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    TEX11 testis expressed 11 [ Homo sapiens (human) ]

    Gene ID: 56159, updated on 17-Jun-2024

    Summary

    Official Symbol
    TEX11provided by HGNC
    Official Full Name
    testis expressed 11provided by HGNC
    Primary source
    HGNC:HGNC:11733
    See related
    Ensembl:ENSG00000120498 MIM:300311; AllianceGenome:HGNC:11733
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TGC1; ZIP4; MZIP4; Spo22; TSGA3; ZIP4H; SPGFX2
    Summary
    This gene is X-linked and is expressed in only male germ cells. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in pancreas (RPKM 5.2), testis (RPKM 5.1) and 1 other tissue See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See TEX11 in Genome Data Viewer
    Location:
    Xq13.1
    Exon count:
    36
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (70511227..70908711, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (68944548..69342011, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (69748790..70128561, complement)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20891 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:69674628-69675054 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20893 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chrX:69696945-69697843 Neighboring gene RNA, U4 small nuclear 81, pseudogene Neighboring gene NANOG hESC enhancer GRCh37_chrX:69699902-69700403 Neighboring gene DLG3 antisense RNA 1 Neighboring gene discs large MAGUK scaffold protein 3 Neighboring gene NANOG hESC enhancer GRCh37_chrX:69728146-69728708 Neighboring gene small integral membrane protein 30-like Neighboring gene small nucleolar RNA, C/D box 3E Neighboring gene WASHC3 pseudogene 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:70150189-70150690 Neighboring gene solute carrier family 7 member 3 Neighboring gene ribosomal protein S23 pseudogene 8

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chiasma assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ectopic germ cell programmed cell death IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in fertilization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in male gonad development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in male meiosis chromosome segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in meiotic gene conversion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of developmental process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of reproductive process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in reciprocal meiotic recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in reciprocal meiotic recombination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in resolution of meiotic recombination intermediates IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in synaptonemal complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in central element IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in chromosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    colocalizes_with synaptonemal complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    testis-expressed protein 11
    Names
    ZIP4 homolog
    protein ZIP4 homolog
    testis expressed sequence 11
    testis-expressed sequence 11 protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012574.3 RefSeqGene

      Range
      5000..384771
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001003811.2NP_001003811.1  testis-expressed protein 11 isoform 1

      See identical proteins and their annotated locations for NP_001003811.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK057523, BC036016, BG219070, BU929507
      Consensus CDS
      CCDS35323.1
      UniProtKB/Swiss-Prot
      A8K8V6, Q5JQQ8, Q8IYF3, Q96LZ4, Q96M47, Q9BXU6
      Related
      ENSP00000379226.2, ENST00000395889.6
      Conserved Domains (2) summary
      sd00006
      Location:417451
      TPR; TPR repeat [structural motif]
      pfam08631
      Location:190444
      SPO22; Meiosis protein SPO22/ZIP4 like
    2. NM_031276.3NP_112566.2  testis-expressed protein 11 isoform 2

      See identical proteins and their annotated locations for NP_112566.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an exon in the 5' region, as compared to variant 1. It uses an upstream in-frame AUG codon and encodes isoform 2 which has a shorter and distinct N-terminus, as compared to isoform 1.
      Source sequence(s)
      AK057391, AK057523, BC036016, BG219070, BU929507
      Consensus CDS
      CCDS43968.1
      UniProtKB/Swiss-Prot
      Q8IYF3
      Related
      ENSP00000363453.2, ENST00000374333.7
      Conserved Domains (2) summary
      sd00006
      Location:402436
      TPR; TPR repeat [structural motif]
      pfam08631
      Location:175429
      SPO22; Meiosis protein SPO22/ZIP4 like

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      70511227..70908711 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017029649.1XP_016885138.1  testis-expressed protein 11 isoform X1

    2. XM_017029650.1XP_016885139.1  testis-expressed protein 11 isoform X3

    3. XM_017029651.2XP_016885140.1  testis-expressed protein 11 isoform X4

      Related
      ENSP00000363440.2, ENST00000374320.6
    4. XM_017029652.2XP_016885141.1  testis-expressed protein 11 isoform X5

    5. XM_011530994.2XP_011529296.1  testis-expressed protein 11 isoform X2

      Conserved Domains (2) summary
      sd00006
      Location:402436
      TPR; TPR repeat [structural motif]
      pfam08631
      Location:175429
      SPO22; Meiosis protein SPO22/ZIP4 like

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      68944548..69342011 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054327403.1XP_054183378.1  testis-expressed protein 11 isoform X1

    2. XM_054327405.1XP_054183380.1  testis-expressed protein 11 isoform X3

    3. XM_054327406.1XP_054183381.1  testis-expressed protein 11 isoform X4

    4. XM_054327407.1XP_054183382.1  testis-expressed protein 11 isoform X5

    5. XM_054327404.1XP_054183379.1  testis-expressed protein 11 isoform X2