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    NDRG2 NDRG family member 2 [ Homo sapiens (human) ]

    Gene ID: 57447, updated on 27-Nov-2024

    Summary

    Official Symbol
    NDRG2provided by HGNC
    Official Full Name
    NDRG family member 2provided by HGNC
    Primary source
    HGNC:HGNC:14460
    See related
    Ensembl:ENSG00000165795 MIM:605272; AllianceGenome:HGNC:14460
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SYLD
    Summary
    This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein that may play a role in neurite outgrowth. This gene may be involved in glioblastoma carcinogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2017]
    Expression
    Broad expression in salivary gland (RPKM 217.5), brain (RPKM 177.5) and 19 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See NDRG2 in Genome Data Viewer
    Location:
    14q11.2
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (21016763..21070872, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (15214166..15268302, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (21484922..21539031, complement)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101929718 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr14:21464288-21465487 Neighboring gene methyltransferase like 17 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr14:21467511-21468710 Neighboring gene solute carrier family 39 member 2 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr14:21487674-21488873 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5576 Neighboring gene microRNA 6717 Neighboring gene tubulin polymerization promoting protein family member 2 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:21507297-21507461 Neighboring gene ribonuclease A family member 13 (inactive) Neighboring gene uncharacterized LOC105370398 Neighboring gene ribonuclease A family member 7 Neighboring gene ribonuclease A family member 8 Neighboring gene Rho guanine nucleotide exchange factor 40 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5577 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5578 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5579 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:21539187-21539808 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr14:21550650-21551849 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr14:21552808-21554007 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:21554944-21555488 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:21555489-21556031 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:21558438-21559283 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:21559284-21560128 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5581 Neighboring gene Sharpr-MPRA regulatory region 8150 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:21565235-21565736 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:21566496-21566996 Neighboring gene zinc finger protein 219 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:21571456-21572200 Neighboring gene transmembrane protein 253 Neighboring gene cytoskeleton associated protein 2 pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ25522, KIAA1248, DKFZp781G1938

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in extracellular exosome HDA PubMed 
    located_in growth cone IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    protein NDRG2
    Names
    N-myc downstream regulator 2
    N-myc downstream-regulated gene 2 protein
    NDR1-related protein NDR2
    cytoplasmic protein Ndr1
    syld709613 protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001282211.2NP_001269140.1  protein NDRG2 isoform c

      See identical proteins and their annotated locations for NP_001269140.1

      Status: REVIEWED

      Source sequence(s)
      AK293514, BF341160, BX248031
      Consensus CDS
      CCDS61386.1
      UniProtKB/TrEMBL
      Q8TDR6
      Related
      ENSP00000385889.3, ENST00000403829.7
      Conserved Domains (2) summary
      COG0596
      Location:115309
      MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
      pfam03096
      Location:36314
      Ndr; Ndr family
    2. NM_001282212.2NP_001269141.1  protein NDRG2 isoform d

      See identical proteins and their annotated locations for NP_001269141.1

      Status: REVIEWED

      Source sequence(s)
      AL161668, BF341160, BX247987, BX248031, DA065447
      Consensus CDS
      CCDS73613.1
      UniProtKB/TrEMBL
      Q8TDR6
      Related
      ENSP00000380943.2, ENST00000397844.6
      Conserved Domains (2) summary
      COG0596
      Location:105283
      MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
      pfam03096
      Location:26288
      Ndr; Ndr family
    3. NM_001282213.2NP_001269142.1  protein NDRG2 isoform b

      See identical proteins and their annotated locations for NP_001269142.1

      Status: REVIEWED

      Source sequence(s)
      AL161668
      Consensus CDS
      CCDS9564.1
      UniProtKB/TrEMBL
      Q8TDR6
      Related
      ENSP00000452306.1, ENST00000553503.5
      Conserved Domains (1) summary
      pfam03096
      Location:26304
      Ndr; Ndr family
    4. NM_001282214.2NP_001269143.1  protein NDRG2 isoform b

      See identical proteins and their annotated locations for NP_001269143.1

      Status: REVIEWED

      Source sequence(s)
      AL161668
      Consensus CDS
      CCDS9564.1
      UniProtKB/TrEMBL
      Q8TDR6
      Related
      ENSP00000452038.1, ENST00000555158.5
      Conserved Domains (1) summary
      pfam03096
      Location:26304
      Ndr; Ndr family
    5. NM_001282215.2NP_001269144.1  protein NDRG2 isoform e

