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    USP28 ubiquitin specific peptidase 28 [ Homo sapiens (human) ]

    Gene ID: 57646, updated on 5-Sep-2021

    Summary

    Official Symbol
    USP28provided by HGNC
    Official Full Name
    ubiquitin specific peptidase 28provided by HGNC
    Primary source
    HGNC:HGNC:12625
    See related
    Ensembl:ENSG00000048028 MIM:610748
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    The protein encoded by this gene is a deubiquitinase involved in the DNA damage pathway and DNA damage-induced apoptosis. Overexpression of this gene is seen in several cancers. [provided by RefSeq, Oct 2016]
    Expression
    Ubiquitous expression in heart (RPKM 11.8), lymph node (RPKM 4.2) and 24 other tissues See more
    Orthologs
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    Genomic context

    See USP28 in Genome Data Viewer
    Location:
    11q23.2
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (113797875..113875572, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (113668597..113746294, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 37 member A13, pseudogene Neighboring gene activating transcription factor 4 pseudogene 4 Neighboring gene interferon stimulated exonuclease gene 20 like 2 pseudogene Neighboring gene RNA, U6 small nuclear 1107, pseudogene Neighboring gene Sharpr-MPRA regulatory region 42 Neighboring gene 5-hydroxytryptamine receptor 3B Neighboring gene 5-hydroxytryptamine receptor 3A

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Clone Names

    • KIAA1515

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables thiol-dependent deubiquitinase IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables thiol-dependent deubiquitinase IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables thiol-dependent deubiquitinase IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables thiol-dependent deubiquitinase TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nuclear body IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    ubiquitin carboxyl-terminal hydrolase 28
    Names
    deubiquitinating enzyme 28
    ubiquitin carboxyl-terminal hydrolase 28 variant 1
    ubiquitin thioesterase 28
    ubiquitin thiolesterase 28
    ubiquitin-specific-processing protease 28
    NP_001287958.1
    NP_001333181.1
    NP_001333182.1
    NP_001333183.1
    NP_001333184.1
    NP_001333186.1
    NP_001333187.1
    NP_001333188.1
    NP_001333189.1
    NP_001333190.1
    NP_001333191.1
    NP_001333192.1
    NP_001333193.1
    NP_001333194.1
    NP_001333196.1
    NP_001333197.1
    NP_001333198.1
    NP_001333199.1
    NP_001333200.1
    NP_001333201.1
    NP_001333202.1
    NP_065937.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_051668.1 RefSeqGene

      Range
      4999..82696
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001301029.2NP_001287958.1  ubiquitin carboxyl-terminal hydrolase 28 isoform b

      See identical proteins and their annotated locations for NP_001287958.1

      Status: REVIEWED

      Source sequence(s)
      AK304770, AP001874, AP003170, BC035986, BF434481, DB061316
      Consensus CDS
      CCDS73394.1
      UniProtKB/TrEMBL
      B4E3L3
      Related
      ENSP00000444991.1, ENST00000545540.5
      Conserved Domains (3) summary
      cd02665
      Location:38523
      Peptidase_C19I; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cl02553
      Location:38142
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam00443
      Location:36273
      UCH; Ubiquitin carboxyl-terminal hydrolase
    2. NM_001346252.4NP_001333181.1  ubiquitin carboxyl-terminal hydrolase 28 isoform c

      Status: REVIEWED

      Source sequence(s)
      AP001874, AP003170, KF459544
    3. NM_001346253.2NP_001333182.1  ubiquitin carboxyl-terminal hydrolase 28 isoform d

      Status: REVIEWED

      Source sequence(s)
      AP001874, AP003170, KF459544
    4. NM_001346254.2NP_001333183.1  ubiquitin carboxyl-terminal hydrolase 28 isoform e

      Status: REVIEWED

      Source sequence(s)
      AP001874, AP003170, KF459544
    5. NM_001346255.2NP_001333184.1  ubiquitin carboxyl-terminal hydrolase 28 isoform f

      Status: REVIEWED

      Source sequence(s)
      AP001874, AP003170, KF459544
    6. NM_001346257.2NP_001333186.1  ubiquitin carboxyl-terminal hydrolase 28 isoform g

      Status: REVIEWED

      Source sequence(s)
      AP001874, AP003170, KF459544
    7. NM_001346258.2NP_001333187.1  ubiquitin carboxyl-terminal hydrolase 28 isoform h

      Status: REVIEWED

      Source sequence(s)
      AP001874, AP003170, KF459544
      UniProtKB/Swiss-Prot
      Q96RU2
    8. NM_001346259.2NP_001333188.1  ubiquitin carboxyl-terminal hydrolase 28 isoform i

      Status: REVIEWED

      Source sequence(s)
      AP001874, AP003170, KF459544
    9. NM_001346260.2NP_001333189.1  ubiquitin carboxyl-terminal hydrolase 28 isoform j

