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    PRKCZ protein kinase C zeta [ Homo sapiens (human) ]

    Gene ID: 5590, updated on 7-Jul-2024

    Summary

    Official Symbol
    PRKCZprovided by HGNC
    Official Full Name
    protein kinase C zetaprovided by HGNC
    Primary source
    HGNC:HGNC:9412
    See related
    Ensembl:ENSG00000067606 MIM:176982; AllianceGenome:HGNC:9412
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PKC2; PKC-ZETA
    Summary
    Protein kinase C (PKC) zeta is a member of the PKC family of serine/threonine kinases which are involved in a variety of cellular processes such as proliferation, differentiation and secretion. Unlike the classical PKC isoenzymes which are calcium-dependent, PKC zeta exhibits a kinase activity which is independent of calcium and diacylglycerol but not of phosphatidylserine. Furthermore, it is insensitive to typical PKC inhibitors and cannot be activated by phorbol ester. Unlike the classical PKC isoenzymes, it has only a single zinc finger module. These structural and biochemical properties indicate that the zeta subspecies is related to, but distinct from other isoenzymes of PKC. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in brain (RPKM 11.4), placenta (RPKM 8.8) and 22 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See PRKCZ in Genome Data Viewer
    Location:
    1p36.33
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (2048504..2185395)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (1484023..1620370)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (1981850..2116834)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:1950379-1950956 Neighboring gene uncharacterized LOC105378590 Neighboring gene gamma-aminobutyric acid type A receptor subunit delta Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:1974620-1975249 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 101 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 102 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:1977985-1978738 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:1978739-1979492 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 103 Neighboring gene PRKCZ divergent transcript Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_1556 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:2016670-2017668 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:2026419-2026920 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:2026921-2027420 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 46 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:2061703-2062652 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:2062653-2063602 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:2064553-2065502 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:2068353-2069301 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:2071397-2071980 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:2105285-2105451 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:2107005-2107613 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:2111308-2112266 Neighboring gene uncharacterized LOC112268219 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 47 Neighboring gene PRKCZ antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 105 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 106 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:2127179-2127845 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:2130467-2131064 Neighboring gene FA core complex associated protein 20 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:2135273-2136272 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:2136793-2136951 Neighboring gene uncharacterized LOC105378593

