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    STAMBPL1 STAM binding protein like 1 [ Homo sapiens (human) ]

    Gene ID: 57559, updated on 17-Jun-2019

    Summary

    Official Symbol
    STAMBPL1provided by HGNC
    Official Full Name
    STAM binding protein like 1provided by HGNC
    Primary source
    HGNC:HGNC:24105
    See related
    Ensembl:ENSG00000138134 MIM:612352
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AMSH-FP; AMSH-LP; ALMalpha; bA399O19.2
    Expression
    Broad expression in adrenal (RPKM 7.5), testis (RPKM 6.2) and 22 other tissues See more
    Orthologs

    Genomic context

    See STAMBPL1 in Genome Data Viewer
    Location:
    10q23.31
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (88879368..88923502)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (90639597..90735343)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene lipase family member M Neighboring gene ankyrin repeat domain 22 Neighboring gene pentatricopeptide repeat domain 2 pseudogene 2 Neighboring gene uncharacterized LOC105379869 Neighboring gene ACTA2 antisense RNA 1 Neighboring gene actin alpha 2, smooth muscle

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Deubiquitination, organism-specific biosystem (from REACTOME)
      Deubiquitination, organism-specific biosystemUbiquitination, the modification of proteins by the covalent attachment of ubiquitin (Ub), is a key regulatory mechanism for many many cellular processes, including protein degradation by the 26S pro...
    • Metabolism of proteins, organism-specific biosystem (from REACTOME)
      Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
    • Metalloprotease DUBs, organism-specific biosystem (from REACTOME)
      Metalloprotease DUBs, organism-specific biosystemThe JAB1/MPN +/MOV34 (JAMM) domain metalloproteases cleave the isopeptide bond at or near the the attachment point of polyubiquitin and substrate. PSMD14 (RPN11), STAMBP (AMSH), STAMBPL1 (AMSH-LP), a...
    • Post-translational protein modification, organism-specific biosystem (from REACTOME)
      Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...
    • TGF-beta Signaling Pathway, organism-specific biosystem (from WikiPathways)
      TGF-beta Signaling Pathway, organism-specific biosystemThe signal transduction mechanisms underlying the pathophysiological activities of transforming growth factor-? (TGF-?) have been extensively studied since its discovery nearly 30 years ago. TGF-? li...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ31524, KIAA1373

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    Lys63-specific deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Lys63-specific deubiquitinase activity TAS
    Traceable Author Statement
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    thiol-dependent ubiquitin-specific protease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    protein K63-linked deubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein deubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein deubiquitination TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    cytosol TAS
    Traceable Author Statement
    more info
     
    endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    membrane HDA PubMed 
    membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    AMSH-like protease
    Names
    associated molecule with the SH3 domain of STAM (AMSH) - Family Protein
    associated molecule with the SH3 domain of STAM (AMSH) like protein
    NP_065850.1
    XP_006717991.1
    XP_006717993.1
    XP_011538285.1
    XP_011538287.1
    XP_016871942.1
    XP_016871944.1
    XP_016871945.1
    XP_016871946.1
    XP_016871947.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020799.4NP_065850.1  AMSH-like protease

      See identical proteins and their annotated locations for NP_065850.1

      Status: VALIDATED

      Source sequence(s)
      AK056086, AW006657, CD244526
      Consensus CDS
      CCDS7391.1
      UniProtKB/Swiss-Prot
      Q96FJ0
      Related
      ENSP00000360994.3, ENST00000371926.8
      Conserved Domains (3) summary
      cd08066
      Location:266436
      MPN_AMSH_like; Mov34/MPN/PAD-1 family
      pfam08969
      Location:28129
      USP8_dimer; USP8 dimerization domain
      cl20817
      Location:120198
      GBP_C; Guanylate-binding protein, C-terminal domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

      Range
      88879368..88923502
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006717928.2XP_006717991.1  AMSH-like protease isoform X1

      See identical proteins and their annotated locations for XP_006717991.1

      UniProtKB/Swiss-Prot
      Q96FJ0
      Conserved Domains (3) summary
      cd08066
      Location:266436
      MPN_AMSH_like; Mov34/MPN/PAD-1 family
      pfam08969
      Location:28129
      USP8_dimer; USP8 dimerization domain
      cl20817
      Location:120198
      GBP_C; Guanylate-binding protein, C-terminal domain
    2. XM_006717930.3XP_006717993.1  AMSH-like protease isoform X1

      See identical proteins and their annotated locations for XP_006717993.1

      UniProtKB/Swiss-Prot
      Q96FJ0
      Related
      ENSP00000360995.3, ENST00000371927.7
      Conserved Domains (3) summary
      cd08066
      Location:266436
      MPN_AMSH_like; Mov34/MPN/PAD-1 family
      pfam08969
      Location:28129
      USP8_dimer; USP8 dimerization domain
      cl20817
      Location:120198
      GBP_C; Guanylate-binding protein, C-terminal domain
    3. XM_017016455.1XP_016871944.1  AMSH-like protease isoform X1

      UniProtKB/Swiss-Prot
      Q96FJ0
      Conserved Domains (3) summary
      cd08066
      Location:266436
      MPN_AMSH_like; Mov34/MPN/PAD-1 family
      pfam08969
      Location:28129
      USP8_dimer; USP8 dimerization domain
      cl20817
      Location:120198
      GBP_C; Guanylate-binding protein, C-terminal domain
    4. XM_011539983.1XP_011538285.1  AMSH-like protease isoform X1

      See identical proteins and their annotated locations for XP_011538285.1

      UniProtKB/Swiss-Prot
      Q96FJ0
      Conserved Domains (3) summary
      cd08066
      Location:266436
      MPN_AMSH_like; Mov34/MPN/PAD-1 family
      pfam08969
      Location:28129
      USP8_dimer; USP8 dimerization domain
      cl20817
      Location:120198
      GBP_C; Guanylate-binding protein, C-terminal domain
    5. XM_017016453.1XP_016871942.1  AMSH-like protease isoform X1

      UniProtKB/Swiss-Prot
      Q96FJ0
      Conserved Domains (3) summary
      cd08066
      Location:266436
      MPN_AMSH_like; Mov34/MPN/PAD-1 family
      pfam08969
      Location:28129
      USP8_dimer; USP8 dimerization domain
      cl20817
      Location:120198
      GBP_C; Guanylate-binding protein, C-terminal domain
    6. XM_017016456.1XP_016871945.1  AMSH-like protease isoform X1

      UniProtKB/Swiss-Prot
      Q96FJ0
      Conserved Domains (3) summary
      cd08066
      Location:266436
      MPN_AMSH_like; Mov34/MPN/PAD-1 family
      pfam08969
      Location:28129
      USP8_dimer; USP8 dimerization domain
      cl20817
      Location:120198
      GBP_C; Guanylate-binding protein, C-terminal domain
    7. XM_017016457.2XP_016871946.1  AMSH-like protease isoform X2

    8. XM_011539985.2XP_011538287.1  AMSH-like protease isoform X1

      See identical proteins and their annotated locations for XP_011538287.1

      UniProtKB/Swiss-Prot
      Q96FJ0
      Conserved Domains (3) summary
      cd08066
      Location:266436
      MPN_AMSH_like; Mov34/MPN/PAD-1 family
      pfam08969
      Location:28129
      USP8_dimer; USP8 dimerization domain
      cl20817
      Location:120198
      GBP_C; Guanylate-binding protein, C-terminal domain
    9. XM_017016458.1XP_016871947.1  AMSH-like protease isoform X3

      Related
      ENSP00000360990.1, ENST00000371922.1
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