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    ZNF687 zinc finger protein 687 [ Homo sapiens (human) ]

    Gene ID: 57592, updated on 17-Jun-2019

    Summary

    Official Symbol
    ZNF687provided by HGNC
    Official Full Name
    zinc finger protein 687provided by HGNC
    Primary source
    HGNC:HGNC:29277
    See related
    Ensembl:ENSG00000143373 MIM:610568
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PDB6
    Summary
    This gene encodes C2H2 zinc finger protein. The encoded protein may play a role in bone differentiation and development. Mutations in this gene are the cause of Paget disease of bone-6. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]
    Expression
    Ubiquitous expression in bone marrow (RPKM 9.1), testis (RPKM 7.2) and 25 other tissues See more
    Orthologs

    Genomic context

    See ZNF687 in Genome Data Viewer
    Location:
    1q21.3
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (151281522..151292176)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (151254094..151264381)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol-4-phosphate 5-kinase type 1 alpha Neighboring gene Sharpr-MPRA regulatory region 10214 Neighboring gene proteasome 26S subunit, non-ATPase 4 Neighboring gene ZNF687 antisense RNA 1 Neighboring gene phosphatidylinositol 4-kinase beta Neighboring gene RNA, 7SL, cytoplasmic 444, pseudogene Neighboring gene Sharpr-MPRA regulatory region 1421

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat 47-59 peptide downregulates gene expression of zinc finger protein 687 (ZNF687) in U-937 macrophages PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA1441, DKFZp781I1719

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    DNA-binding transcription factor activity, RNA polymerase II-specific ISA
    Inferred from Sequence Alignment
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_051575.1 RefSeqGene

      Range
      5001..15351
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001304763.2NP_001291692.1  zinc finger protein 687

      See identical proteins and their annotated locations for NP_001291692.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest transcript. All three variants encode the same protein.
      Source sequence(s)
      AB037862, AL391069, CR749307
      Consensus CDS
      CCDS992.1
      UniProtKB/Swiss-Prot
      Q8N1G0
      Related
      ENSP00000319829.5, ENST00000324048.9
      Conserved Domains (3) summary
      sd00017
      Location:965985
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam15909
      Location:795877
      zf-C2H2_8; C2H2-type zinc ribbon
      pfam16622
      Location:11311159
      zf-C2H2_11; zinc-finger C2H2-type
    2. NM_001304764.2NP_001291693.1  zinc finger protein 687

      See identical proteins and their annotated locations for NP_001291693.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
      Source sequence(s)
      AL391069, BC032463, CR749307
      Consensus CDS
      CCDS992.1
      UniProtKB/Swiss-Prot
      Q8N1G0
      Conserved Domains (3) summary
      sd00017
      Location:965985
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam15909
      Location:795877
      zf-C2H2_8; C2H2-type zinc ribbon
      pfam16622
      Location:11311159
      zf-C2H2_11; zinc-finger C2H2-type
    3. NM_020832.3NP_065883.1  zinc finger protein 687

      See identical proteins and their annotated locations for NP_065883.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
      Source sequence(s)
      AB037862, AL391069, BC032463, CR749307
      Consensus CDS
      CCDS992.1
      UniProtKB/Swiss-Prot
      Q8N1G0
      Related
      ENSP00000336620.5, ENST00000336715.11
      Conserved Domains (3) summary
      sd00017
      Location:965985
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam15909
      Location:795877
      zf-C2H2_8; C2H2-type zinc ribbon
      pfam16622
      Location:11311159
      zf-C2H2_11; zinc-finger C2H2-type

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

      Range
      151281522..151292176
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005245366.4XP_005245423.1  zinc finger protein 687 isoform X1

      Conserved Domains (3) summary
      sd00017
      Location:974994
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam15909
      Location:804886
      zf-C2H2_8; C2H2-type zinc ribbon
      pfam16622
      Location:11401168
      zf-C2H2_11; zinc-finger C2H2-type
    2. XM_011509813.2XP_011508115.1  zinc finger protein 687 isoform X2

      See identical proteins and their annotated locations for XP_011508115.1

      UniProtKB/Swiss-Prot
      Q8N1G0
      Conserved Domains (3) summary
      sd00017
      Location:965985
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam15909
      Location:795877
      zf-C2H2_8; C2H2-type zinc ribbon
      pfam16622
      Location:11311159
      zf-C2H2_11; zinc-finger C2H2-type
    3. XM_011509812.2XP_011508114.1  zinc finger protein 687 isoform X2

      See identical proteins and their annotated locations for XP_011508114.1

      UniProtKB/Swiss-Prot
      Q8N1G0
      Conserved Domains (3) summary
      sd00017
      Location:965985
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam15909
      Location:795877
      zf-C2H2_8; C2H2-type zinc ribbon
      pfam16622
      Location:11311159
      zf-C2H2_11; zinc-finger C2H2-type
    4. XM_011509811.2XP_011508113.1  zinc finger protein 687 isoform X3

      Conserved Domains (2) summary
      sd00017
      Location:906926
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam16622
      Location:10721100
      zf-C2H2_11; zinc-finger C2H2-type
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