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    MAPK7 mitogen-activated protein kinase 7 [ Homo sapiens (human) ]

    Gene ID: 5598, updated on 24-Sep-2024

    Summary

    Official Symbol
    MAPK7provided by HGNC
    Official Full Name
    mitogen-activated protein kinase 7provided by HGNC
    Primary source
    HGNC:HGNC:6880
    See related
    Ensembl:ENSG00000166484 MIM:602521; AllianceGenome:HGNC:6880
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BMK1; ERK4; ERK5; PRKM7
    Summary
    The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is specifically activated by mitogen-activated protein kinase kinase 5 (MAP2K5/MEK5). It is involved in the downstream signaling processes of various receptor molecules including receptor type kinases, and G protein-coupled receptors. In response to extracelluar signals, this kinase translocates to cell nucleus, where it regulates gene expression by phosphorylating, and activating different transcription factors. Four alternatively spliced transcript variants of this gene encoding two distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in testis (RPKM 7.6), ovary (RPKM 7.0) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See MAPK7 in Genome Data Viewer
    Location:
    17p11.2
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (19377750..19383544)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (19325785..19331579)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (19281063..19286857)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene B9 domain containing 1 Neighboring gene Sharpr-MPRA regulatory region 2588 Neighboring gene microRNA 1180 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:19261015-19261514 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11856 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8288 Neighboring gene uncharacterized LOC105371573 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:19266095-19266879 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8289 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:19275949-19276498 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8290 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11858 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8291 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8292 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:19283774-19284736 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:19285982-19286482 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:19286483-19286983 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:19288791-19289336 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:19289337-19289882 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:19289883-19290428 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:19294419-19295332 Neighboring gene microfibril associated protein 4 Neighboring gene uncharacterized LOC124903947 Neighboring gene ring finger protein 112

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 binding to CD4 results in activation of the mitogen-activated protein kinase (MAPK) in CD4(+) lymphocytes prestimulated through their T-cell receptor (TCR) PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables MAP kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables enzyme inhibitor activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables mitogen-activated protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in MAPK cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in calcineurin-NFAT signaling cascade IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to growth factor stimulus IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in cellular response to hydrogen peroxide IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to laminar fluid shear stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to laminar fluid shear stress TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in cellular response to transforming growth factor beta stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of calcineurin-NFAT signaling cascade IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of endothelial cell apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of heterotypic cell-cell adhesion IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of inflammatory response TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of response to cytokine stimulus IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of smooth muscle cell apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of protein metabolic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in PML body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    mitogen-activated protein kinase 7
    Names
    BMK-1
    BMK1 kinase
    ERK-5
    MAP kinase 7
    MAPK 7
    big MAP kinase 1
    extracellular-signal-regulated kinase 5
    NP_002740.2
    NP_620601.1
    NP_620602.2
    NP_620603.2
    XP_006721620.1
    XP_006721621.1
    XP_006721622.1
    XP_011522259.1
    XP_047292357.1
    XP_047292358.1
    XP_047292359.1
    XP_047292360.1
    XP_047292361.1
    XP_047292362.1
    XP_047292363.1
    XP_054172645.1
    XP_054172646.1
    XP_054172647.1
    XP_054172648.1
    XP_054172649.1
    XP_054172650.1
    XP_054172651.1
    XP_054172652.1
    XP_054172653.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_002749.4NP_002740.2  mitogen-activated protein kinase 7 isoform 1

      See identical proteins and their annotated locations for NP_002740.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) is also known as BMK1 gamma. It differs in the 5' UTR, as compared to variant 1. Variants 1, 3 and 4 encode the same isoform.
      Source sequence(s)
      BC009963, BC030134, DA452383
      Consensus CDS
      CCDS11206.1
      UniProtKB/Swiss-Prot
      Q13164, Q16634, Q59F50, Q6QLU7, Q7L4P4, Q969G1, Q96G51
      UniProtKB/TrEMBL
      B4DI23
      Related
      ENSP00000378968.3, ENST00000395604.8
      Conserved Domains (2) summary
      smart00220
      Location:55347
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07855
      Location:49384
      STKc_ERK5; Catalytic domain of the Serine/Threonine Kinase, Extracellular signal-Regulated Kinase 5
    2. NM_139032.3NP_620601.1  mitogen-activated protein kinase 7 isoform 2

