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    PTGER4 prostaglandin E receptor 4 [ Homo sapiens (human) ]

    Gene ID: 5734, updated on 15-Jun-2019

    Summary

    Official Symbol
    PTGER4provided by HGNC
    Official Full Name
    prostaglandin E receptor 4provided by HGNC
    Primary source
    HGNC:HGNC:9596
    See related
    Ensembl:ENSG00000171522 MIM:601586
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    EP4; EP4R
    Summary
    The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor can activate T-cell factor signaling. It has been shown to mediate PGE2 induced expression of early growth response 1 (EGR1), regulate the level and stability of cyclooxygenase-2 mRNA, and lead to the phosphorylation of glycogen synthase kinase-3. Knockout studies in mice suggest that this receptor may be involved in the neonatal adaptation of circulatory system, osteoporosis, as well as initiation of skin immune responses. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in bone marrow (RPKM 30.5), colon (RPKM 12.1) and 18 other tissues See more
    Orthologs

    Genomic context

    See PTGER4 in Genome Data Viewer
    Location:
    5p13.1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 5 NC_000005.10 (40679930..40740936)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (40680032..40696962)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374736 Neighboring gene uncharacterized LOC105374737 Neighboring gene tetratricopeptide repeat domain 33 Neighboring gene HNF1 motif-containing MPRA enhancer 12 Neighboring gene protein kinase AMP-activated catalytic subunit alpha 1 Neighboring gene ribosomal protein L37

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    NHGRI GWAS Catalog

    Description
    A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci.
    NHGRI GWA Catalog
    A genome-wide association study identifies new susceptibility loci for non-cardia gastric cancer at 3q13.31 and 5p13.1.
    NHGRI GWA Catalog
    A genome-wide association study on a southern European population identifies a new Crohn's disease susceptibility locus at RBX1-EP300.
    NHGRI GWA Catalog
    A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci.
    NHGRI GWA Catalog
    Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
    NHGRI GWA Catalog
    Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease.
    NHGRI GWA Catalog
    Genome-wide association study of multiple sclerosis confirms a novel locus at 5p13.1.
    NHGRI GWA Catalog
    Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
    NHGRI GWA Catalog
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    NHGRI GWA Catalog
    Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility.
    NHGRI GWA Catalog
    Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.
    NHGRI GWA Catalog
    Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci.
    NHGRI GWA Catalog
    Systematic association mapping identifies NELL1 as a novel IBD disease gene.
    NHGRI GWA Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    capsid gag Prostaglandin E2 downregulates HIV-1 CA/p24 production through the EP2 and EP4 receptors PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    • Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
      Class A/1 (Rhodopsin-like receptors), organism-specific biosystemRhodopsin-like receptors (class A/1) are the largest group of GPCRs and are the best studied group from a functional and structural point of view. They show great diversity at the sequence level and ...
    • Eicosanoid ligand-binding receptors, organism-specific biosystem (from REACTOME)
      Eicosanoid ligand-binding receptors, organism-specific biosystemEicosanoids, derived from polyunsaturated 20-carbon fatty acids, are paracrine and autocrine regulators of inflammation, smooth muscle contraction, and blood coagulation. The actions of eicosanoids a...
    • G alpha (s) signalling events, organism-specific biosystem (from REACTOME)
      G alpha (s) signalling events, organism-specific biosystemThe general function of the G alpha (s) subunit (Gs) is to activate adenylate cyclase, which in turn produces cAMP, leading to the activation of cAMP-dependent protein kinases (often referred to col...
    • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
      GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
    • GPCR ligand binding, organism-specific biosystem (from REACTOME)
      GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
    • GPCRs, Class A Rhodopsin-like, organism-specific biosystem (from WikiPathways)
      GPCRs, Class A Rhodopsin-like, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.gpcr.org/7tm/ (originally at http://www.cmbi.kun.nl/7tm/). The groupings are based on the GPCR phylogenetic tree available fr...
    • Inflammatory mediator regulation of TRP channels, organism-specific biosystem (from KEGG)
      Inflammatory mediator regulation of TRP channels, organism-specific biosystemThe TRP channels that exhibit a unique response to temperature have been given the name thermo-TRPs. Among all thermo- TRP channels, TRPV1-4, TRPM8, and TRPA1 are expressed in subsets of nociceptive...
    • Inflammatory mediator regulation of TRP channels, conserved biosystem (from KEGG)
      Inflammatory mediator regulation of TRP channels, conserved biosystemThe TRP channels that exhibit a unique response to temperature have been given the name thermo-TRPs. Among all thermo- TRP channels, TRPV1-4, TRPM8, and TRPA1 are expressed in subsets of nociceptive...
    • Neuroactive ligand-receptor interaction, organism-specific biosystem (from KEGG)
      Neuroactive ligand-receptor interaction, organism-specific biosystem
      Neuroactive ligand-receptor interaction
    • Neuroactive ligand-receptor interaction, conserved biosystem (from KEGG)
      Neuroactive ligand-receptor interaction, conserved biosystem
      Neuroactive ligand-receptor interaction
    • Pathways in cancer, organism-specific biosystem (from KEGG)
      Pathways in cancer, organism-specific biosystem
      Pathways in cancer
    • Prostaglandin Synthesis and Regulation, organism-specific biosystem (from WikiPathways)
      Prostaglandin Synthesis and Regulation, organism-specific biosystemA prostaglandin is any member of a group of lipid compounds that are derived enzymatically from fatty acids and have important functions in the animal body. Every prostaglandin contains 20 carbon ato...
    • Prostanoid ligand receptors, organism-specific biosystem (from REACTOME)
      Prostanoid ligand receptors, organism-specific biosystemFatty acid cyclo-oxygenase (COX) converts arachidonic acid to prostaglandin H2 (PGH2) from which the prostanoids PGD2, PGE2, PGF2alpha, PGI2 (prostacyclin) and thromboxane A2 (TXA2) are derived. Base...
    • Renin secretion, organism-specific biosystem (from KEGG)
      Renin secretion, organism-specific biosystemThe aspartyl-protease renin is the key regulator of the renin-angiotensin-aldosterone system, which is critically involved in extracellular fluid volume and blood pressure homeostasis of the body. R...
    • Renin secretion, conserved biosystem (from KEGG)
      Renin secretion, conserved biosystemThe aspartyl-protease renin is the key regulator of the renin-angiotensin-aldosterone system, which is critically involved in extracellular fluid volume and blood pressure homeostasis of the body. R...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by GPCR, organism-specific biosystem (from REACTOME)
      Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
    • Small Ligand GPCRs, organism-specific biosystem (from WikiPathways)
      Small Ligand GPCRs, organism-specific biosystem
      Small Ligand GPCRs

