409235.8
      Conserved Domains (1) summary
      pfam15064
      Location:13976
      CATSPERG; Cation channel sperm-associated protein subunit gamma

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

      Range
      38335830..38370943
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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