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    LYZL6 lysozyme like 6 [ Homo sapiens (human) ]

    Gene ID: 57151, updated on 15-Jun-2019

    Summary

    Official Symbol
    LYZL6provided by HGNC
    Official Full Name
    lysozyme like 6provided by HGNC
    Primary source
    HGNC:HGNC:29614
    See related
    Ensembl:ENSG00000275722 MIM:612751
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LYC1; LYZB; UNQ754; PRO1485; TKAL754; HEL-S-6a
    Summary
    This gene encodes a member of the C-type lysozyme/alpha-lactalbumin family. C-type lysozymes are bacteriolytic factors that play a role in host defense, whereas alpha-lactalbumins mediate lactose biosynthesis. The encoded protein contains catalytic residues characteristic of C-type lysozymes and may play a role in male reproduction. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jan 2011]
    Expression
    Restricted expression toward testis (RPKM 15.7) See more
    Orthologs

    Genomic context

    See LYZL6 in Genome Data Viewer
    Location:
    17q12
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 17 NC_000017.11 (35934518..35943710, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (34261522..34270714, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 37, member A3 pseudogene Neighboring gene RAD52 motif containing 1 Neighboring gene C-C motif chemokine ligand 16 Neighboring gene CCL15-CCL14 readthrough (NMD candidate) Neighboring gene C-C motif chemokine ligand 14

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    lysozyme activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cytolysis IEA
    Inferred from Electronic Annotation
    more info
     
    defense response to Gram-negative bacterium IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    defense response to Gram-positive bacterium IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    fertilization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    fusion of sperm to egg plasma membrane involved in single fertilization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cell surface IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    sperm midpiece ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    sperm plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    lysozyme-like protein 6
    Names
    epididymis secretory sperm binding protein Li 6a
    lysozyme B
    lysozyme homolog
    NP_001186880.1
    NP_065159.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001199951.3NP_001186880.1  lysozyme-like protein 6 precursor

      See identical proteins and their annotated locations for NP_001186880.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR, compared to variant 2. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC244100, AY742214, BC054481, BE550275, DB462957, HY024713
      Consensus CDS
      CCDS11302.1
      UniProtKB/Swiss-Prot
      O75951
      UniProtKB/TrEMBL
      A0A080YUZ6
      Related
      ENSP00000482955.1, ENST00000618542.4
      Conserved Domains (1) summary
      cd00119
      Location:22142
      LYZ1; C-type lysozyme (1, 4-beta-N-acetylmuramidase, LYZ) and alpha-lactalbumin (lactose synthase B protein, LA). They have a close evolutionary relationship and similar tertiary structure, however, functionally they are quite different. Lysozymes have ...
    2. NM_020426.4NP_065159.1  lysozyme-like protein 6 precursor

      See identical proteins and their annotated locations for NP_065159.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC244100, AY742214, BC054481, BE550275, DB462957, HY024713
      Consensus CDS
      CCDS11302.1
      UniProtKB/Swiss-Prot
      O75951
      UniProtKB/TrEMBL
      A0A080YUZ6
      Related
      ENSP00000483897.1, ENST00000615905.5
      Conserved Domains (1) summary
      cd00119
      Location:22142
      LYZ1; C-type lysozyme (1, 4-beta-N-acetylmuramidase, LYZ) and alpha-lactalbumin (lactose synthase B protein, LA). They have a close evolutionary relationship and similar tertiary structure, however, functionally they are quite different. Lysozymes have ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

      Range
      35934518..35943713 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p13 ALT_REF_LOCI_1

    Genomic

    1. NT_187614.1 Reference GRCh38.p13 ALT_REF_LOCI_1

      Range
      169050..178245 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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