      See identical proteins and their annotated locations for NP_001269144.1

      Status: REVIEWED

      Source sequence(s)
      AF304051, AL161668, BC011240, BF341160, BX248031
      Consensus CDS
      CCDS61384.1
      UniProtKB/TrEMBL
      Q8TDR6
      Related
      ENSP00000380945.2, ENST00000397847.6
      Conserved Domains (2) summary
      COG0596
      Location:119302
      MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
      pfam03096
      Location:40307
      Ndr; Ndr family
    6. NM_001282216.2NP_001269145.1  protein NDRG2 isoform f

      See identical proteins and their annotated locations for NP_001269145.1

      Status: REVIEWED

      Source sequence(s)
      AL161668
      UniProtKB/TrEMBL
      G3V578
      Related
      ENSP00000452216.1, ENST00000554104.5
      Conserved Domains (2) summary
      COG0596
      Location:59253
      MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
      pfam03096
      Location:21258
      Ndr; Ndr family
    7. NM_001320329.2NP_001307258.1  protein NDRG2 isoform a

      Status: REVIEWED

      Source sequence(s)
      AL161668
      Consensus CDS
      CCDS9565.1
      UniProtKB/Swiss-Prot
      B3KUE3, B4DE86, B7WP11, B7WPD5, D3DS07, D3DS10, Q567T1, Q68DW2, Q86U08, Q86U46, Q96FD3, Q96FT0, Q96JU0, Q96PN0, Q9BQH5, Q9ULH2, Q9UN36
      UniProtKB/TrEMBL
      Q8TDR6
      Related
      ENSP00000451712.1, ENST00000556147.6
      Conserved Domains (1) summary
      pfam03096
      Location:40318
      Ndr; Ndr family
    8. NM_001354558.2NP_001341487.1  protein NDRG2 isoform g

      Status: REVIEWED

      Source sequence(s)
      AL161668
      UniProtKB/TrEMBL
      Q8TDR6
      Conserved Domains (1) summary
      pfam03096
      Location:40336
      Ndr; Ndr family
    9. NM_001354559.2NP_001341488.1  protein NDRG2 isoform a

      Status: REVIEWED

      Source sequence(s)
      AL161668
      Consensus CDS
      CCDS9565.1
      UniProtKB/Swiss-Prot
      B3KUE3, B4DE86, B7WP11, B7WPD5, D3DS07, D3DS10, Q567T1, Q68DW2, Q86U08, Q86U46, Q96FD3, Q96FT0, Q96JU0, Q96PN0, Q9BQH5, Q9ULH2, Q9UN36
      UniProtKB/TrEMBL
      Q8TDR6
      Conserved Domains (1) summary
      pfam03096
      Location:40318
      Ndr; Ndr family
    10. NM_001354560.2NP_001341489.1  protein NDRG2 isoform h

      Status: REVIEWED

      Source sequence(s)
      AL161668
      UniProtKB/TrEMBL
      Q8TDR6
      Conserved Domains (1) summary
      pfam03096
      Location:26293
      Ndr; Ndr family
    11. NM_001354561.2NP_001341490.1  protein NDRG2 isoform b

      Status: REVIEWED

      Source sequence(s)
      AL161668
      Consensus CDS
      CCDS9564.1
      UniProtKB/TrEMBL
      Q8TDR6
      Conserved Domains (1) summary
      pfam03096
      Location:26304
      Ndr; Ndr family
    12. NM_001354562.2NP_001341491.1  protein NDRG2 isoform a

      Status: REVIEWED

      Source sequence(s)
      AL161668
      Consensus CDS
      CCDS9565.1
      UniProtKB/Swiss-Prot
      B3KUE3, B4DE86, B7WP11, B7WPD5, D3DS07, D3DS10, Q567T1, Q68DW2, Q86U08, Q86U46, Q96FD3, Q96FT0, Q96JU0, Q96PN0, Q9BQH5, Q9ULH2, Q9UN36
      UniProtKB/TrEMBL
      Q8TDR6
      Conserved Domains (1) summary
      pfam03096
      Location:40318
      Ndr; Ndr family
    13. NM_001354564.2NP_001341493.1  protein NDRG2 isoform i

      Status: REVIEWED

      Source sequence(s)
      AL161668
      UniProtKB/TrEMBL
      G3V5H8
      Related
      ENSP00000452362.1, ENST00000556974.5
      Conserved Domains (1) summary
      pfam03096
      Location:40299
      Ndr; Ndr family
    14. NM_001354565.2NP_001341494.1  protein NDRG2 isoform a

