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    NHSL1 NHS like 1 [ Homo sapiens (human) ]

    Gene ID: 57224, updated on 17-Jun-2019

    Summary

    Official Symbol
    NHSL1provided by HGNC
    Official Full Name
    NHS like 1provided by HGNC
    Primary source
    HGNC:HGNC:21021
    See related
    Ensembl:ENSG00000135540
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C6orf63
    Expression
    Broad expression in small intestine (RPKM 4.4), colon (RPKM 3.6) and 17 other tissues See more
    Orthologs

    Genomic context

    See NHSL1 in Genome Data Viewer
    Location:
    6q24.1
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (138422043..138692616, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (138743180..138893726, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene MARCKS like 1 pseudogene 2 Neighboring gene small integral membrane protein 28 Neighboring gene heme binding protein 2 Neighboring gene microRNA 3145 Neighboring gene mitochondrial carrier 1 pseudogene Neighboring gene uncharacterized LOC441172 Neighboring gene GVQW motif containing 2 Neighboring gene coiled-coil domain containing 28A Neighboring gene epithelial cell transforming 2 like Neighboring gene ACKR4 pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA1357

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001144060.2NP_001137532.1  NHS-like protein 1 isoform 2

      See identical proteins and their annotated locations for NP_001137532.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents use of an alternate promoter and 5' UTR, uses a distinct start codon, and includes an alternate in-frame exon, compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus and includes an alternate segment, compared to isoform 1.
      Source sequence(s)
      AL391669, AL591375
      Consensus CDS
      CCDS47487.1
      UniProtKB/Swiss-Prot
      Q5SYE7
      Related
      ENSP00000344672.5, ENST00000343505.9
      Conserved Domains (1) summary
      pfam15273
      Location:255889
      NHS; NHS-like
    2. NM_020464.2NP_065197.1  NHS-like protein 1 isoform 1

      See identical proteins and their annotated locations for NP_065197.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AL391669, AL591375
      Consensus CDS
      CCDS55063.1
      UniProtKB/Swiss-Prot
      Q5SYE7
      Related
      ENSP00000394546.2, ENST00000427025.6
      Conserved Domains (1) summary
      pfam15273
      Location:259893
      NHS; NHS-like

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

      Range
      138422043..138692616 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011535976.1XP_011534278.1  NHS-like protein 1 isoform X13

      Conserved Domains (1) summary
      pfam15273
      Location:197831
      NHS; NHS-like
    2. XM_024446497.1XP_024302265.1  NHS-like protein 1 isoform X14

      Conserved Domains (2) summary
      pfam15273
      Location:96730
      NHS; NHS-like
      cl28033
      Location:9531354
      Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
    3. XM_017011086.2XP_016866575.1  NHS-like protein 1 isoform X1

      Conserved Domains (1) summary
      pfam15273
      Location:321955
      NHS; NHS-like
    4. XM_011535967.3XP_011534269.1  NHS-like protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011534269.1

      Conserved Domains (1) summary
      pfam15273
      Location:321955
      NHS; NHS-like
    5. XM_011535966.3XP_011534268.1  NHS-like protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011534268.1

      Conserved Domains (1) summary
      pfam15273
      Location:321955
      NHS; NHS-like
    6. XM_011535968.3XP_011534270.1  NHS-like protein 1 isoform X4

      Conserved Domains (1) summary
      pfam15273
      Location:277911
      NHS; NHS-like
    7. XM_005267062.5XP_005267119.1  NHS-like protein 1 isoform X2

      Conserved Domains (1) summary
      pfam15273
      Location:303937
      NHS; NHS-like
    8. XM_017011087.1XP_016866576.1  NHS-like protein 1 isoform X3

    9. XM_011535972.2XP_011534274.1  NHS-like protein 1 isoform X9

      Conserved Domains (1) summary
      pfam15273
      Location:259893
      NHS; NHS-like
    10. XM_017011089.1XP_016866578.1  NHS-like protein 1 isoform X12

    11. XM_011535969.2XP_011534271.1  NHS-like protein 1 isoform X5

      Conserved Domains (1) summary
      pfam15273
      Location:274908
      NHS; NHS-like
    12. XM_011535973.3XP_011534275.1  NHS-like protein 1 isoform X10

      Conserved Domains (1) summary
      pfam15273
      Location:256890
      NHS; NHS-like
    13. XM_011535970.2XP_011534272.1  NHS-like protein 1 isoform X6

      Conserved Domains (1) summary
      pfam15273
      Location:273907
      NHS; NHS-like
    14. XM_011535974.3XP_011534276.1  NHS-like protein 1 isoform X11

      Conserved Domains (1) summary
      pfam15273
      Location:256890
      NHS; NHS-like
    15. XM_011535971.2XP_011534273.1  NHS-like protein 1 isoform X8

      Conserved Domains (1) summary
      pfam15273
      Location:267901
      NHS; NHS-like
    16. XM_017011088.1XP_016866577.1  NHS-like protein 1 isoform X7

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