Format

Send to:

Choose Destination
    • Showing Current items.

    ZNF302 zinc finger protein 302 [ Homo sapiens (human) ]

    Gene ID: 55900, updated on 17-Jun-2019

    Summary

    Official Symbol
    ZNF302provided by HGNC
    Official Full Name
    zinc finger protein 302provided by HGNC
    Primary source
    HGNC:HGNC:13848
    See related
    Ensembl:ENSG00000089335
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HSD16; MST154; ZNF327; MSTP154; ZNF135L; ZNF140L
    Summary
    This gene encodes a member of the zinc-finger protein family. The encoded protein contains seven C2H2-type zinc fingers and a KRAB domain, but its function has yet to be determined. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2014]
    Expression
    Ubiquitous expression in ovary (RPKM 11.7), endometrium (RPKM 10.4) and 25 other tissues See more
    Orthologs

    Genomic context

    See ZNF302 in Genome Data Viewer
    Location:
    19q13.11
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (34677639..34686397)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (35168553..35177302)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene secretoglobin family 1B member 2, pseudogene Neighboring gene zinc finger protein 530-like Neighboring gene secretoglobin family 2B member 3, pseudogene Neighboring gene zinc finger protein 181 Neighboring gene zinc finger protein 599

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Pathways from BioSystems

    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
    • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
      Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    DNA-binding transcription factor activity, RNA polymerase II-specific ISA
    Inferred from Sequence Alignment
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    zinc finger protein 302
    Names
    zinc finger protein 327

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_033997.1 RefSeqGene

      Range
      5001..13759
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001012320.2NP_001012320.1  zinc finger protein 302 isoform c

      See identical proteins and their annotated locations for NP_001012320.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 3. The resulting isoform (c) has the same N- and C-termini but is shorter compared to isoform a. Variants 1, 2, 5, 8, and 9 all encode the same isoform (c).
      Source sequence(s)
      AL834318, DB066674
      Consensus CDS
      CCDS46042.1
      UniProtKB/Swiss-Prot
      Q9NR11
      Related
      ENSP00000391067.2, ENST00000457781.6
      Conserved Domains (3) summary
      smart00349
      Location:464
      KRAB; krueppel associated box
      COG5048
      Location:132348
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:287307
      ZF_C2H2; C2H2 Zn finger [structural motif]
    2. NM_001289181.1NP_001276110.1  zinc finger protein 302 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) encodes the longest isoform (a).
      Source sequence(s)
      AK131278, AL834318, DB066674
      Consensus CDS
      CCDS74330.1
      UniProtKB/Swiss-Prot
      Q9NR11
      UniProtKB/TrEMBL
      B3KY96, E7EVR1
      Related
      ENSP00000396379.2, ENST00000446502.6
      Conserved Domains (5) summary
      smart00349
      Location:48108
      KRAB; krueppel associated box
      COG5048
      Location:150392
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:331351
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:4887
      KRAB; KRAB box
      pfam13465
      Location:287312
      zf-H2C2_2; Zinc-finger double domain
    3. NM_001289182.1NP_001276111.1  zinc finger protein 302 isoform b

      See identical proteins and their annotated locations for NP_001276111.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, uses an alternate in-frame splice junction, and lacks an alternate in-frame exon compared to variant 3. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 4, 6, and 7 all encode the same isoform (b).
      Source sequence(s)
      AC020910, AL834318, DA792042, DA793666, DB066674
      Consensus CDS
      CCDS74332.1
      UniProtKB/Swiss-Prot
      Q9NR11
      UniProtKB/TrEMBL
      A0A087WYF4
      Related
      ENSP00000481754.1, ENST00000613363.4
      Conserved Domains (3) summary
      smart00349
      Location:465
      KRAB; krueppel associated box
      COG5048
      Location:133349
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:288308
      ZF_C2H2; C2H2 Zn finger [structural motif]
    4. NM_001289183.1NP_001276112.1  zinc finger protein 302 isoform c

      See identical proteins and their annotated locations for NP_001276112.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 3. The resulting isoform (c) has the same N- and C-termini but is shorter compared to isoform a. Variants 1, 2, 5, 8, and 9 all encode the same isoform (c).
      Source sequence(s)
      AL834318, DA749741, DB066674
      Consensus CDS
      CCDS46042.1
      UniProtKB/Swiss-Prot
      Q9NR11
      Conserved Domains (3) summary
      smart00349
      Location:464
      KRAB; krueppel associated box
      COG5048
      Location:132348
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:287307
      ZF_C2H2; C2H2 Zn finger [structural motif]
    5. NM_001289184.1NP_001276113.1  zinc finger protein 302 isoform b