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC126583

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    prostaglandin E receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    prostaglandin E receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    ERK1 and ERK2 cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    JNK cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    T-helper cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    adenylate cyclase-modulating G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    bone development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cellular response to mechanical stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cellular response to prostaglandin E stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    immune response IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of cytokine secretion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of eosinophil extravasation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of inflammatory response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of integrin activation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cytokine secretion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of cytosolic calcium ion concentration IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of inflammatory response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of ossification IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of stress fiber assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    response to lipopolysaccharide IEA
    Inferred from Electronic Annotation
    more info
     
    response to mechanical stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    integral component of membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    prostaglandin E2 receptor EP4 subtype
    Names
    PGE receptor, EP4 subtype
    PGE2 receptor EP4 subtype
    prostaglandin E receptor 4 (subtype EP4)
    prostanoid EP4 receptor

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_047000.1 RefSeqGene

      Range
      5433..19238
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000958.3NP_000949.1  prostaglandin E2 receptor EP4 subtype

      See identical proteins and their annotated locations for NP_000949.1

      Status: REVIEWED

      Source sequence(s)
      AC093264, BC027934, BM312677, BQ029720, CD000197, L28175
      Consensus CDS
      CCDS3930.1
      UniProtKB/Swiss-Prot
      P35408
      UniProtKB/TrEMBL
      A0PJF5
      Related
      ENSP00000302846.3, ENST00000302472.4
      Conserved Domains (1) summary
      cd15142
      Location:18341
      7tmA_PGE2_EP4; prostaglandin E2 receptor EP4 subtype, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

      Range
      40679915..40740936
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017009659.2XP_016865148.1  prostaglandin E2 receptor EP4 subtype isoform X4

      Conserved Domains (2) summary
      pfam00001
      Location:34222
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:29216
      7tm_4; Olfactory receptor
    2. XM_017009656.2XP_016865145.1  prostaglandin E2 receptor EP4 subtype isoform X1

      Conserved Domains (2) summary
      pfam00001
      Location:34222
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:29216
      7tm_4; Olfactory receptor
    3. XM_017009657.1XP_016865146.1  prostaglandin E2 receptor EP4 subtype isoform X2

      Conserved Domains (2) summary
      pfam00001
      Location:34222
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:29216
      7tm_4; Olfactory receptor
    4. XM_017009658.1XP_016865147.1  prostaglandin E2 receptor EP4 subtype isoform X3

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