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide pharmacogenomic study of neurocognition as an indicator of antipsychotic treatment response in schizophrenia.
    EBI GWAS Catalog
    Hundreds of variants clustered in genomic loci and biological pathways affect human height.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 activates forward trafficking and surface clustering of NMDA receptors in membrane microdomains by a PKA-dependent phosphorylation of the NR1 C-terminal Ser897, followed by a PKC-dependent phosphorylation of Ser896 PubMed
    env Down modulation of the interaction between HIV-1 gp120 and CD4 by TPA is blocked by protein kinase C (PKC) inhibitors, suggesting PKC may play an important role in HIV-1 infection PubMed
    env c-FLIPL inhibits Bax activation via modulating PKC expression at the transcriptional level involving AP-2 during gp120 treatment PubMed
    env Induction of apoptosis in cell cultures through binding of HIV-1 gp120 or gp160 to CXCR4 involves protein kinase C, basic fibroblast growth factor, caspase-3, and the pro-apoptotic molecule Bax PubMed
    env Pre-treatment of endothelial cells with fibroblast growth factor 2 (FGF2) protects cells from HIV-1 gp120 angiotoxicity; this protection is regulated by crosstalk among the ERK, PI3K-AKT and PKC signaling pathways PubMed
    env HIV-1 gp120 increases the levels of calcium-dependent and -independent PKC isozymes; the most striking change is observed in PKC-zeta isozyme levels PubMed
    env A specific interaction between CD4 and HIV-1 gp120 is required for phosphorylation of CD4, which could involve protein kinase C PubMed
    env IL-16 induces rapid translocation of PKC from the cytosol to the membrane in CD4+ cells; PKC inhibitors completely block IL-16-induced lymphocyte migration as well as the motile response induced by HIV-1 gp120 and anti-CD4 antibody binding to CD4 PubMed
    Envelope surface glycoprotein gp160, precursor env HIV-1 gp160-induced AP-1 complex formation is dependent upon protein tyrosine phosphorylation and is abolished by inhibitors of protein kinase C, but it is unaffected by calcium channel blockers or cyclosporine A PubMed
    Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to cytoplasmic domain residues 828-848 of HIV-1 gp41 inhibits pKC-catalysed phosphorylation of a protein substrate PubMed
    env A synthetic peptide containing residues 581-597 from HIV-1 gp41 inhibits protein kinase C (pkC)-mediated phosphorylation of the CD3 gamma-chain in intact cells and directly inhibits partially purified pkC PubMed
    Pr55(Gag) gag The phosphorylation of HIV-1 Gag by PRKCI regulates HIV-1 Vpr incorporation into virions and HIV-1 replication in macrophages PubMed
    gag Immunoprecipation analysis demonstrates that PRKCZ binds HIV-1 Gag and phosphorylates Gag at position serine 487 in the p6 domain of Gag PubMed
    gag The amplified luminescent proximity homogeneous assay (AlphaScreen) identifies the interaction of HIV-1 Gag with PRKCZ PubMed
    Tat tat HIV-1 Tat increases CXCL12-induced internalization of CXCR4, and the Tat-mediated CXCR4 internalization requires activity of protein kinase C (zeta) PubMed
    tat Phospholipase C/protein kinase C signaling pathway-dependent phosphorylation of p44/42 and JNK MAP kinases participates partially in IL-1beta induction by TAT PubMed
    tat Protein kinase C is required for HIV-1 Tat-mediated transactivation of the viral LTR promoter, indicating protein kinase C regulates the process of HIV-1 transactivation and may play a role in the transition of HIV from latency to productive growth PubMed
    tat Protein kinase C phosphorylates HIV-1 Tat on serine residue 46 PubMed
    tat HIV-1 Tat activates protein kinase C, resulting in the induction of TNF-alpha, IL-6 and IL-10 expression and the secretion of MCP-1 PubMed
    Vpr vpr The phosphorylation of HIV-1 Gag at Ser487 by PRKCZ regulates HIV-1 Vpr incorporation into virions and HIV-1 replication in macrophages PubMed
    matrix gag Protein kinase C (PKC) phosphorylates HIV-1 Matrix on serine residue 111 resulting in a shift in localization of Matrix from the cytosol to the cellular membrane, suggesting a myristoyl-protein switch regulated by PKC phosphorylation PubMed
    retropepsin gag-pol Phosphorylation of human recombinant vimentin by PKC inhibits the proteolytic processing of the vimentin head domain by HIV-1 protease PubMed
    reverse transcriptase gag-pol HIV-1 RT heterodimer expressed in bacteria can be phosphorylated in vitro by several purified mammalian protein kinases including auto-activated protein kinase (PK), CKII, cytosolic protamine kinase (CPK), myelin basic protein kinase 1 (MBPK1), and PRKC PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 14-3-3 protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables diacylglycerol-dependent serine/threonine kinase activity EXP
    Inferred from Experiment
    more info
    PubMed 
    enables diacylglycerol-dependent serine/threonine kinase activity TAS
    Traceable Author Statement
    more info
     
    enables insulin receptor substrate binding IC
    Inferred by Curator
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phospholipase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables potassium channel regulator activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein-containing complex binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to insulin stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in establishment of cell polarity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in establishment or maintenance of epithelial cell apical/basal polarity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in long-term memory IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in long-term synaptic potentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in membrane depolarization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in membrane hyperpolarization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in microtubule cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of insulin receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of peptidyl-tyrosine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of protein-containing complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neuron projection extension IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in peptidyl-serine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in peptidyl-serine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of NF-kappaB transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of T-helper 2 cell cytokine production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of T-helper 2 cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cell-matrix adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of excitatory postsynaptic potential ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of insulin receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of interleukin-10 production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of interleukin-13 production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of interleukin-4 production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of interleukin-5 production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein kinase C signaling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein localization to plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in vesicle transport along microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of PAR polarity complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in Schaffer collateral - CA1 synapse IEA
    Inferred from Electronic Annotation
    more info
     
    located_in apical cortex IEA
    Inferred from Electronic Annotation
    more info
     
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in axon hillock IEA
    Inferred from Electronic Annotation
    more info
     
    located_in bicellular tight junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell junction TAS
    Traceable Author Statement
    more info
     
    located_in cell leading edge IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell-cell junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in microtubule organizing center IEA
    Inferred from Electronic Annotation
    more info
     
    located_in myelin sheath abaxonal region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear envelope IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear matrix IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
     
    located_in postsynaptic density IEA
    Inferred from Electronic Annotation
    more info
     
    located_in stress fiber IEA
    Inferred from Electronic Annotation
    more info
     
