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    INKA2 inka box actin regulator 2 [ Homo sapiens (human) ]

    Gene ID: 55924, updated on 17-Jun-2019

    Summary

    Official Symbol
    INKA2provided by HGNC
    Official Full Name
    inka box actin regulator 2provided by HGNC
    Primary source
    HGNC:HGNC:28045
    See related
    Ensembl:ENSG00000197852
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FAM212B; C1orf183
    Expression
    Ubiquitous expression in brain (RPKM 6.5), heart (RPKM 3.4) and 23 other tissues See more
    Orthologs

    Genomic context

    See INKA2 in Genome Data Viewer
    Location:
    1p13.2
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (111722064..111755797, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (112264686..112298419, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene RAP1A, member of RAS oncogene family Neighboring gene RNA, U6 small nuclear 151, pseudogene Neighboring gene keratin 18 pseudogene 57 Neighboring gene uncharacterized LOC101928718 Neighboring gene INKA2 antisense RNA 1 Neighboring gene DEAD-box helicase 20 Neighboring gene potassium voltage-gated channel subfamily D member 3 Neighboring gene KCND3 intronic transcript 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ31105

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein serine/threonine kinase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein serine/threonine kinase inhibitor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    negative regulation of protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    PAK4-inhibitor INKA2
    Names
    HInca-r
    family with sequence similarity 212 member B
    induced in neural crest by AP2-alpha protein-related homolog
    protein FAM212B

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019099.5NP_061972.1  PAK4-inhibitor INKA2 isoform 1

      See identical proteins and their annotated locations for NP_061972.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AL049557, DA306915
      Consensus CDS
      CCDS841.1
      UniProtKB/Swiss-Prot
      Q9NTI7
      Related
      ENSP00000349805.5, ENST00000357260.6
      Conserved Domains (1) summary
      pfam15342
      Location:136175
      FAM212; FAM212 family
    2. NM_198926.2NP_945120.1  PAK4-inhibitor INKA2 isoform 2

      See identical proteins and their annotated locations for NP_945120.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AL049557, AL137199
      UniProtKB/Swiss-Prot
      Q9NTI7
      UniProtKB/TrEMBL
      A0A1W2PL72
      Related
      ENSP00000495703.1, ENST00000642547.1
      Conserved Domains (1) summary
      pfam15342
      Location:121160
      FAM212; FAM212 family

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

      Range
      111722064..111755797 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011541783.2XP_011540085.1  PAK4-inhibitor INKA2 isoform X1

      See identical proteins and their annotated locations for XP_011540085.1

      Conserved Domains (1) summary
      pfam15342
      Location:117156
      FAM212; FAM212 family
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