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    MYNN myoneurin [ Homo sapiens (human) ]

    Gene ID: 55892, updated on 15-Jun-2019

    Summary

    Official Symbol
    MYNNprovided by HGNC
    Official Full Name
    myoneurinprovided by HGNC
    Primary source
    HGNC:HGNC:14955
    See related
    Ensembl:ENSG00000085274 MIM:606042
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    OSZF; SBBIZ1; ZBTB31; ZNF902
    Summary
    This gene encodes a member of the BTB/POZ and zinc finger domain-containing protein family that are involved in the control of gene expression. Alternative splicing results in multiple transcript variants and a pseudogene has been identified on chromosome 14. [provided by RefSeq, Jun 2010]
    Expression
    Ubiquitous expression in bone marrow (RPKM 4.7), testis (RPKM 4.6) and 25 other tissues See more
    Orthologs

    Genomic context

    See MYNN in Genome Data Viewer
    Location:
    3q26.2
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 3 NC_000003.12 (169772247..169790455)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (169490619..169507504)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene telomerase RNA component (TERC) promoter Neighboring gene telomerase RNA component Neighboring gene actin related protein T3 Neighboring gene tRNA-Val (anticodon AAC) 1-1 Neighboring gene leucine rich repeat containing 34 Neighboring gene leucine rich repeats and IQ motif containing 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Phenotypes

    NHGRI GWAS Catalog

    Description
    A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia.
    NHGRI GWA Catalog
    Common variation at 3q26.2, 6p21.33, 17p11.2 and 22q13.1 influences multiple myeloma risk.
    NHGRI GWA Catalog
    Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
    NHGRI GWA Catalog
    Genome-wide association study identifies multiple loci associated with bladder cancer risk.
    NHGRI GWA Catalog
    Genome-wide meta-analysis points to CTC1 and ZNF676 as genes regulating telomere homeostasis in humans.
    NHGRI GWA Catalog
    Identification of seven loci affecting mean telomere length and their association with disease.
    NHGRI GWA Catalog
    Meta-analysis of three genome-wide association studies identifies susceptibility loci for colorectal cancer at 1q41, 3q26.2, 12q13.13 and 20q13.33.
    NHGRI GWA Catalog
    Multiple common variants for celiac disease influencing immune gene expression.
    NHGRI GWA Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    DNA-binding transcription factor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    DNA-binding transcription factor activity, RNA polymerase II-specific ISA
    Inferred from Sequence Alignment
    more info
     
    zinc ion binding TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    cellular response to leukemia inhibitory factor IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    transcription, DNA-templated TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    myoneurin
    Names
    zinc finger and BTB domain-containing protein 31
    zinc finger protein with BTB/POZ domain

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001185118.2NP_001172047.1  myoneurin isoform A

      See identical proteins and their annotated locations for NP_001172047.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) includes an additional exon in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein (isoform A).
      Source sequence(s)
      AC078795, AF148848, BX648128, DB134736
      Consensus CDS
      CCDS3207.1
      UniProtKB/Swiss-Prot
      Q9NPC7
      Related
      ENSP00000349150.3, ENST00000356716.8
      Conserved Domains (5) summary
      COG5189
      Location:354438
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:304324
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:304324
      zf-C2H2; Zinc finger, C2H2 type
      pfam00651
      Location:14115
      BTB; BTB/POZ domain
      pfam13465
      Location:316341
      zf-H2C2_2; Zinc-finger double domain
    2. NM_001185119.1NP_001172048.1  myoneurin isoform B

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and lacks an in-frame exon in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform B), compared to isoform A.
      Source sequence(s)
      AB079778, AC078795, DB134736
      Consensus CDS
      CCDS54671.1
      UniProtKB/Swiss-Prot
      Q9NPC7
      Related
      ENSP00000440637.1, ENST00000544106.5
      Conserved Domains (6) summary
      COG5048
      Location:385535
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:354438
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:304324
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:304324
      zf-C2H2; Zinc finger, C2H2 type
      pfam00651
      Location:14115
      BTB; BTB/POZ domain
      pfam13465
      Location:316341
      zf-H2C2_2; Zinc-finger double domain
    3. NM_018657.5NP_061127.1  myoneurin isoform A

      See identical proteins and their annotated locations for NP_061127.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (A). Both variants 1 and 2 encode the same protein (isoform A).
      Source sequence(s)
      AC078795, BX648128, DB134736
      Consensus CDS
      CCDS3207.1
      UniProtKB/Swiss-Prot
      Q9NPC7
      Related
      ENSP00000326240.4, ENST00000349841.9
      Conserved Domains (5) summary
      COG5189
      Location:354438
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:304324
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:304324
      zf-C2H2; Zinc finger, C2H2 type
      pfam00651
      Location:14115
      BTB; BTB/POZ domain
      pfam13465
      Location:316341
      zf-H2C2_2; Zinc-finger double domain

    RNA

    1. NR_033702.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses an alternate splice site in an internal coding exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC078795, AK304281, BX648128, DB134736
    2. NR_033703.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) uses an alternate splice site in an internal coding exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC078795, AC078802, AF155508, BX648128, DB134736

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

      Range
      169773065..169789716
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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