      See identical proteins and their annotated locations for NP_001276113.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) uses an alternate in-frame splice junction and lacks an alternate in-frame exon compared to variant 3. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 4, 6, and 7 all encode the same isoform (b).
      Source sequence(s)
      AL834318, DA790162, DB066674
      Consensus CDS
      CCDS74332.1
      UniProtKB/Swiss-Prot
      Q9NR11
      UniProtKB/TrEMBL
      A0A087WYF4
      Conserved Domains (3) summary
      smart00349
      Location:465
      KRAB; krueppel associated box
      COG5048
      Location:133349
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:288308
      ZF_C2H2; C2H2 Zn finger [structural motif]
    6. NM_001289185.1NP_001276114.1  zinc finger protein 302 isoform b

      See identical proteins and their annotated locations for NP_001276114.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR, uses an alternate in-frame splice junction, and lacks an alternate in-frame exon compared to variant 3. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 4, 6, and 7 all encode the same isoform (b).
      Source sequence(s)
      AC020910, AL834318, DA297006, DB066674
      Consensus CDS
      CCDS74332.1
      UniProtKB/Swiss-Prot
      Q9NR11
      UniProtKB/TrEMBL
      A0A087WYF4
      Conserved Domains (3) summary
      smart00349
      Location:465
      KRAB; krueppel associated box
      COG5048
      Location:133349
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:288308
      ZF_C2H2; C2H2 Zn finger [structural motif]
    7. NM_001289186.1NP_001276115.1  zinc finger protein 302 isoform c

      See identical proteins and their annotated locations for NP_001276115.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 3. The resulting isoform (c) has the same N- and C-termini but is shorter compared to isoform a. Variants 1, 2, 5, 8, and 9 all encode the same isoform (c).
      Source sequence(s)
      AL834318, DA780378, DB066674
      Consensus CDS
      CCDS46042.1
      UniProtKB/Swiss-Prot
      Q9NR11
      Conserved Domains (3) summary
      smart00349
      Location:464
      KRAB; krueppel associated box
      COG5048
      Location:132348
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:287307
      ZF_C2H2; C2H2 Zn finger [structural motif]
    8. NM_001289187.2NP_001276116.1  zinc finger protein 302 isoform c

      See identical proteins and their annotated locations for NP_001276116.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 3. The resulting isoform (c) has the same N- and C-termini but is shorter compared to isoform a. Variants 1, 2, 5, 8, and 9 all encode the same isoform (c).
      Source sequence(s)
      AC020910, AL834318, DA793666, DB066674, DN997090
      Consensus CDS
      CCDS46042.1
      UniProtKB/Swiss-Prot
      Q9NR11
      Related
      ENSP00000421028.1, ENST00000505242.6
      Conserved Domains (3) summary
      smart00349
      Location:464
      KRAB; krueppel associated box
      COG5048
      Location:132348
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:287307
      ZF_C2H2; C2H2 Zn finger [structural motif]
    9. NM_001289188.2NP_001276117.1  zinc finger protein 302 isoform d

      See identical proteins and their annotated locations for NP_001276117.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (10) differs in the 5' UTR, uses an alternate in-frame splice junction, lacks an alternate in-frame exon, and uses another alternate splice junction compared to variant 3. The resulting isoform (d) lacks an alternate internal segment, contains an additional internal aa, and has a shorter and distinct C-terminus compared to isoform a. Variants 10 and 11 both encode the same isoform (d).
      Source sequence(s)
      AC020910, AK297551, AL834318, BI562204
      Consensus CDS
      CCDS74331.1
      UniProtKB/Swiss-Prot
      Q9NR11
      UniProtKB/TrEMBL
      B4DMN2
      Related
      ENSP00000424292.1, ENST00000506901.5
      Conserved Domains (2) summary
      smart00349
      Location:465
      KRAB; krueppel associated box
      pfam01352
      Location:443
      KRAB; KRAB box
    10. NM_001289189.2NP_001276118.1  zinc finger protein 302 isoform d

      See identical proteins and their annotated locations for NP_001276118.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (11) differs in the 5' UTR, uses an alternate in-frame splice junction, lacks an alternate in-frame exon, and uses another alternate splice junction compared to variant 3. The resulting isoform (d) lacks an alternate internal segment, contains an additional internal aa, and has a shorter and distinct C-terminus compared to isoform a. Variants 10 and 11 both encode the same isoform (d).
      Source sequence(s)
      AC020910, AK297551, AL834318, BG926751, DB066674
      Consensus CDS
      CCDS74331.1
      UniProtKB/Swiss-Prot
      Q9NR11
      UniProtKB/TrEMBL
      B4DMN2
      Related
      ENSP00000421201.1, ENST00000507959.5
      Conserved Domains (2) summary
      smart00349
      Location:465
      KRAB; krueppel associated box
      pfam01352
      Location:443
      KRAB; KRAB box
    11. NM_001289190.2NP_001276119.1  zinc finger protein 302 isoform e

