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    LRRN1 leucine rich repeat neuronal 1 [ Homo sapiens (human) ]

    Gene ID: 57633, updated on 17-Jun-2019

    Summary

    Official Symbol
    LRRN1provided by HGNC
    Official Full Name
    leucine rich repeat neuronal 1provided by HGNC
    Primary source
    HGNC:HGNC:20980
    See related
    Ensembl:ENSG00000175928
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NLRR-1; FIGLER3
    Expression
    Biased expression in brain (RPKM 12.5), testis (RPKM 4.5) and 8 other tissues See more
    Orthologs

    Genomic context

    See LRRN1 in Genome Data Viewer
    Location:
    3p26.2
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (3799431..3849834)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (3841121..3889708)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene interleukin 5 receptor subunit alpha Neighboring gene tRNA nucleotidyl transferase 1 Neighboring gene cereblon Neighboring gene uncharacterized LOC100130207 Neighboring gene uncharacterized LOC107986007 Neighboring gene uncharacterized LOC102723512 Neighboring gene polyribonucleotide nucleotidyltransferase 1 pseudogene 1 Neighboring gene sulfatase modifying factor 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA1497

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    positive regulation of synapse assembly IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    leucine-rich repeat neuronal protein 1
    Names
    fibronectin type III, immunoglobulin and leucine rich repeat domains 3
    neuronal leucine-rich repeat protein 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001324188.2NP_001311117.1  leucine-rich repeat neuronal protein 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC023484, BC012463
      Consensus CDS
      CCDS33685.1
      UniProtKB/Swiss-Prot
      Q6UXK5
      Conserved Domains (8) summary
      smart00082
      Location:371419
      LRRCT; Leucine rich repeat C-terminal domain
      cd00116
      Location:13273
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      pfam07679
      Location:429516
      I-set; Immunoglobulin I-set domain
      sd00031
      Location:339362
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:97120
      LRR_RI; leucine-rich repeat [structural motif]
      pfam00041
      Location:531600
      fn3; Fibronectin type III domain
      pfam13855
      Location:119179
      LRR_8; Leucine rich repeat
      cl11960
      Location:431516
      Ig; Immunoglobulin domain
    2. NM_001324189.2NP_001311118.1  leucine-rich repeat neuronal protein 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC023484, BC012463
      Consensus CDS
      CCDS33685.1
      UniProtKB/Swiss-Prot
      Q6UXK5
      Conserved Domains (8) summary
      smart00082
      Location:371419
      LRRCT; Leucine rich repeat C-terminal domain
      cd00116
      Location:13273
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      pfam07679
      Location:429516
      I-set; Immunoglobulin I-set domain
      sd00031
      Location:339362
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:97120
      LRR_RI; leucine-rich repeat [structural motif]
      pfam00041
      Location:531600
      fn3; Fibronectin type III domain
      pfam13855
      Location:119179
      LRR_8; Leucine rich repeat
      cl11960
      Location:431516
      Ig; Immunoglobulin domain
    3. NM_020873.7NP_065924.3  leucine-rich repeat neuronal protein 1 precursor

      See identical proteins and their annotated locations for NP_065924.3

      Status: VALIDATED

      Description
      Transcript Variant: Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC023484, AK291717, AU154359, BC012463, BC034947, BU685265, CX867219, DA736067
      Consensus CDS
      CCDS33685.1
      UniProtKB/Swiss-Prot
      Q6UXK5
      UniProtKB/TrEMBL
      A8K6Q2
      Related
      ENSP00000314901.3, ENST00000319331.3
      Conserved Domains (8) summary
      smart00082
      Location:371419
      LRRCT; Leucine rich repeat C-terminal domain
      cd00116
      Location:13273
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      pfam07679
      Location:429516
      I-set; Immunoglobulin I-set domain
      sd00031
      Location:339362
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:97120
      LRR_RI; leucine-rich repeat [structural motif]
      pfam00041
      Location:531600
      fn3; Fibronectin type III domain
      pfam13855
      Location:119179
      LRR_8; Leucine rich repeat
      cl11960
      Location:431516
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

      Range
      3799431..3849834
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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