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    EIF5A2 eukaryotic translation initiation factor 5A2 [ Homo sapiens (human) ]

    Gene ID: 56648, updated on 17-Jun-2019

    Summary

    Official Symbol
    EIF5A2provided by HGNC
    Official Full Name
    eukaryotic translation initiation factor 5A2provided by HGNC
    Primary source
    HGNC:HGNC:3301
    See related
    Ensembl:ENSG00000163577 MIM:605782
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    EIF-5A2; eIF5AII
    Expression
    Ubiquitous expression in brain (RPKM 2.4), testis (RPKM 2.3) and 25 other tissues See more
    Orthologs

    Genomic context

    See EIF5A2 in Genome Data Viewer
    Location:
    3q26.2
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (170888418..170908637, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (170606204..170626426, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene RNY5 pseudogene 3 Neighboring gene ribosomal protein L22 like 1 Neighboring gene kruppel like factor 7 pseudogene 1 Neighboring gene RNA, U1 small nuclear 70, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ribosome binding IEA
    Inferred from Electronic Annotation
    more info
     
    translation elongation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    mRNA transport IEA
    Inferred from Electronic Annotation
    more info
     
    polyamine homeostasis NAS
    Non-traceable Author Statement
    more info
    PubMed 
    positive regulation of cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of translational elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of translational termination IEA
    Inferred from Electronic Annotation
    more info
     
    protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    spermatogenesis NAS
    Non-traceable Author Statement
    more info
    PubMed 
    translational frameshifting IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytosol TAS
    Traceable Author Statement
    more info
     
    endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    nuclear pore IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    eukaryotic translation initiation factor 5A-2
    Names
    eIF-5A-2
    eukaryotic initiation factor 5A

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020390.6NP_065123.1  eukaryotic translation initiation factor 5A-2

      See identical proteins and their annotated locations for NP_065123.1

      Status: VALIDATED

      Source sequence(s)
      AY205261
      Consensus CDS
      CCDS3214.1
      UniProtKB/Swiss-Prot
      Q9GZV4
      Related
      ENSP00000295822.2, ENST00000295822.7
      Conserved Domains (1) summary
      cl30809
      Location:1150
      PLN03107; eukaryotic translation initiation factor 5A; Provisional

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

      Range
      170888418..170908637 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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