      See identical proteins and their annotated locations for NP_620601.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks a segment in the 5' region, which includes the translation start codon, when compared to variant 1. The translation of this transcript begins at a downstream in-frame start codon, and thus results in an N-terminal truncated isoform (2), as compared to isoform 1.
      Source sequence(s)
      BC007404, BC030134, DB133227
      Consensus CDS
      CCDS11207.1
      UniProtKB/Swiss-Prot
      Q13164
      Related
      ENSP00000299612.7, ENST00000299612.11
      Conserved Domains (2) summary
      smart00220
      Location:4208
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:1245
      PKc_like; Protein Kinases, catalytic domain
    3. NM_139033.3NP_620602.2  mitogen-activated protein kinase 7 isoform 1

      See identical proteins and their annotated locations for NP_620602.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) is also known as BMK1 alpha. It encodes a longer isoform (1), as compared to variant 2. Variants 1, 3 and 4 encode the same isoform.
      Source sequence(s)
      BC030134, DB133227, U29725
      Consensus CDS
      CCDS11206.1
      UniProtKB/Swiss-Prot
      Q13164, Q16634, Q59F50, Q6QLU7, Q7L4P4, Q969G1, Q96G51
      UniProtKB/TrEMBL
      B4DI23
      Related
      ENSP00000311005.5, ENST00000308406.9
      Conserved Domains (2) summary
      smart00220
      Location:55347
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07855
      Location:49384
      STKc_ERK5; Catalytic domain of the Serine/Threonine Kinase, Extracellular signal-Regulated Kinase 5
    4. NM_139034.3NP_620603.2  mitogen-activated protein kinase 7 isoform 1

      See identical proteins and their annotated locations for NP_620603.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) is also known as BMK1 beta. It differs in the 5' UTR, as compared to variant 1. Variants 1, 3 and 4 encode the same isoform.
      Source sequence(s)
      BC030134, U29726
      Consensus CDS
      CCDS11206.1
      UniProtKB/Swiss-Prot
      Q13164, Q16634, Q59F50, Q6QLU7, Q7L4P4, Q969G1, Q96G51
      UniProtKB/TrEMBL
      B4DI23
      Related
      ENSP00000378966.4, ENST00000395602.8
      Conserved Domains (2) summary
      smart00220
      Location:55347
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07855
      Location:49384
      STKc_ERK5; Catalytic domain of the Serine/Threonine Kinase, Extracellular signal-Regulated Kinase 5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      19377750..19383544
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006721558.4XP_006721621.1  mitogen-activated protein kinase 7 isoform X1

      See identical proteins and their annotated locations for XP_006721621.1

      UniProtKB/TrEMBL
      B4DI23
      Conserved Domains (2) summary
      smart00220
      Location:55353
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07855
      Location:49390
      STKc_ERK5; Catalytic domain of the Serine/Threonine Kinase, Extracellular signal-Regulated Kinase 5
    2. XM_047436404.1XP_047292360.1  mitogen-activated protein kinase 7 isoform X2

      UniProtKB/Swiss-Prot
      Q13164, Q16634, Q59F50, Q6QLU7, Q7L4P4, Q969G1, Q96G51
      UniProtKB/TrEMBL
      B4DI23
      Related
      ENST00000490660.2
    3. XM_047436402.1XP_047292358.1  mitogen-activated protein kinase 7 isoform X1

      UniProtKB/TrEMBL
      B4DI23
    4. XM_047436406.1XP_047292362.1  mitogen-activated protein kinase 7 isoform X2

