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    RCOR3 REST corepressor 3 [ Homo sapiens (human) ]

    Gene ID: 55758, updated on 17-Jun-2024

    Summary

    Official Symbol
    RCOR3provided by HGNC
    Official Full Name
    REST corepressor 3provided by HGNC
    Primary source
    HGNC:HGNC:25594
    See related
    Ensembl:ENSG00000117625 MIM:620464; AllianceGenome:HGNC:25594
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable enzyme binding activity and transcription corepressor activity. Predicted to be involved in histone deacetylation; negative regulation of transcription, DNA-templated; and regulation of transcription by RNA polymerase II. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis (RPKM 13.7), thyroid (RPKM 11.6) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See RCOR3 in Genome Data Viewer
    Location:
    1q32.2-q32.3
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (211259366..211316385)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (210504931..210561986)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (211432708..211489727)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene PRELID1 pseudogene 5 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:211402251-211402447 Neighboring gene uncharacterized LOC105372902 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2482 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:211431921-211432422 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:211432925-211433424 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:211498879-211499380 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2483 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1784 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2484 Neighboring gene TNF receptor associated factor 5 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1785 Neighboring gene uncharacterized LOC124904504 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr1:211550792-211551568

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ10876, FLJ16298

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in negative regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    part_of histone deacetylase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    part_of transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001136223.3NP_001129695.1  REST corepressor 3 isoform a

      See identical proteins and their annotated locations for NP_001129695.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform a.
      Source sequence(s)
      AK302664, AL590101, BU689437, HY024910
      Consensus CDS
      CCDS44312.1
      UniProtKB/Swiss-Prot
      Q9P2K3
      Related
      ENSP00000413929.2, ENST00000419091.7
      Conserved Domains (3) summary
      pfam00249
      Location:347390
      Myb_DNA-binding; Myb-like DNA-binding domain
      pfam01448
      Location:59110
      ELM2; ELM2 domain
      cl21498
      Location:146190
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    2. NM_001136224.4NP_001129696.2  REST corepressor 3 isoform b

      See identical proteins and their annotated locations for NP_001129696.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate 3' coding exon compared to variant 1, that causes a frameshift. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a.
      Source sequence(s)
      AL590101, BC031608, BU689437, DC387352, HY024910
      Consensus CDS
      CCDS44313.1
      UniProtKB/Swiss-Prot
      Q9P2K3
      Related
      ENSP00000355973.4, ENST00000367006.8
      Conserved Domains (2) summary
      pfam01448
      Location:59110
      ELM2; ELM2 domain
      cl21498
      Location:146190
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    3. NM_001136225.3NP_001129697.1  REST corepressor 3 isoform c

      See identical proteins and their annotated locations for NP_001129697.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (c) has a shorter and distinct C-terminus compared to isoform a.
      Source sequence(s)
      AA831517, AK131312, HY024910
      Consensus CDS
      CCDS44314.1
      UniProtKB/Swiss-Prot
      Q9P2K3
      Related
      ENSP00000398558.2, ENST00000452621.6
      Conserved Domains (3) summary
      pfam00249
      Location:347390
      Myb_DNA-binding; Myb-like DNA-binding domain
      pfam01448
      Location:59110
      ELM2; ELM2 domain
      cl21498
      Location:146190
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    4. NM_001350069.2NP_001336998.1  REST corepressor 3 isoform e

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) contains an alternate in-frame exon in the 5' coding region compared to variant 1. The resulting isoform (e) has the same N- and C-termini, but is longer than isoform a.
      Source sequence(s)
      AK302664, AL590101, BU689437, DA925839, HY024910
      Conserved Domains (3) summary
      pfam00249
      Location:379422
      Myb_DNA-binding; Myb-like DNA-binding domain
      pfam01448
      Location:59142
      ELM2; ELM2 domain
      cl21498
      Location:178222
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    5. NM_001350070.2NP_001336999.1  REST corepressor 3 isoform f

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) contains an alternate exon in its 5' UTR, resulting in the use of a downstream start codon compared to variant 1. The resulting isoform (f) has a shorter N-terminus compared to isoform a.
      Source sequence(s)
      AK302664, AL590101, AL611964, BU689437, DB164963, HY024910
      Conserved Domains (2) summary
      pfam00249
      Location:226269
      Myb_DNA-binding; Myb-like DNA-binding domain
      cl21498
      Location:2569
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    6. NM_018254.5NP_060724.1  REST corepressor 3 isoform d

      See identical proteins and their annotated locations for NP_060724.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (d) has a shorter N-terminus compared to isoform a.
      Source sequence(s)
      AK001738, AL590101, BU689437, DA478986
      Consensus CDS
      CCDS31016.1
      UniProtKB/Swiss-Prot
      B3KYA2, B4DYY7, Q5VT47, Q7L9I5, Q8N5U3, Q9NV83, Q9P2K3
      Related
      ENSP00000355972.4, ENST00000367005.8
      Conserved Domains (3) summary
      pfam00249
      Location:289332
      Myb_DNA-binding; Myb-like DNA-binding domain
      pfam01448
      Location:152
      ELM2; ELM2 domain
      cl21498
      Location:88132
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