      See identical proteins and their annotated locations for NP_001276119.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (12) differs in the 5' UTR, lacks an alternate in-frame exon, and uses an alternate splice junction compared to variant 1. The resulting isoform (e) lacks an alternate internal segment and has a shorter and distinct C-terminus compared to isoform a. Variants 12, 13, 14, and 15 all encode the same isoform (e).
      Source sequence(s)
      AC020910, AK297551, AL834318, BG926751, DA300773, DB066674
      Consensus CDS
      CCDS74333.1
      UniProtKB/Swiss-Prot
      Q9NR11
      UniProtKB/TrEMBL
      B4DMN2, D6R9Q0
      Related
      ENSP00000423460.1, ENST00000502743.5
      Conserved Domains (2) summary
      smart00349
      Location:464
      KRAB; krueppel associated box
      pfam01352
      Location:443
      KRAB; KRAB box
    12. NM_001289191.2NP_001276120.1  zinc finger protein 302 isoform e

      See identical proteins and their annotated locations for NP_001276120.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (13) differs in the 5' UTR, lacks an alternate in-frame exon, and uses an alternate splice junction compared to variant 1. The resulting isoform (e) lacks an alternate internal segment and has a shorter and distinct C-terminus compared to isoform a. Variants 12, 13, 14, and 15 all encode the same isoform (e).
      Source sequence(s)
      AC020910, AK297551, AL834318, BG926751, DA300773, HY117192
      Consensus CDS
      CCDS74333.1
      UniProtKB/Swiss-Prot
      Q9NR11
      UniProtKB/TrEMBL
      B4DMN2, D6R9Q0
      Conserved Domains (2) summary
      smart00349
      Location:464
      KRAB; krueppel associated box
      pfam01352
      Location:443
      KRAB; KRAB box
    13. NM_001289192.2NP_001276121.1  zinc finger protein 302 isoform e

      See identical proteins and their annotated locations for NP_001276121.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (14) lacks an alternate in-frame exon and uses an alternate splice junction compared to variant 1. The resulting isoform (e) lacks an alternate internal segment and has a shorter and distinct C-terminus compared to isoform a. Variants 12, 13, 14, and 15 all encode the same isoform (e).
      Source sequence(s)
      AC020910, AK297551, AL834318, BG926751, DA300773, DA487799, DB066674
      Consensus CDS
      CCDS74333.1
      UniProtKB/Swiss-Prot
      Q9NR11
      UniProtKB/TrEMBL
      B4DMN2, D6R9Q0
      Conserved Domains (2) summary
      smart00349
      Location:464
      KRAB; krueppel associated box
      pfam01352
      Location:443
      KRAB; KRAB box
    14. NM_018443.3NP_060913.2  zinc finger protein 302 isoform c

      See identical proteins and their annotated locations for NP_060913.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) lacks an alternate in-frame exon compared to variant 3. The resulting isoform (c) has the same N- and C-termini but is shorter compared to isoform a. Variants 1, 2, 5, 8, and 9 all encode the same isoform (c).
      Source sequence(s)
      AK074901, AL834318, DB066674
      Consensus CDS
      CCDS46042.1
      UniProtKB/Swiss-Prot
      Q9NR11
      UniProtKB/TrEMBL
      Q8NC84
      Related
      ENSP00000405219.2, ENST00000423823.6
      Conserved Domains (3) summary
      smart00349
      Location:464
      KRAB; krueppel associated box
      COG5048
      Location:132348
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:287307
      ZF_C2H2; C2H2 Zn finger [structural motif]
    15. NM_018675.3NP_061145.2  zinc finger protein 302 isoform e

      See identical proteins and their annotated locations for NP_061145.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (15) differs in the 5' UTR, lacks an alternate in-frame exon, and uses an alternate splice junction compared to variant 1. The resulting isoform (e) lacks an alternate internal segment and has a shorter and distinct C-terminus compared to isoform a. Variants 12, 13, 14, and 15 all encode the same isoform (e).
      Source sequence(s)
      AC020910, AF265236, AK297551, AL834318, DB066674
      Consensus CDS
      CCDS74333.1
      UniProtKB/Swiss-Prot
      Q9NR11
      UniProtKB/TrEMBL
      B4DMN2, D6R9Q0
      Related
      ENSP00000423235.1, ENST00000505365.2
      Conserved Domains (2) summary
      smart00349
      Location:464
      KRAB; krueppel associated box
      pfam01352
      Location:443
      KRAB; KRAB box

