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    PLAAT1 phospholipase A and acyltransferase 1 [ Homo sapiens (human) ]

    Gene ID: 57110, updated on 15-Jun-2019

    Summary

    Official Symbol
    PLAAT1provided by HGNC
    Official Full Name
    phospholipase A and acyltransferase 1provided by HGNC
    Primary source
    HGNC:HGNC:14922
    See related
    Ensembl:ENSG00000127252 MIM:606487
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    A-C1; HRSL1; HSD28; HRASLS; HRASLS1; PLA/AT1; PLAAT-1; H-REV107
    Expression
    Biased expression in testis (RPKM 17.3), thyroid (RPKM 1.8) and 3 other tissues See more
    Orthologs

    Genomic context

    See PLAAT1 in Genome Data Viewer
    Location:
    3q29
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 3 NC_000003.12 (193241128..193281639)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (192948030..193025102)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene vascular endothelial zinc finger 1 pseudogene 1 Neighboring gene uncharacterized LOC105374280 Neighboring gene uncharacterized protein MGC2889 Neighboring gene ATPase 13A5 Neighboring gene ATP13A5 antisense RNA 1 Neighboring gene ATPase 13A4 Neighboring gene ATP13A4 antisense RNA 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Acyl chain remodelling of PE, organism-specific biosystem (from REACTOME)
      Acyl chain remodelling of PE, organism-specific biosystemIn the acyl chain remodelling pathway (Lands cycle), phosphatidylethanolamine (PE) is hydrolyzed by phopholipases and subsequently reacylated by acyltransferases. These cycles modify the fatty acid ...
    • Glycerophospholipid biosynthesis, organism-specific biosystem (from REACTOME)
      Glycerophospholipid biosynthesis, organism-specific biosystemGlycerophospholipids are important structural and functional components of biological membranes and constituents of serum lipoproteins and the pulmonary surfactant. In addition, glycerophospholipids...
    • Metabolism, organism-specific biosystem (from REACTOME)
      Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
    • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
      Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
    • Phospholipid metabolism, organism-specific biosystem (from REACTOME)
      Phospholipid metabolism, organism-specific biosystemPhospholipids contain a polar head group and two long-chain fatty acyl moieties, one of which is generally unsaturated. The head group is a glycerol or serine phosphate attached to a polar group such...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    N-acylphosphatidylethanolamine metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatidylcholine metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear envelope lumen ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    phospholipase A and acyltransferase 1
    Names
    H-REV107 protein-related protein
    HRAS like suppressor
    HRAS-like suppressor 1
    phospholipase A
    phospholipase A/acyltransferase 1
    phospholipid-metabolizing enzyme A-C1
    NP_001353041.1
    NP_065119.3
    XP_011511336.1
    XP_011511337.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001366112.1NP_001353041.1  phospholipase A and acyltransferase 1

      Status: VALIDATED

      Source sequence(s)
      AC092966, AC105057
      Conserved Domains (1) summary
      pfam04970
      Location:26130
      LRAT; Lecithin retinol acyltransferase
    2. NM_020386.5NP_065119.3  phospholipase A and acyltransferase 1

      Status: VALIDATED

      Source sequence(s)
      BC048095, BX098792
      Consensus CDS
      CCDS3303.2
      Related
      ENSP00000498228.1, ENST00000650797.1
      Conserved Domains (1) summary
      pfam04970
      Location:26130
      LRAT; Lecithin retinol acyltransferase

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

      Range
      193241128..193281639
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011513035.2XP_011511337.1  phospholipase A and acyltransferase 1 isoform X2

      Conserved Domains (1) summary
      pfam04970
      Location:131235
      LRAT; Lecithin retinol acyltransferase
    2. XM_011513034.1XP_011511336.1  phospholipase A and acyltransferase 1 isoform X1

      Conserved Domains (1) summary
      pfam04970
      Location:131235
      LRAT; Lecithin retinol acyltransferase
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