      Status: REVIEWED

      Source sequence(s)
      AL161668
      Consensus CDS
      CCDS9565.1
      UniProtKB/Swiss-Prot
      B3KUE3, B4DE86, B7WP11, B7WPD5, D3DS07, D3DS10, Q567T1, Q68DW2, Q86U08, Q86U46, Q96FD3, Q96FT0, Q96JU0, Q96PN0, Q9BQH5, Q9ULH2, Q9UN36
      UniProtKB/TrEMBL
      Q8TDR6
      Conserved Domains (1) summary
      pfam03096
      Location:40318
      Ndr; Ndr family
    15. NM_001354566.1NP_001341495.1  protein NDRG2 isoform a

      Status: REVIEWED

      Source sequence(s)
      AL161668
      Consensus CDS
      CCDS9565.1
      UniProtKB/Swiss-Prot
      B3KUE3, B4DE86, B7WP11, B7WPD5, D3DS07, D3DS10, Q567T1, Q68DW2, Q86U08, Q86U46, Q96FD3, Q96FT0, Q96JU0, Q96PN0, Q9BQH5, Q9ULH2, Q9UN36
      UniProtKB/TrEMBL
      Q8TDR6
      Conserved Domains (1) summary
      pfam03096
      Location:40318
      Ndr; Ndr family
    16. NM_001354567.2NP_001341496.1  protein NDRG2 isoform a

      Status: REVIEWED

      Source sequence(s)
      AL161668
      Consensus CDS
      CCDS9565.1
      UniProtKB/Swiss-Prot
      B3KUE3, B4DE86, B7WP11, B7WPD5, D3DS07, D3DS10, Q567T1, Q68DW2, Q86U08, Q86U46, Q96FD3, Q96FT0, Q96JU0, Q96PN0, Q9BQH5, Q9ULH2, Q9UN36
      UniProtKB/TrEMBL
      Q8TDR6
      Conserved Domains (1) summary
      pfam03096
      Location:40318
      Ndr; Ndr family
    17. NM_001354568.2NP_001341497.1  protein NDRG2 isoform b

      Status: REVIEWED

      Source sequence(s)
      AL161668
      Consensus CDS
      CCDS9564.1
      UniProtKB/TrEMBL
      Q8TDR6
      Conserved Domains (1) summary
      pfam03096
      Location:26304
      Ndr; Ndr family
    18. NM_001354569.1NP_001341498.1  protein NDRG2 isoform b

      Status: REVIEWED

      Source sequence(s)
      AL161668
      Consensus CDS
      CCDS9564.1
      UniProtKB/TrEMBL
      Q8TDR6
      Conserved Domains (1) summary
      pfam03096
      Location:26304
      Ndr; Ndr family
    19. NM_001354570.2NP_001341499.1  protein NDRG2 isoform a

      Status: REVIEWED

      Source sequence(s)
      AL161668
      Consensus CDS
      CCDS9565.1
      UniProtKB/Swiss-Prot
      B3KUE3, B4DE86, B7WP11, B7WPD5, D3DS07, D3DS10, Q567T1, Q68DW2, Q86U08, Q86U46, Q96FD3, Q96FT0, Q96JU0, Q96PN0, Q9BQH5, Q9ULH2, Q9UN36
      UniProtKB/TrEMBL
      Q8TDR6
      Conserved Domains (1) summary
      pfam03096
      Location:40318
      Ndr; Ndr family
    20. NM_016250.3NP_057334.1  protein NDRG2 isoform b

      See identical proteins and their annotated locations for NP_057334.1

      Status: REVIEWED

      Source sequence(s)
      AF304051, AL136574
      Consensus CDS
      CCDS9564.1
      UniProtKB/TrEMBL
      Q8TDR6
      Related
      ENSP00000344620.3, ENST00000350792.7
      Conserved Domains (1) summary
      pfam03096
      Location:26304
      Ndr; Ndr family
    21. NM_201535.2NP_963293.1  protein NDRG2 isoform a

