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    GKN1 gastrokine 1 [ Homo sapiens (human) ]

    Gene ID: 56287, updated on 17-Jun-2019

    Summary

    Official Symbol
    GKN1provided by HGNC
    Official Full Name
    gastrokine 1provided by HGNC
    Primary source
    HGNC:HGNC:23217
    See related
    Ensembl:ENSG00000169605 MIM:606402
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FOV; CA11; AMP18; BRICD1; foveolin
    Summary
    The protein encoded by this gene is found to be down-regulated in human gastric cancer tissue as compared to normal gastric mucosa. [provided by RefSeq, Jul 2008]
    Expression
    Restricted expression toward stomach (RPKM 11425.3) See more
    Orthologs

    Genomic context

    See GKN1 in Genome Data Viewer
    Location:
    2p13.3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (68974573..68980980)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (69201705..69208112)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene gastrokine 3, pseudogene Neighboring gene gastrokine 2 Neighboring gene ANTXR cell adhesion molecule 1 Neighboring gene microRNA 3126 Neighboring gene Sharpr-MPRA regulatory region 10320

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC70354

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    digestion NAS
    Non-traceable Author Statement
    more info
    PubMed 
    positive regulation of cell division IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cellular_component ND
    No biological Data available
    more info
     
    extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    gastrokine-1
    Names
    18 kDa antrum mucosa protein
    AMP-18
    BRICHOS domain containing 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019617.3NP_062563.3  gastrokine-1

      See identical proteins and their annotated locations for NP_062563.3

      Status: REVIEWED

      Source sequence(s)
      AJ966789
      Consensus CDS
      CCDS1891.2
      UniProtKB/Swiss-Prot
      Q9NS71
      UniProtKB/TrEMBL
      Q53YU7
      Related
      ENSP00000367172.2, ENST00000377938.2
      Conserved Domains (1) summary
      smart01039
      Location:68164
      BRICHOS; The BRICHOS domain is found in a variety of proteins implicated in dementia, respiratory distress and cancer

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

      Range
      68974573..68980980
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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