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    PCDHB8 protocadherin beta 8 [ Homo sapiens (human) ]

    Gene ID: 56128, updated on 15-Jun-2019

    Summary

    Official Symbol
    PCDHB8provided by HGNC
    Official Full Name
    protocadherin beta 8provided by HGNC
    Primary source
    HGNC:HGNC:8693
    See related
    Ensembl:ENSG00000120322 MIM:606334
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PCDH3I; PCDH-BETA8
    Summary
    This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3' exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical role in the establishment and function of specific cell-cell neural connections. [provided by RefSeq, Jul 2008]
    Orthologs

    Genomic context

    See PCDHB8 in Genome Data Viewer
    Location:
    5q31.3
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 5 NC_000005.10 (141177790..141180500)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (140557371..140560081)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene protocadherin beta cluster Neighboring gene protocadherin beta 17 pseudogene Neighboring gene protocadherin beta 7 Neighboring gene protocadherin beta 16 Neighboring gene protocadherin beta 9

    Genomic regions, transcripts, and products

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of protocadherin beta 8 (PCDHB8) by siRNA enhances the early stages of HIV-1 replication in HeLa-CD4 cells infected with viral pseudotypes HIV89.6R and HIV8.2N PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    calcium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    identical protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    homophilic cell adhesion via plasma membrane adhesion molecules IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    protocadherin beta-8
    Names
    protocadherin-3i

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_000017.2 

      Range
      145923..148633
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_019120.5NP_061993.3  protocadherin beta-8 precursor

      See identical proteins and their annotated locations for NP_061993.3

      Status: REVIEWED

      Source sequence(s)
      AC244517, BC136801
      Consensus CDS
      CCDS4250.1
      UniProtKB/Swiss-Prot
      Q9UN66
      Related
      ENSP00000239444.2, ENST00000239444.3
      Conserved Domains (3) summary
      cd11304
      Location:248344
      Cadherin_repeat; Cadherin tandem repeat domain
      pfam08266
      Location:31112
      Cadherin_2; Cadherin-like
      pfam16492
      Location:686769
      Cadherin_C_2; Cadherin cytoplasmic C-terminal

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

      Range
      141177790..141180539
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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