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    MIR451A microRNA 451a [ Homo sapiens (human) ]

    Gene ID: 574411, updated on 9-Dec-2024

    Summary

    Official Symbol
    MIR451Aprovided by HGNC
    Official Full Name
    microRNA 451aprovided by HGNC
    Primary source
    HGNC:HGNC:32053
    See related
    Ensembl:ENSG00000284565 MIM:612071; miRBase:MI0001729; AllianceGenome:HGNC:32053
    Gene type
    ncRNA
    RefSeq status
    PROVISIONAL
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MIR451; MIRN451; mir-451a; hsa-mir-451; hsa-mir-451a
    Summary
    microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
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    Genomic context

    See MIR451A in Genome Data Viewer
    Location:
    17q11.2
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (28861369..28861440, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (29804142..29804213, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (27188387..27188458, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 222 member B Neighboring gene ribosomal protein L31 pseudogene 58 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr17:27135759-27136700 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:27139060-27139702 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:27148955-27149456 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:27149457-27149956 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:27164662-27165545 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:27169387-27169901 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8357 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:27181187-27181692 Neighboring gene H3K27ac hESC enhancers GRCh37_chr17:27181693-27182199 and GRCh37_chr17:27182200-27182705 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr17:27185111-27186310 Neighboring gene uncharacterized LOC124903966 Neighboring gene Era like 12S mitochondrial rRNA chaperone 1 Neighboring gene microRNA 451b Neighboring gene microRNA 4732 Neighboring gene microRNA 144

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Other Names

    • microRNA 451

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables mRNA 3'-UTR binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables mRNA base-pairing translational repressor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_029970.1 RNA Sequence

      Status: PROVISIONAL

      Source sequence(s)
      AC024267
      Related
      ENST00000385059.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      28861369..28861440 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      29804142..29804213 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)