    located_in tight junction NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    protein kinase C zeta type
    Names
    nPKC-zeta
    NP_001028753.1
    NP_001028754.1
    NP_001229803.1
    NP_001337732.1
    NP_001337733.1
    NP_001337734.1
    NP_001337735.1
    NP_002735.3
    XP_011540075.1
    XP_011540076.1
    XP_011540077.1
    XP_011540078.1
    XP_016857278.1
    XP_016857279.1
    XP_016857281.1
    XP_016857282.1
    XP_016857286.1
    XP_016857291.1
    XP_016857292.1
    XP_024304159.1
    XP_024304164.1
    XP_024304165.1
    XP_047281211.1
    XP_047281216.1
    XP_047281218.1
    XP_047281229.1
    XP_047281239.1
    XP_047281260.1
    XP_047281263.1
    XP_047281279.1
    XP_047281296.1
    XP_047281304.1
    XP_054193655.1
    XP_054193656.1
    XP_054193657.1
    XP_054193658.1
    XP_054193659.1
    XP_054193660.1
    XP_054193661.1
    XP_054193662.1
    XP_054193663.1
    XP_054193664.1
    XP_054193665.1
    XP_054193666.1
    XP_054193667.1
    XP_054193668.1
    XP_054193669.1
    XP_054193670.1
    XP_054193671.1
    XP_054193672.1
    XP_054193673.1
    XP_054193674.1
    XP_054193675.1
    XP_054193676.1
    XP_054193677.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029616.1 RefSeqGene

      Range
      4942..139926
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001033581.3NP_001028753.1  protein kinase C zeta type isoform 2

      See identical proteins and their annotated locations for NP_001028753.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences cause translation initiation from a downstream ATG and an isoform (2) with a shorter N-terminus, compared to isoform 1. Variants 2 and 3 encode the same isoform (2).
      Source sequence(s)
      BC008058, CB152283
      Consensus CDS
      CCDS41229.1
      UniProtKB/TrEMBL
      B3KUN5
      Related
      ENSP00000383712.2, ENST00000400921.6
      Conserved Domains (1) summary
      cl21453
      Location:53409
      PKc_like; Protein Kinases, catalytic domain
    2. NM_001033582.3NP_001028754.1  protein kinase C zeta type isoform 2

      See identical proteins and their annotated locations for NP_001028754.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences cause translation initiation from a downstream ATG and an isoform (3) with a shorter N-terminus, compared to isoform 1. Variants 2 and 3 encode the same isoform (2).
      Source sequence(s)
      AL542576, AU134793, BC008058
      Consensus CDS
      CCDS41229.1
      UniProtKB/TrEMBL
      B3KUN5
      Conserved Domains (1) summary
      cl21453
      Location:53409
      PKc_like; Protein Kinases, catalytic domain
    3. NM_001242874.3NP_001229803.1  protein kinase C zeta type isoform 3

      See identical proteins and their annotated locations for NP_001229803.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AK294782, AL590822, BC008058, DC312466
      Consensus CDS
      CCDS55563.1
      UniProtKB/TrEMBL
      B3KUN5
      Related
      ENSP00000426412.1, ENST00000461106.6
      Conserved Domains (2) summary
      cd21095
      Location:2579
      C1_aPKC_zeta; protein kinase C conserved region 1 (C1 domain) found in the atypical protein kinase C (aPKC) zeta type
      cl21453
      Location:132488
      PKc_like; Protein Kinases, catalytic domain
    4. NM_001350803.2NP_001337732.1  protein kinase C zeta type isoform 4

      Status: REVIEWED

      Source sequence(s)
      AI186591, BC008058, BQ084132, CB152283, DA392984
      UniProtKB/TrEMBL
      B3KUN5
      Conserved Domains (1) summary
      cl21453
      Location:53417
      PKc_like; Protein Kinases, catalytic domain
    5. NM_001350804.2NP_001337733.1  protein kinase C zeta type isoform 4

      Status: REVIEWED

      Source sequence(s)
      AI186591, AL645703, BC008058, BQ084132, CB152283
      UniProtKB/TrEMBL
      B3KUN5
      Conserved Domains (1) summary
      cl21453
      Location:53417
      PKc_like; Protein Kinases, catalytic domain
    6. NM_001350805.2NP_001337734.1  protein kinase C zeta type isoform 5

      Status: REVIEWED

      Source sequence(s)
      AI186591, AL590822, BC008058, DC328654
      UniProtKB/TrEMBL
      B3KUN5
      Conserved Domains (1) summary
      cl21453
      Location:1355
      PKc_like; Protein Kinases, catalytic domain
    7. NM_001350806.2NP_001337735.1  protein kinase C zeta type isoform 5

