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    AVEN apoptosis and caspase activation inhibitor [ Homo sapiens (human) ]

    Gene ID: 57099, updated on 15-Jun-2019

    Summary

    Official Symbol
    AVENprovided by HGNC
    Official Full Name
    apoptosis and caspase activation inhibitorprovided by HGNC
    Primary source
    HGNC:HGNC:13509
    See related
    Ensembl:ENSG00000169857 MIM:605265
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PDCD12
    Expression
    Ubiquitous expression in testis (RPKM 1.9), placenta (RPKM 1.7) and 25 other tissues See more
    Orthologs

    Genomic context

    See AVEN in Genome Data Viewer
    Location:
    15q14
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 15 NC_000015.10 (33851785..34074877, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (34158428..34331303, complement)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101928134 Neighboring gene ryanodine receptor 3 Neighboring gene complement C1q binding protein pseudogene 3 Neighboring gene cholinergic receptor muscarinic 5 Neighboring gene uncharacterized LOC107984748 Neighboring gene ribosomal protein L32 pseudogene 2 Neighboring gene ER membrane protein complex subunit 7

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    cytosol TAS
    Traceable Author Statement
    more info
     
    endomembrane system IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    cell death regulator Aven
    Names
    apoptosis, caspase activation inhibitor
    programmed cell death 12

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020371.3NP_065104.1  cell death regulator Aven

      See identical proteins and their annotated locations for NP_065104.1

      Status: VALIDATED

      Source sequence(s)
      AC069045, BC010488, BC063533, BU855198
      Consensus CDS
      CCDS10030.1
      UniProtKB/Swiss-Prot
      Q9NQS1
      Related
      ENSP00000306822.3, ENST00000306730.8

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

      Range
      33851785..34074877 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011521818.2XP_011520120.1  cell death regulator Aven isoform X1

    2. XM_024449999.1XP_024305767.1  cell death regulator Aven isoform X2

    3. XM_011521819.2XP_011520121.1  cell death regulator Aven isoform X2

    4. XM_011521820.1XP_011520122.1  cell death regulator Aven isoform X3

    RNA

    1. XR_002957666.1 RNA Sequence

    2. XR_002957667.1 RNA Sequence

    3. XR_001751364.2 RNA Sequence

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