      UniProtKB/Swiss-Prot
      Q13164, Q16634, Q59F50, Q6QLU7, Q7L4P4, Q969G1, Q96G51
      UniProtKB/TrEMBL
      B4DI23
    5. XM_006721557.4XP_006721620.1  mitogen-activated protein kinase 7 isoform X1

      See identical proteins and their annotated locations for XP_006721620.1

      UniProtKB/TrEMBL
      B4DI23
      Conserved Domains (2) summary
      smart00220
      Location:55353
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07855
      Location:49390
      STKc_ERK5; Catalytic domain of the Serine/Threonine Kinase, Extracellular signal-Regulated Kinase 5
    6. XM_047436403.1XP_047292359.1  mitogen-activated protein kinase 7 isoform X1

      UniProtKB/TrEMBL
      B4DI23
    7. XM_047436405.1XP_047292361.1  mitogen-activated protein kinase 7 isoform X2

      UniProtKB/Swiss-Prot
      Q13164, Q16634, Q59F50, Q6QLU7, Q7L4P4, Q969G1, Q96G51
      UniProtKB/TrEMBL
      B4DI23
    8. XM_006721559.4XP_006721622.1  mitogen-activated protein kinase 7 isoform X1

      See identical proteins and their annotated locations for XP_006721622.1

      UniProtKB/TrEMBL
      B4DI23
      Conserved Domains (2) summary
      smart00220
      Location:55353
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07855
      Location:49390
      STKc_ERK5; Catalytic domain of the Serine/Threonine Kinase, Extracellular signal-Regulated Kinase 5
    9. XM_011523957.4XP_011522259.1  mitogen-activated protein kinase 7 isoform X4

      See identical proteins and their annotated locations for XP_011522259.1

      UniProtKB/Swiss-Prot
      Q13164
      Conserved Domains (2) summary
      smart00220
      Location:4208
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:1245
      PKc_like; Protein Kinases, catalytic domain
    10. XM_047436407.1XP_047292363.1  mitogen-activated protein kinase 7 isoform X3

      UniProtKB/TrEMBL
      B4DI23
    11. XM_047436401.1XP_047292357.1  mitogen-activated protein kinase 7 isoform X1

      UniProtKB/TrEMBL
      B4DI23

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      19325785..19331579
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054316672.1XP_054172647.1  mitogen-activated protein kinase 7 isoform X1

      UniProtKB/TrEMBL
      B4DI23
    2. XM_054316673.1XP_054172648.1  mitogen-activated protein kinase 7 isoform X1

      UniProtKB/TrEMBL
      B4DI23
    3. XM_054316676.1XP_054172651.1  mitogen-activated protein kinase 7 isoform X2

      UniProtKB/Swiss-Prot
      Q13164, Q16634, Q59F50, Q6QLU7, Q7L4P4, Q969G1, Q96G51
      UniProtKB/TrEMBL
      B4DI23
    4. XM_054316670.1XP_054172645.1  mitogen-activated protein kinase 7 isoform X1

      UniProtKB/TrEMBL
      B4DI23
    5. XM_054316674.1XP_054172649.1  mitogen-activated protein kinase 7 isoform X1

      UniProtKB/TrEMBL
      B4DI23
    6. XM_054316675.1XP_054172650.1  mitogen-activated protein kinase 7 isoform X2

      UniProtKB/Swiss-Prot
      Q13164, Q16634, Q59F50, Q6QLU7, Q7L4P4, Q969G1, Q96G51
      UniProtKB/TrEMBL
      B4DI23
    7. XM_054316671.1XP_054172646.1  mitogen-activated protein kinase 7 isoform X1

      UniProtKB/TrEMBL
      B4DI23
    8. XM_054316678.1XP_054172653.1  mitogen-activated protein kinase 7 isoform X4

    9. XM_054316677.1XP_054172652.1  mitogen-activated protein kinase 7 isoform X3

      UniProtKB/TrEMBL
      B4DI23