      See identical proteins and their annotated locations for NP_963293.1

      Status: REVIEWED

      Source sequence(s)
      AF304051, AL136574
      Consensus CDS
      CCDS9565.1
      UniProtKB/Swiss-Prot
      B3KUE3, B4DE86, B7WP11, B7WPD5, D3DS07, D3DS10, Q567T1, Q68DW2, Q86U08, Q86U46, Q96FD3, Q96FT0, Q96JU0, Q96PN0, Q9BQH5, Q9ULH2, Q9UN36
      UniProtKB/TrEMBL
      Q8TDR6
      Related
      ENSP00000298687.5, ENST00000298687.9
      Conserved Domains (1) summary
      pfam03096
      Location:40318
      Ndr; Ndr family
    22. NM_201536.2NP_963294.1  protein NDRG2 isoform b

      See identical proteins and their annotated locations for NP_963294.1

      Status: REVIEWED

      Source sequence(s)
      AF304051, AL136574, CB153966
      Consensus CDS
      CCDS9564.1
      UniProtKB/TrEMBL
      Q8TDR6
      Related
      ENSP00000353649.3, ENST00000360463.7
      Conserved Domains (1) summary
      pfam03096
      Location:26304
      Ndr; Ndr family
    23. NM_201537.2NP_963831.1  protein NDRG2 isoform a

      See identical proteins and their annotated locations for NP_963831.1

      Status: REVIEWED

      Source sequence(s)
      AF304051, AL136574, CB153966
      Consensus CDS
      CCDS9565.1
      UniProtKB/Swiss-Prot
      B3KUE3, B4DE86, B7WP11, B7WPD5, D3DS07, D3DS10, Q567T1, Q68DW2, Q86U08, Q86U46, Q96FD3, Q96FT0, Q96JU0, Q96PN0, Q9BQH5, Q9ULH2, Q9UN36
      UniProtKB/TrEMBL
      Q8TDR6
      Related
      ENSP00000380956.1, ENST00000397858.5
      Conserved Domains (1) summary
      pfam03096
      Location:40318
      Ndr; Ndr family
    24. NM_201538.2NP_963832.1  protein NDRG2 isoform b

      See identical proteins and their annotated locations for NP_963832.1

      Status: REVIEWED

      Source sequence(s)
      AL161668
      Consensus CDS
      CCDS9564.1
      UniProtKB/TrEMBL
      Q8TDR6
      Related
      ENSP00000452006.1, ENST00000554143.5
      Conserved Domains (1) summary
      pfam03096
      Location:26304
      Ndr; Ndr family
    25. NM_201539.2NP_963833.1  protein NDRG2 isoform a

      See identical proteins and their annotated locations for NP_963833.1

      Status: REVIEWED

      Source sequence(s)
      AL161668
      Consensus CDS
      CCDS9565.1
      UniProtKB/Swiss-Prot
      B3KUE3, B4DE86, B7WP11, B7WPD5, D3DS07, D3DS10, Q567T1, Q68DW2, Q86U08, Q86U46, Q96FD3, Q96FT0, Q96JU0, Q96PN0, Q9BQH5, Q9ULH2, Q9UN36
      UniProtKB/TrEMBL
      Q8TDR6
      Related
      ENSP00000380949.2, ENST00000397851.6
      Conserved Domains (1) summary
      pfam03096
      Location:40318
      Ndr; Ndr family
    26. NM_201540.2NP_963834.1  protein NDRG2 isoform a

      See identical proteins and their annotated locations for NP_963834.1

      Status: REVIEWED

      Source sequence(s)
      AL161668
      Consensus CDS
      CCDS9565.1
      UniProtKB/Swiss-Prot
      B3KUE3, B4DE86, B7WP11, B7WPD5, D3DS07, D3DS10, Q567T1, Q68DW2, Q86U08, Q86U46, Q96FD3, Q96FT0, Q96JU0, Q96PN0, Q9BQH5, Q9ULH2, Q9UN36
      UniProtKB/TrEMBL
      Q8TDR6
      Related
      ENSP00000380951.3, ENST00000397853.7
      Conserved Domains (1) summary
      pfam03096
      Location:40318
      Ndr; Ndr family
    27. NM_201541.2NP_963835.1  protein NDRG2 isoform b

      See identical proteins and their annotated locations for NP_963835.1

      Status: REVIEWED

      Source sequence(s)
      AL161668
      Consensus CDS
      CCDS9564.1
      UniProtKB/TrEMBL
      Q8TDR6
      Related
      ENSP00000451966.1, ENST00000556008.5
      Conserved Domains (1) summary
      pfam03096
      Location:26304
      Ndr; Ndr family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      21016763..21070872 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      15214166..15268302 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)