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    ZNF398 zinc finger protein 398 [ Homo sapiens (human) ]

    Gene ID: 57541, updated on 11-Jun-2021

    Summary

    Official Symbol
    ZNF398provided by HGNC
    Official Full Name
    zinc finger protein 398provided by HGNC
    Primary source
    HGNC:HGNC:18373
    See related
    Ensembl:ENSG00000197024 MIM:618593
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    P51; P71; ZER6
    Summary
    This gene encodes a member of the Kruppel family of C2H2-type zinc-finger transcription factor proteins. The encoded protein acts as a transcriptional activator. Two transcript variants encoding distinct isoforms have been identified for this gene. Other transcript variants have been described, but their full length sequence has not been determined. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in testis (RPKM 4.5), esophagus (RPKM 2.9) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See ZNF398 in Genome Data Viewer
    Location:
    7q36.1
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (149126408..149183042)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (148823500..148880134)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene zinc finger protein 786 Neighboring gene zinc finger protein 425 Neighboring gene RNA, 7SL, cytoplasmic 521, pseudogene Neighboring gene uncharacterized LOC107986856 Neighboring gene centrosomal protein 83kDa pseudogene Neighboring gene zinc finger protein 282 Neighboring gene Sharpr-MPRA regulatory region 80 Neighboring gene zinc finger protein 212

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA1339

    General protein information

    Preferred Names
    zinc finger protein 398
    Names
    zinc finger DNA binding protein ZER6
    zinc finger DNA binding protein p52/p71
    zinc finger-estrogen receptor interaction, clone 6

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020781.4NP_065832.1  zinc finger protein 398 isoform b

      See identical proteins and their annotated locations for NP_065832.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2), also known as p52-ZER6, contains an additional segment in the coding region compared to variant 1. The resulting isoform (b) has a shorter N-terminal, compared to isoform a. Transcription of transcript variant 2 is repressed by estrogen receptor alpha.
      Source sequence(s)
      AC004890, AC073422, AY049743
      Consensus CDS
      CCDS47739.1
      UniProtKB/Swiss-Prot
      Q8TD17
      UniProtKB/TrEMBL
      A0A090N8F2
      Related
      ENSP00000389972.2, ENST00000426851.6
      Conserved Domains (4) summary
      COG5048
      Location:173417
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:314334
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:368390
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:382407
      zf-H2C2_2; Zinc-finger double domain
    2. NM_170686.3NP_733787.1  zinc finger protein 398 isoform a

      See identical proteins and their annotated locations for NP_733787.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1), also known as p71-ZER6, represents the shorter transcript, and encodes the longer isoform a.
      Source sequence(s)
      AC004890, AK026380, AY049744
      Consensus CDS
      CCDS5894.1
      UniProtKB/Swiss-Prot
      Q8TD17
      UniProtKB/TrEMBL
      A0A090N7S8
      Related
      ENSP00000420418.1, ENST00000475153.6
      Conserved Domains (4) summary
      smart00349
      Location:143201
      KRAB; krueppel associated box
      COG5048
      Location:344588
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:485505
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl25732
      Location:48121
      SMC_N; RecF/RecN/SMC N terminal domain

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

      Range
      149126408..149183042
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011516441.2XP_011514743.1  zinc finger protein 398 isoform X3

      See identical proteins and their annotated locations for XP_011514743.1

      UniProtKB/Swiss-Prot
      Q8TD17
      UniProtKB/TrEMBL
      A0A090N8F2
      Related
      ENSP00000418564.1, ENST00000483892.5
      Conserved Domains (4) summary
      COG5048
      Location:173417
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:314334
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:368390
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:382407
      zf-H2C2_2; Zinc-finger double domain
    2. XM_011516440.2XP_011514742.1  zinc finger protein 398 isoform X2

      Conserved Domains (7) summary
      cd07765
      Location:136175
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
      smart00349
      Location:136194
      KRAB; krueppel associated box
      COG5048
      Location:337581
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:478498
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:532554
      zf-C2H2; Zinc finger, C2H2 type
      pfam12417
      Location:50105
      DUF3669; Zinc finger protein
      pfam13465
      Location:546571
      zf-H2C2_2; Zinc-finger double domain
    3. XM_011516439.2XP_011514741.1  zinc finger protein 398 isoform X1

      See identical proteins and their annotated locations for XP_011514741.1

      UniProtKB/TrEMBL
      B4DXA9
      Conserved Domains (7) summary
      cd07765
      Location:148187
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
      smart00349
      Location:148206
      KRAB; krueppel associated box
      COG5048
      Location:349593
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:490510
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:544566
      zf-C2H2; Zinc finger, C2H2 type
      pfam12417
      Location:62117
      DUF3669; Zinc finger protein
      pfam13465
      Location:558583
      zf-H2C2_2; Zinc-finger double domain
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