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    ARHGAP21 Rho GTPase activating protein 21 [ Homo sapiens (human) ]

    Gene ID: 57584, updated on 15-Jun-2019

    Summary

    Official Symbol
    ARHGAP21provided by HGNC
    Official Full Name
    Rho GTPase activating protein 21provided by HGNC
    Primary source
    HGNC:HGNC:23725
    See related
    Ensembl:ENSG00000107863 MIM:609870
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ARHGAP10
    Summary
    ARHGAP21 functions preferentially as a GTPase-activating protein (GAP) for CDC42 (MIM 116952) and regulates the ARP2/3 complex (MIM 604221) and F-actin dynamics at the Golgi through control of CDC42 activity (Dubois et al., 2005 [PubMed 15793564]).[supplied by OMIM, Mar 2008]
    Expression
    Ubiquitous expression in brain (RPKM 26.0), fat (RPKM 12.0) and 25 other tissues See more
    Orthologs

    Genomic context

    See ARHGAP21 in Genome Data Viewer
    Location:
    10p12.1; 10p12.3
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 10 NC_000010.11 (24583609..24725421, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (24872538..25012597, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene KIAA1217 Neighboring gene microRNA 603 Neighboring gene uncharacterized LOC105376455 Neighboring gene RNA, 5S ribosomal pseudogene 305 Neighboring gene coenzyme Q10B pseudogene 1 Neighboring gene uncharacterized LOC105376456 Neighboring gene phosphoribosyl transferase domain containing 1 Neighboring gene RN7SK pseudogene 241

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Rho GTPase cycle, organism-specific biosystem (from REACTOME)
      Rho GTPase cycle, organism-specific biosystemThe cycling of Rho GTPases is tightly controlled by three classes of protein. These are (1) guanine nucleotide dissociation inhibitors or GDIs, which maintain Rho proteins in an inactive state in the...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by Rho GTPases, organism-specific biosystem (from REACTOME)
      Signaling by Rho GTPases, organism-specific biosystemThe Rho family of small guanine nucleotide binding proteins is one of five generally recognized branches of the Ras superfamily. Like most Ras superfamily members, typical Rho proteins function as bi...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ33323, FLJ90108, DKFZp761L0424

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    Golgi organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    establishment of Golgi localization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    maintenance of Golgi location IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    organelle transport along microtubule IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of small GTPase mediated signal transduction TAS
    Traceable Author Statement
    more info
     
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
     
    actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
     
    cell junction IDA
    Inferred from Direct Assay
    more info
     
    cytoplasmic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    rho GTPase-activating protein 21
    Names
    Rho-GTPase activating protein 10
    rho GTPase-activating protein 10
    rho-type GTPase-activating protein 21

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001367447.1NP_001354376.1  rho GTPase-activating protein 21 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4), as well as variants 5 and 6, encodes isoform b.
      Source sequence(s)
      AL355979, AL392104
    2. NM_001367448.1NP_001354377.1  rho GTPase-activating protein 21 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2), as well as variants 1 and 3, encodes isoform a.
      Source sequence(s)
      AL355979, AL392104
      Conserved Domains (3) summary
      cd00992
      Location:48155
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd04395
      Location:11441339
      RhoGAP_ARHGAP21; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction ...
      cd01253
      Location:9331042
      PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
    3. NM_001367449.1NP_001354378.1  rho GTPase-activating protein 21 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7), as well as variant 8, encodes isoform c.
      Source sequence(s)
      AL355979, AL392104
    4. NM_001367450.1NP_001354379.1  rho GTPase-activating protein 21 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8), as well as variant 7, encodes isoform c.
      Source sequence(s)
      AL355979, AL392104
    5. NM_001367451.1NP_001354380.1  rho GTPase-activating protein 21 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5), as well as variants 4 and 6, encodes isoform b.
      Source sequence(s)
      AL355979, AL392104
    6. NM_001367452.1NP_001354381.1  rho GTPase-activating protein 21 isoform d

      Status: VALIDATED

      Source sequence(s)
      AL355979, AL392104
    7. NM_001367453.1NP_001354382.1  rho GTPase-activating protein 21 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6), as well as variants 4 and 5, encodes isoform b.
      Source sequence(s)
      AL355979, AL392104
    8. NM_001367454.1NP_001354383.1  rho GTPase-activating protein 21 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3), as well as variants 1 and 2, encodes isoform a.
      Source sequence(s)
      AL355979, AL392104
      Conserved Domains (3) summary
      cd00992
      Location:48155
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd04395
      Location:11441339
      RhoGAP_ARHGAP21; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction ...
      cd01253
      Location:9331042
      PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
    9. NM_001367455.1NP_001354384.1  rho GTPase-activating protein 21 isoform e