    RNA

    1. NR_146432.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) uses an alternate splice site in its 5' terminal exon and contains an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD)
      Source sequence(s)
      AK302664, AL590101, BI051857, BU689437, DA334880, HY024910
    2. NR_146433.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) contains an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK302664, AL590101, BI051857, BQ218032, BU689437, DC387352, HY024910
    3. NR_146434.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9) contains an alternate internal exon, and it 3' terminal exon extends past a splice site that is used in variant 1.. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AA831517, AI380424, AK302664, BI051857, BP221223, BQ218032, DA224160, DC387352, HY024910

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      211259366..211316385
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047425046.1XP_047281002.1  REST corepressor 3 isoform X9

      UniProtKB/TrEMBL
      B4DV59
    2. XM_005273191.6XP_005273248.1  REST corepressor 3 isoform X1

      Conserved Domains (3) summary
      pfam00249
      Location:348391
      Myb_DNA-binding; Myb-like DNA-binding domain
      pfam01448
      Location:60111
      ELM2; ELM2 domain
      cl21498
      Location:147191
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    3. XM_006711442.3XP_006711505.1  REST corepressor 3 isoform X4

      Conserved Domains (3) summary
      smart00717
      Location:146192
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      pfam01448
      Location:60111
      ELM2; ELM2 domain
      cl21498
      Location:147191
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    4. XM_011509748.3XP_011508050.1  REST corepressor 3 isoform X2

      Conserved Domains (4) summary
      COG5259
      Location:223356
      RSC8; RSC chromatin remodeling complex subunit RSC8 [Chromatin structure and dynamics / Transcription]
      pfam00249
      Location:322365
      Myb_DNA-binding; Myb-like DNA-binding domain
      pfam01448
      Location:60111
      ELM2; ELM2 domain
      cl21498
      Location:147191
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    5. XM_047425021.1XP_047280977.1  REST corepressor 3 isoform X6

    6. XM_017001761.3XP_016857250.1  REST corepressor 3 isoform X3

    7. XM_047425032.1XP_047280988.1  REST corepressor 3 isoform X7

    8. XM_047425043.1XP_047280999.1  REST corepressor 3 isoform X9

      UniProtKB/TrEMBL
      B4DV59
    9. XM_047425052.1XP_047281008.1  REST corepressor 3 isoform X11

      UniProtKB/TrEMBL
      B4DV59
    10. XM_047425053.1XP_047281009.1  REST corepressor 3 isoform X12

      UniProtKB/TrEMBL
      B4DV59
      Related
      ENSP00000432779.1, ENST00000528926.5
    11. XM_047425038.1XP_047280994.1  REST corepressor 3 isoform X8

      UniProtKB/TrEMBL
      B4DV59
    12. XM_047425051.1XP_047281007.1  REST corepressor 3 isoform X10

    13. XM_047425011.1XP_047280967.1  REST corepressor 3 isoform X5

    RNA

    1. XR_007061956.1 RNA Sequence

    2. XR_007061955.1 RNA Sequence

    3. XR_007061958.1 RNA Sequence

    4. XR_007061957.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      210504931..210561986
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054337627.1XP_054193602.1  REST corepressor 3 isoform X9

      UniProtKB/TrEMBL
      B4DV59
    2. XM_054337618.1XP_054193593.1  REST corepressor 3 isoform X1

    3. XM_054337621.1XP_054193596.1  REST corepressor 3 isoform X4

    4. XM_054337619.1XP_054193594.1  REST corepressor 3 isoform X2

    5. XM_054337623.1XP_054193598.1  REST corepressor 3 isoform X6

    6. XM_054337620.1XP_054193595.1  REST corepressor 3 isoform X3

    7. XM_054337624.1XP_054193599.1  REST corepressor 3 isoform X7

    8. XM_054337626.1XP_054193601.1  REST corepressor 3 isoform X9

      UniProtKB/TrEMBL
      B4DV59
    9. XM_054337629.1XP_054193604.1  REST corepressor 3 isoform X11

      UniProtKB/TrEMBL
      B4DV59
    10. XM_054337630.1XP_054193605.1  REST corepressor 3 isoform X12

      UniProtKB/TrEMBL
      B4DV59
    11. XM_054337625.1XP_054193600.1  REST corepressor 3 isoform X8

      UniProtKB/TrEMBL
      B4DV59
    12. XM_054337628.1XP_054193603.1  REST corepressor 3 isoform X10

    13. XM_054337622.1XP_054193597.1  REST corepressor 3 isoform X5

    RNA

    1. XR_008486105.1 RNA Sequence

    2. XR_008486104.1 RNA Sequence

    3. XR_008486107.1 RNA Sequence

    4. XR_008486106.1 RNA Sequence