      Status: REVIEWED

      Source sequence(s)
      AI186591, AL590822, BC008058, DC314278
      UniProtKB/TrEMBL
      B3KUN5
      Conserved Domains (1) summary
      cl21453
      Location:1355
      PKc_like; Protein Kinases, catalytic domain
    8. NM_002744.6NP_002735.3  protein kinase C zeta type isoform 1

      See identical proteins and their annotated locations for NP_002735.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AL391845, BC008058, BC014270
      Consensus CDS
      CCDS37.1
      UniProtKB/Swiss-Prot
      A8K4N0, A8MU64, B7Z2J7, E9PCW2, Q05513, Q15207, Q5SYT5, Q969S4
      Related
      ENSP00000367830.3, ENST00000378567.8
      Conserved Domains (3) summary
      cd06404
      Location:1698
      PB1_aPKC; PB1 domain is an essential modular domain of the atypical protein kinase C (aPKC) which in complex with Par6 and Par3 proteins is crucial for establishment of apical-basal polarity of animal cells. PB1 domain is a modular domain mediating specific ...
      cd05617
      Location:236592
      STKc_aPKC_zeta; Catalytic domain of the Serine/Threonine Kinase, Atypical Protein Kinase C zeta
      pfam00130
      Location:131181
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

    RNA

    1. NR_146911.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      BC008058, CB152283, HY218327

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      2048504..2185395
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047425255.1XP_047281211.1  protein kinase C zeta type isoform X4

    2. XM_017001790.2XP_016857279.1  protein kinase C zeta type isoform X2

    3. XM_017001789.2XP_016857278.1  protein kinase C zeta type isoform X1

    4. XM_011541773.2XP_011540075.1  protein kinase C zeta type isoform X3

      Conserved Domains (4) summary
      cd06404
      Location:1698
      PB1_aPKC; PB1 domain is an essential modular domain of the atypical protein kinase C (aPKC) which in complex with Par6 and Par3 proteins is crucial for establishment of apical-basal polarity of animal cells. PB1 domain is a modular domain mediating specific ...
      smart00220
      Location:252518
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      pfam00130
      Location:131181
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      cl21453
      Location:236529
      PKc_like; Protein Kinases, catalytic domain
    5. XM_011541775.4XP_011540077.1  protein kinase C zeta type isoform X13

      Conserved Domains (3) summary
      cd06404
      Location:1698
      PB1_aPKC; PB1 domain is an essential modular domain of the atypical protein kinase C (aPKC) which in complex with Par6 and Par3 proteins is crucial for establishment of apical-basal polarity of animal cells. PB1 domain is a modular domain mediating specific ...
      pfam00130
      Location:131181
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      cl21453
      Location:236325
      PKc_like; Protein Kinases, catalytic domain
    6. XM_017001803.3XP_016857292.1  protein kinase C zeta type isoform X18

    7. XM_047425262.1XP_047281218.1  protein kinase C zeta type isoform X6

    8. XM_047425260.1XP_047281216.1  protein kinase C zeta type isoform X5

    9. XM_017001792.2XP_016857281.1  protein kinase C zeta type isoform X10

      UniProtKB/TrEMBL
      E9PBE1
      Conserved Domains (1) summary
      cl21453
      Location:53354
      PKc_like; Protein Kinases, catalytic domain
    10. XM_011541776.2XP_011540078.1  protein kinase C zeta type isoform X14

      See identical proteins and their annotated locations for XP_011540078.1

      UniProtKB/TrEMBL
      E9PBE1
      Conserved Domains (1) summary
      cl21453
      Location:53346
      PKc_like; Protein Kinases, catalytic domain
    11. XM_011541774.2XP_011540076.1  protein kinase C zeta type isoform X8

      Conserved Domains (3) summary
      smart00220
      Location:148414
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      pfam00130
      Location:2777
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      cl21453
      Location:132425
      PKc_like; Protein Kinases, catalytic domain
    12. XM_047425283.1XP_047281239.1  protein kinase C zeta type isoform X9

      UniProtKB/TrEMBL
      B3KUN5
    13. XM_047425323.1XP_047281279.1  protein kinase C zeta type isoform X11

      UniProtKB/TrEMBL
      B3KUN5
    14. XM_024448391.2XP_024304159.1  protein kinase C zeta type isoform X10

      UniProtKB/TrEMBL
      E9PBE1
      Conserved Domains (1) summary
      cl21453
      Location:53354
      PKc_like; Protein Kinases, catalytic domain
    15. XM_024448396.2XP_024304164.1  protein kinase C zeta type isoform X14