      Status: REVIEWED

      Source sequence(s)
      AP001874, AP003170, KF459544
    10. NM_001346261.2NP_001333190.1  ubiquitin carboxyl-terminal hydrolase 28 isoform k

      Status: REVIEWED

      Source sequence(s)
      AP001874, AP003170, KF459544
    11. NM_001346262.2NP_001333191.1  ubiquitin carboxyl-terminal hydrolase 28 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (12), as well as variant 2, encodes isoform b.
      Source sequence(s)
      AP001874, AP003170, KF459544
      Consensus CDS
      CCDS73394.1
      UniProtKB/TrEMBL
      B4E3L3
    12. NM_001346263.2NP_001333192.1  ubiquitin carboxyl-terminal hydrolase 28 isoform l

      Status: REVIEWED

      Source sequence(s)
      AP001874, AP003170, KF459544
    13. NM_001346264.2NP_001333193.1  ubiquitin carboxyl-terminal hydrolase 28 isoform m

      Status: REVIEWED

      Source sequence(s)
      AP001874, AP003170, KF459544
    14. NM_001346265.2NP_001333194.1  ubiquitin carboxyl-terminal hydrolase 28 isoform n

      Status: REVIEWED

      Source sequence(s)
      AP001874, AP003170, KF459544
    15. NM_001346267.2NP_001333196.1  ubiquitin carboxyl-terminal hydrolase 28 isoform o

      Status: REVIEWED

      Description
      Transcript Variant: This variant (16), as well as variant 17, encodes isoform o.
      Source sequence(s)
      AP001874, AP003170, KF459544
    16. NM_001346268.2NP_001333197.1  ubiquitin carboxyl-terminal hydrolase 28 isoform o

      Status: REVIEWED

      Description
      Transcript Variant: This variant (17), as well as variant 16, encodes isoform o.
      Source sequence(s)
      AP001874, AP003170, KF459544
      Related
      ENSP00000442431.1, ENST00000544967.5
    17. NM_001346269.2NP_001333198.1  ubiquitin carboxyl-terminal hydrolase 28 isoform p

      Status: REVIEWED

      Description
      Transcript Variant: This variant (18), as well as variants 19 and 20, encodes isoform p.
      Source sequence(s)
      AP001874, AP003170, KF459544
    18. NM_001346270.2NP_001333199.1  ubiquitin carboxyl-terminal hydrolase 28 isoform p

      Status: REVIEWED

      Description
      Transcript Variant: This variant (19), as well as variants 18 and 20, encodes isoform p.
      Source sequence(s)
      AP001874, AP003170, KF459544
    19. NM_001346271.2NP_001333200.1  ubiquitin carboxyl-terminal hydrolase 28 isoform p

      Status: REVIEWED

      Description
      Transcript Variant: This variant (20), as well as variants 18 and 19, encodes isoform p.
      Source sequence(s)
      AP001874, AP003170, KF459544
    20. NM_001346272.2NP_001333201.1  ubiquitin carboxyl-terminal hydrolase 28 isoform q

      Status: REVIEWED

      Source sequence(s)
      AP001874, AP003170, KF459544
    21. NM_001346273.2NP_001333202.1  ubiquitin carboxyl-terminal hydrolase 28 isoform r

      Status: REVIEWED

      Source sequence(s)
      AP001874, BC065928, DB061316
      Consensus CDS
      CCDS86248.1
      UniProtKB/Swiss-Prot
      Q96RU2
      Related
      ENSP00000445743.1, ENST00000537706.5
      Conserved Domains (3) summary
      cd02665
      Location:163397
      Peptidase_C19I; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cd14355
      Location:2364
      UBA_UBP28; UBA domain found in ubiquitin carboxyl-terminal hydrolase 28 (UBP28) and similar proteins
      cl02553
      Location:163267
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    22. NM_020886.4NP_065937.1  ubiquitin carboxyl-terminal hydrolase 28 isoform a

      See identical proteins and their annotated locations for NP_065937.1

      Status: REVIEWED

      Source sequence(s)
      AF266283, AP001874, AP003170, BC035986, BF434481, DB061316
      Consensus CDS
      CCDS31680.1
      UniProtKB/Swiss-Prot
      Q96RU2
      Related
      ENSP00000003302.4, ENST00000003302.8
      Conserved Domains (4) summary
      cd02665
      Location:163648
      Peptidase_C19I; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cd14355
      Location:2364
      UBA_UBP28; UBA domain found in ubiquitin carboxyl-terminal hydrolase 28 (UBP28) and similar proteins
      cl02553
      Location:163267
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam00443
      Location:161398
      UCH; Ubiquitin carboxyl-terminal hydrolase

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

      Range
      113797875..113875572 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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