      Status: VALIDATED

      Source sequence(s)
      AL392104
    10. NM_020824.4NP_065875.3  rho GTPase-activating protein 21 isoform a

      See identical proteins and their annotated locations for NP_065875.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1, 2, and 3 all encode the same isoform (a).
      Source sequence(s)
      AB037845, AF480466, AL355979, AV709499, BI491305, BQ026288
      Consensus CDS
      CCDS7144.2
      UniProtKB/Swiss-Prot
      Q5T5U3
      Related
      ENSP00000379709.2, ENST00000396432.7
      Conserved Domains (3) summary
      cd00992
      Location:48155
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd04395
      Location:11441339
      RhoGAP_ARHGAP21; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction ...
      cd01253
      Location:9331042
      PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain

    RNA

    1. NR_160021.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL355979, AL392104
    2. NR_160022.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL355979, AL392104
    3. NR_160023.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL355979, AL392104
    4. NR_160024.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL392104
    5. NR_160025.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL392104

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

      Range
      24583610..24725421 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011519605.2XP_011517907.1  rho GTPase-activating protein 21 isoform X2

      Conserved Domains (4) summary
      cd00992
      Location:48155
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd04395
      Location:11681363
      RhoGAP_ARHGAP21; RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the ...
      cd01253
      Location:9571066
      PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
      pfam00169
      Location:9581063
      PH; PH domain
    2. XM_011519607.2XP_011517909.1  rho GTPase-activating protein 21 isoform X7

      Conserved Domains (4) summary
      cd00992
      Location:48155
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd04395
      Location:11781373
      RhoGAP_ARHGAP21; RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the ...
      cd01253
      Location:9671076
      PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
      pfam00169
      Location:9681073
      PH; PH domain
    3. XM_011519602.2XP_011517904.1  rho GTPase-activating protein 21 isoform X1

      See identical proteins and their annotated locations for XP_011517904.1

      Conserved Domains (4) summary
      cd00992
      Location:48155
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd04395
      Location:11781373
      RhoGAP_ARHGAP21; RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the ...
      cd01253
      Location:9671076
      PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
      pfam00169
      Location:9681073
      PH; PH domain
    4. XM_011519604.2XP_011517906.1  rho GTPase-activating protein 21 isoform X1

      See identical proteins and their annotated locations for XP_011517906.1

      Conserved Domains (4) summary
      cd00992
      Location:48155
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd04395
      Location:11781373
      RhoGAP_ARHGAP21; RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the ...
      cd01253
      Location:9671076
      PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
      pfam00169
      Location:9681073
      PH; PH domain
    5. XM_017016459.2XP_016871948.1  rho GTPase-activating protein 21 isoform X3

      Conserved Domains (3) summary
      cd00992
      Location:48155
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd04395
      Location:11441339
      RhoGAP_ARHGAP21; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction ...
      cd01253
      Location:9331042
      PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
    6. XM_011519603.3XP_011517905.1  rho GTPase-activating protein 21 isoform X1

      See identical proteins and their annotated locations for XP_011517905.1

      Conserved Domains (4) summary
      cd00992
      Location:48155
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd04395
      Location:11781373
      RhoGAP_ARHGAP21; RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the ...
      cd01253
      Location:9671076
      PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
      pfam00169
      Location:9681073
      PH; PH domain
    7. XM_024448088.1XP_024303856.1  rho GTPase-activating protein 21 isoform X6

      Conserved Domains (3) summary
      cd00992
      Location:3487
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd04395
      Location:11001295
      RhoGAP_ARHGAP21; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction ...
      cd01253
      Location:889998
      PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
    8. XM_011519606.2XP_011517908.1  rho GTPase-activating protein 21 isoform X5

      Conserved Domains (4) summary
      cd00992
      Location:3487
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd04395
      Location:11101305
      RhoGAP_ARHGAP21; RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the ...
      cd01253
      Location:8991008
      PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
      pfam00169
      Location:9001005
      PH; PH domain

    RNA

    1. XR_242701.5 RNA Sequence

    2. XR_930513.3 RNA Sequence

    3. XR_001747163.2 RNA Sequence

    4. XR_001747160.2 RNA Sequence

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