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    DHX32 DEAH-box helicase 32 (putative) [ Homo sapiens (human) ]

    Gene ID: 55760, updated on 17-Jun-2019

    Summary

    Official Symbol
    DHX32provided by HGNC
    Official Full Name
    DEAH-box helicase 32 (putative)provided by HGNC
    Primary source
    HGNC:HGNC:16717
    See related
    Ensembl:ENSG00000089876 MIM:607960
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DDX32; DHLP1
    Summary
    DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a member of this family. The function of this member has not been determined. Alternative splicing of this gene generates 2 transcript variants, but the full length nature of one of the variants has not been defined. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in testis (RPKM 18.2), colon (RPKM 13.8) and 25 other tissues See more
    Orthologs

    Genomic context

    See DHX32 in Genome Data Viewer
    Location:
    10q26.2
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (125836337..125881292, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (127524909..127569884, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene matrix metallopeptidase 21 Neighboring gene uroporphyrinogen III synthase Neighboring gene microRNA 4484 Neighboring gene BRCA2 and CDKN1A interacting protein Neighboring gene RNA, U2 small nuclear 42, pseudogene Neighboring gene fibronectin type III and ankyrin repeat domains 1 Neighboring gene G protein subunit gamma 10 pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ10694, FLJ10889

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    3'-5' RNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32
    Names
    DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 32
    DEAD/H box 32
    DEAD/H helicase-like protein-1
    DEAH (Asp-Glu-Ala-His) box polypeptide 32
    DEAH box protein 32
    huDDX32
    NP_060650.2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_018180.3NP_060650.2  putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32

      See identical proteins and their annotated locations for NP_060650.2

      Status: REVIEWED

      Source sequence(s)
      AL360176
      Consensus CDS
      CCDS7652.1
      UniProtKB/Swiss-Prot
      Q7L7V1
      Related
      ENSP00000284690.3, ENST00000284690.3
      Conserved Domains (1) summary
      COG1643
      Location:12679
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

      Range
      125836337..125881292 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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