      UniProtKB/TrEMBL
      E9PBE1
      Conserved Domains (1) summary
      cl21453
      Location:53346
      PKc_like; Protein Kinases, catalytic domain
    16. XM_047425348.1XP_047281304.1  protein kinase C zeta type isoform X15

      UniProtKB/TrEMBL
      B3KUN5
      Related
      ENSP00000424398.1, ENST00000478770.6
    17. XM_047425304.1XP_047281260.1  protein kinase C zeta type isoform X10

      UniProtKB/TrEMBL
      E9PBE1
    18. XM_047425340.1XP_047281296.1  protein kinase C zeta type isoform X14

      UniProtKB/TrEMBL
      E9PBE1
    19. XM_047425273.1XP_047281229.1  protein kinase C zeta type isoform X7

    20. XM_017001793.2XP_016857282.1  protein kinase C zeta type isoform X10

      UniProtKB/TrEMBL
      E9PBE1
      Conserved Domains (1) summary
      cl21453
      Location:53354
      PKc_like; Protein Kinases, catalytic domain
    21. XM_047425307.1XP_047281263.1  protein kinase C zeta type isoform X10

      UniProtKB/TrEMBL
      E9PBE1
    22. XM_017001797.2XP_016857286.1  protein kinase C zeta type isoform X12

      UniProtKB/TrEMBL
      E9PBE1
    23. XM_024448397.2XP_024304165.1  protein kinase C zeta type isoform X16

      Conserved Domains (1) summary
      cl21453
      Location:1300
      PKc_like; Protein Kinases, catalytic domain
    24. XM_017001802.2XP_016857291.1  protein kinase C zeta type isoform X17

      UniProtKB/TrEMBL
      E9PBE1

    RNA

    1. XR_007061965.1 RNA Sequence

    2. XR_007061966.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      1484023..1620370
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054337683.1XP_054193658.1  protein kinase C zeta type isoform X4

    2. XM_054337681.1XP_054193656.1  protein kinase C zeta type isoform X2

    3. XM_054337680.1XP_054193655.1  protein kinase C zeta type isoform X1

    4. XM_054337682.1XP_054193657.1  protein kinase C zeta type isoform X3

    5. XM_054337695.1XP_054193670.1  protein kinase C zeta type isoform X13

    6. XM_054337702.1XP_054193677.1  protein kinase C zeta type isoform X18

    7. XM_054337685.1XP_054193660.1  protein kinase C zeta type isoform X6

    8. XM_054337684.1XP_054193659.1  protein kinase C zeta type isoform X5

    9. XM_054337690.1XP_054193665.1  protein kinase C zeta type isoform X10

      UniProtKB/TrEMBL
      E9PBE1
    10. XM_054337696.1XP_054193671.1  protein kinase C zeta type isoform X14

      UniProtKB/TrEMBL
      E9PBE1
    11. XM_054337687.1XP_054193662.1  protein kinase C zeta type isoform X8

    12. XM_054337688.1XP_054193663.1  protein kinase C zeta type isoform X9

      UniProtKB/TrEMBL
      B3KUN5
    13. XM_054337693.1XP_054193668.1  protein kinase C zeta type isoform X11

      UniProtKB/TrEMBL
      B3KUN5
    14. XM_054337689.1XP_054193664.1  protein kinase C zeta type isoform X10

      UniProtKB/TrEMBL
      E9PBE1
    15. XM_054337697.1XP_054193672.1  protein kinase C zeta type isoform X14

      UniProtKB/TrEMBL
      E9PBE1
    16. XM_054337699.1XP_054193674.1  protein kinase C zeta type isoform X15

      UniProtKB/TrEMBL
      B3KUN5
    17. XM_054337691.1XP_054193666.1  protein kinase C zeta type isoform X10

      UniProtKB/TrEMBL
      E9PBE1
    18. XM_054337698.1XP_054193673.1  protein kinase C zeta type isoform X14

      UniProtKB/TrEMBL
      E9PBE1
    19. XM_054337686.1XP_054193661.1  protein kinase C zeta type isoform X7

    20. XM_054337692.1XP_054193667.1  protein kinase C zeta type isoform X10

      UniProtKB/TrEMBL
      E9PBE1
    21. XM_054337694.1XP_054193669.1  protein kinase C zeta type isoform X12

      UniProtKB/TrEMBL
      E9PBE1
    22. XM_054337700.1XP_054193675.1  protein kinase C zeta type isoform X16

    23. XM_054337701.1XP_054193676.1  protein kinase C zeta type isoform X17

      UniProtKB/TrEMBL
      E9PBE1

    RNA

    1. XR_008486108.1 RNA Sequence

    2. XR_008486109.1 RNA Sequence