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    PSG3 pregnancy specific beta-1-glycoprotein 3 [ Homo sapiens (human) ]

    Gene ID: 5671, updated on 15-Jun-2019

    Summary

    Official Symbol
    PSG3provided by HGNC
    Official Full Name
    pregnancy specific beta-1-glycoprotein 3provided by HGNC
    Primary source
    HGNC:HGNC:9520
    See related
    Ensembl:ENSG00000221826 MIM:176392
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    The human pregnancy-specific glycoproteins (PSGs) are a family of proteins that are synthesized in large amounts by placental trophoblasts and released into the maternal circulation during pregnancy. Molecular cloning and analysis of several PSG genes has indicated that the PSGs form a subgroup of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily of genes. Members of the CEA family consist of a single N domain, with structural similarity to the immunoglobulin variable domains, followed by a variable number of immunoglobulin constant-like A and/or B domains. Most PSGs have an arg-gly-asp (RGD) motif, which has been shown to function as an adhesion recognition signal for several integrins, in the N-terminal domain (summary by Teglund et al., 1994 [PubMed 7851896]). For additional general information about the PSG gene family, see PSG1 (MIM 176390).[supplied by OMIM, Oct 2009]
    Expression
    Restricted expression toward placenta (RPKM 164.7) See more

    Genomic context

    See PSG3 in Genome Data Viewer
    Location:
    19q13.2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (42721642..42740516, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (43225794..43244668, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene carcinoembryonic antigen related cell adhesion molecule pseudogene 5 Neighboring gene ribosomal protein S10 pseudogene 28 Neighboring gene pregnancy specific beta-1-glycoprotein 8 Neighboring gene carcinoembryonic antigen related cell adhesion molecule pseudogene 6

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Related articles in PubMed

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Cell surface interactions at the vascular wall, organism-specific biosystem (from REACTOME)
      Cell surface interactions at the vascular wall, organism-specific biosystemLeukocyte extravasation is a rigorously controlled process that guides white cell movement from the vascular lumen to sites of tissue inflammation. The powerful adhesive interactions that are require...
    • Hemostasis, organism-specific biosystem (from REACTOME)
      Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    defense response TAS
    Traceable Author Statement
    more info
    PubMed 
    female pregnancy TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    pregnancy-specific beta-1-glycoprotein 3
    Names
    PS-beta-G-3
    PSBG-3
    carcinoembryonic antigen SG5
    pregnancy-specific glycoprotein 3

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021016.4NP_066296.2  pregnancy-specific beta-1-glycoprotein 3 precursor

      See identical proteins and their annotated locations for NP_066296.2

      Status: VALIDATED

      Source sequence(s)
      BG620196, DA833589, M93061
      Consensus CDS
      CCDS12611.1
      UniProtKB/Swiss-Prot
      Q16557
      Related
      ENSP00000332215.5, ENST00000327495.10
      Conserved Domains (4) summary
      cd05774
      Location:36138
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      smart00410
      Location:339413
      IG_like; Immunoglobulin like
      pfam13895
      Location:335413
      Ig_2; Immunoglobulin domain
      cl11960
      Location:148236
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

      Range
      42721642..42740486 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011527127.2XP_011525429.1  pregnancy-specific beta-1-glycoprotein 3 isoform X2

      Conserved Domains (3) summary
      cd05774
      Location:58160
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      smart00410
      Location:100143
      IG_like; Immunoglobulin like
      cl11960
      Location:170258
      Ig; Immunoglobulin domain
    2. XM_011527126.2XP_011525428.1  pregnancy-specific beta-1-glycoprotein 3 isoform X1

      Conserved Domains (4) summary
      cd05774
      Location:58160
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      smart00410
      Location:268342
      IG_like; Immunoglobulin like
      pfam13895
      Location:264342
      Ig_2; Immunoglobulin domain
      cl11960
      Location:170258
      Ig; Immunoglobulin domain
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