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    CA10 carbonic anhydrase 10 [ Homo sapiens (human) ]

    Gene ID: 56934, updated on 15-Jun-2019

    Summary

    Official Symbol
    CA10provided by HGNC
    Official Full Name
    carbonic anhydrase 10provided by HGNC
    Primary source
    HGNC:HGNC:1369
    See related
    Ensembl:ENSG00000154975 MIM:604642
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CARPX; CA-RPX; HUCEP-15
    Summary
    This gene encodes a protein that belongs to the carbonic anhydrase family of zinc metalloenzymes, which catalyze the reversible hydration of carbon dioxide in various biological processes. The protein encoded by this gene is an acatalytic member of the alpha-carbonic anhydrase subgroup, and it is thought to play a role in the central nervous system, especially in brain development. Multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in brain (RPKM 15.3), kidney (RPKM 2.4) and 2 other tissues See more
    Orthologs

    Genomic context

    See CA10 in Genome Data Viewer
    Location:
    17q21.33-q22
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 17 NC_000017.11 (51630313..52160017, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (49707674..50237377, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2073 Neighboring gene ribosomal protein L7 pseudogene 48 Neighboring gene carbonic anhydrase 10 repeat instability region Neighboring gene uncharacterized LOC105371829 Neighboring gene long intergenic non-protein coding RNA 1982

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Related articles in PubMed

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    NHGRI GWAS Catalog

    Description
    Epidemiological and genome-wide association study of gastritis or gastric ulcer in korean populations.
    NHGRI GWA Catalog
    Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans.
    NHGRI GWA Catalog
    Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
    NHGRI GWA Catalog
    Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies.
    NHGRI GWA Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    carbonate dehydratase activity IEA
    Inferred from Electronic Annotation
    more info
     
    molecular_function ND
    No biological Data available
    more info
     
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    brain development NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    cellular_component ND
    No biological Data available
    more info
     

    General protein information

    Preferred Names
    carbonic anhydrase-related protein 10
    Names
    CA-RP X
    CARP X
    carbonic anhydrase X
    carbonic anhydrase-related protein X
    cerebral protein-15
    epididymis secretory sperm binding protein

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001082533.1NP_001076002.1  carbonic anhydrase-related protein 10 precursor

      See identical proteins and their annotated locations for NP_001076002.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC005883, AW135066, BC047456, DA110822
      Consensus CDS
      CCDS32684.1
      UniProtKB/Swiss-Prot
      Q9NS85
      Related
      ENSP00000285273.4, ENST00000285273.8
      Conserved Domains (1) summary
      cd03121
      Location:46302
      alpha_CARP_X_XI_like; Carbonic anhydrase alpha related protein: groups X, XI and related proteins. This subgroup contains carbonic anhydrase related proteins (CARPs) X and XI, which have been implicated in various biological processes of the central nervous system. CARPs are ...
    2. NM_001082534.1NP_001076003.1  carbonic anhydrase-related protein 10 precursor

      See identical proteins and their annotated locations for NP_001076003.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC005883, AF288385, AW135066, DA518921
      Consensus CDS
      CCDS32684.1
      UniProtKB/Swiss-Prot
      Q9NS85
      Related
      ENSP00000390666.2, ENST00000442502.6
      Conserved Domains (1) summary
      cd03121
      Location:46302
      alpha_CARP_X_XI_like; Carbonic anhydrase alpha related protein: groups X, XI and related proteins. This subgroup contains carbonic anhydrase related proteins (CARPs) X and XI, which have been implicated in various biological processes of the central nervous system. CARPs are ...
    3. NM_020178.5NP_064563.1  carbonic anhydrase-related protein 10 precursor

      See identical proteins and their annotated locations for NP_064563.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC005883, AW135066, BC047456, DA128892
      Consensus CDS
      CCDS32684.1
      UniProtKB/Swiss-Prot
      Q9NS85
      Related
      ENSP00000405388.2, ENST00000451037.7
      Conserved Domains (1) summary
      cd03121
      Location:46302
      alpha_CARP_X_XI_like; Carbonic anhydrase alpha related protein: groups X, XI and related proteins. This subgroup contains carbonic anhydrase related proteins (CARPs) X and XI, which have been implicated in various biological processes of the central nervous system. CARPs are ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

      Range
      51630313..52160017 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017024878.2XP_016880367.1  carbonic anhydrase-related protein 10 isoform X1

      Related
      ENSP00000459619.1, ENST00000570565.5
      Conserved Domains (1) summary
      cd03121
      Location:1205
      alpha_CARP_X_XI_like; Carbonic anhydrase alpha related protein: groups X, XI and related proteins. This subgroup contains carbonic anhydrase related proteins (CARPs) X and XI, which have been implicated in various biological processes of the central nervous system. CARPs are ...
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