    RNA

    1. NR_110322.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (16) lacks three exons compared to variant 3. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
      Source sequence(s)
      AL834318, DA773435, DB066674

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

      Range
      34677639..34686397
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017026978.1XP_016882467.1  zinc finger protein 302 isoform X1

      Conserved Domains (3) summary
      smart00349
      Location:48109
      KRAB; krueppel associated box
      COG5048
      Location:151393
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:332352
      ZF_C2H2; C2H2 Zn finger [structural motif]
    2. XM_017026979.1XP_016882468.1  zinc finger protein 302 isoform X2

      UniProtKB/TrEMBL
      E7EVR1
      Conserved Domains (5) summary
      smart00349
      Location:48108
      KRAB; krueppel associated box
      COG5048
      Location:150392
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:331351
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:4887
      KRAB; KRAB box
      pfam13465
      Location:287312
      zf-H2C2_2; Zinc-finger double domain
    3. XM_017026986.1XP_016882475.1  zinc finger protein 302 isoform X6

      UniProtKB/TrEMBL
      B4DMN2
      Conserved Domains (2) summary
      smart00349
      Location:465
      KRAB; krueppel associated box
      pfam01352
      Location:443
      KRAB; KRAB box
    4. XM_024451607.1XP_024307375.1  zinc finger protein 302 isoform X5

      Conserved Domains (1) summary
      smart00349
      Location:48108
      KRAB; krueppel associated box
    5. XM_017026985.1XP_016882474.1  zinc finger protein 302 isoform X5

      Conserved Domains (1) summary
      smart00349
      Location:48108
      KRAB; krueppel associated box
    6. XM_024451603.1XP_024307371.1  zinc finger protein 302 isoform X1

      Conserved Domains (3) summary
      smart00349
      Location:48109
      KRAB; krueppel associated box
      COG5048
      Location:151393
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:332352
      ZF_C2H2; C2H2 Zn finger [structural motif]
    7. XM_024451605.1XP_024307373.1  zinc finger protein 302 isoform X4

      Conserved Domains (1) summary
      smart00349
      Location:48109
      KRAB; krueppel associated box
    8. XM_024451606.1XP_024307374.1  zinc finger protein 302 isoform X5

      Conserved Domains (1) summary
      smart00349
      Location:48108
      KRAB; krueppel associated box
    9. XM_017026983.1XP_016882472.1  zinc finger protein 302 isoform X4

      Conserved Domains (1) summary
      smart00349
      Location:48109
      KRAB; krueppel associated box
    10. XM_017026980.2XP_016882469.1  zinc finger protein 302 isoform X2

      UniProtKB/TrEMBL
      E7EVR1
      Conserved Domains (5) summary
      smart00349
      Location:48108
      KRAB; krueppel associated box
      COG5048
      Location:150392
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:331351
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:4887
      KRAB; KRAB box
      pfam13465
      Location:287312
      zf-H2C2_2; Zinc-finger double domain
    11. XM_011527111.3XP_011525413.1  zinc finger protein 302 isoform X6

      See identical proteins and their annotated locations for XP_011525413.1

      UniProtKB/TrEMBL
      B4DMN2
      Conserved Domains (2) summary
      smart00349
      Location:465
      KRAB; krueppel associated box
      pfam01352
      Location:443
      KRAB; KRAB box
    12. XM_017026981.2XP_016882470.1  zinc finger protein 302 isoform X2

      UniProtKB/TrEMBL
      E7EVR1
      Conserved Domains (5) summary
      smart00349
      Location:48108
      KRAB; krueppel associated box
      COG5048
      Location:150392
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:331351
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:4887
      KRAB; KRAB box
      pfam13465
      Location:287312
      zf-H2C2_2; Zinc-finger double domain
    13. XM_017026982.1XP_016882471.1  zinc finger protein 302 isoform X3

      UniProtKB/TrEMBL
      A0A087WYF4
      Conserved Domains (3) summary
      smart00349
      Location:465
      KRAB; krueppel associated box
      COG5048
      Location:133349
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:288308
      ZF_C2H2; C2H2 Zn finger [structural motif]
    14. XM_024451604.1XP_024307372.1  zinc finger protein 302 isoform X3

      Conserved Domains (3) summary
      smart00349
      Location:465
      KRAB; krueppel associated box
      COG5048
      Location:133349
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:288308
      ZF_C2H2; C2H2 Zn finger [structural motif]
    Support Center