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    UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 [ Homo sapiens (human) ]

    Gene ID: 55757, updated on 17-Jun-2019

    Summary

    Official Symbol
    UGGT2provided by HGNC
    Official Full Name
    UDP-glucose glycoprotein glucosyltransferase 2provided by HGNC
    Primary source
    HGNC:HGNC:15664
    See related
    Ensembl:ENSG00000102595 MIM:605898
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    UGT2; HUGT2; UGCGL2
    Summary
    UDP-glucose:glycoprotein glucosyltransferase (UGT) is a soluble protein of the endoplasmic reticulum (ER) that selectively reglucosylates unfolded glycoproteins, thus providing quality control for protein transport out of the ER.[supplied by OMIM, Oct 2009]
    Expression
    Ubiquitous expression in thyroid (RPKM 5.5), testis (RPKM 4.6) and 25 other tissues See more
    Orthologs

    Genomic context

    See UGGT2 in Genome Data Viewer
    Location:
    13q32.1
    Exon count:
    46
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 13 NC_000013.11 (95801580..96053437, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (96453834..96705736, complement)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene DnaJ heat shock protein family (Hsp40) member C3 Neighboring gene MT-CYB pseudogene 3 Neighboring gene uncharacterized LOC105370322 Neighboring gene high mobility group nucleosome binding domain 1 pseudogene 24 Neighboring gene heparan sulfate 6-O-sulfotransferase 3 Neighboring gene RNA, 7SL, cytoplasmic 164, pseudogene Neighboring gene microRNA 4501

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Asparagine N-linked glycosylation, organism-specific biosystem (from REACTOME)
      Asparagine N-linked glycosylation, organism-specific biosystemN-linked glycosylation is the most important form of post-translational modification for proteins synthesized and folded in the Endoplasmic Reticulum (Stanley et al. 2009). An early study in 1999 rev...
    • Calnexin/calreticulin cycle, organism-specific biosystem (from REACTOME)
      Calnexin/calreticulin cycle, organism-specific biosystemThe unfolded protein is recognized by a chaperon protein (calnexin or calreticulin) and the folding process starts. The binding of these protein requires a mono-glucosylated glycan (Caramelo JJ and P...
    • ER Quality Control Compartment (ERQC), organism-specific biosystem (from REACTOME)
      ER Quality Control Compartment (ERQC), organism-specific biosystemProteins that are released from the CNX or CRT complex with folding defects accumulate in a compartment of the ER called ERQC (Kamhi-Nesher et al. 2001). Here, the enzymes UGGG1 or UGGG2 are able to ...
    • Metabolism of proteins, organism-specific biosystem (from REACTOME)
      Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
    • N-glycan trimming in the ER and Calnexin/Calreticulin cycle, organism-specific biosystem (from REACTOME)
      N-glycan trimming in the ER and Calnexin/Calreticulin cycle, organism-specific biosystemAfter being synthesized in the ER membrane the 14-sugars lipid-linked oligosaccharide is co-translationally transferred to an unfolded protein, as described in the previous steps. After this point th...
    • Post-translational protein modification, organism-specific biosystem (from REACTOME)
      Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...
    • Protein processing in endoplasmic reticulum, organism-specific biosystem (from KEGG)
      Protein processing in endoplasmic reticulum, organism-specific biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
    • Protein processing in endoplasmic reticulum, conserved biosystem (from KEGG)
      Protein processing in endoplasmic reticulum, conserved biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ10873, FLJ11485, MGC87276, MGC117360, MGC150689

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    UDP-glucose:glycoprotein glucosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    UDP-glucose:glycoprotein glucosyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    ER-associated misfolded protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    UDP-glucosylation IEA
    Inferred from Electronic Annotation
    more info
     
    endoplasmic reticulum mannose trimming TAS
    Traceable Author Statement
    more info
     
    protein N-linked glycosylation via asparagine IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    endoplasmic reticulum lumen ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    endoplasmic reticulum lumen TAS
    Traceable Author Statement
    more info
     
    endoplasmic reticulum quality control compartment IEA
    Inferred from Electronic Annotation
    more info
     
    endoplasmic reticulum-Golgi intermediate compartment IEA
    Inferred from Electronic Annotation
    more info
     
    protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    UDP-glucose:glycoprotein glucosyltransferase 2
    Names
    UDP-Glc:glycoprotein glucosyltransferase 2
    UDP-glucose ceramide glucosyltransferase-like 1
    UDP-glucose ceramide glucosyltransferase-like 2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020121.4NP_064506.3  UDP-glucose:glycoprotein glucosyltransferase 2 precursor

      See identical proteins and their annotated locations for NP_064506.3

      Status: VALIDATED

      Source sequence(s)
      AF227906, AL162500, BC017759, BC032302
      Consensus CDS
      CCDS9480.1
      UniProtKB/Swiss-Prot
      Q9NYU1
      UniProtKB/TrEMBL
      Q05D90
      Related
      ENSP00000365938.3, ENST00000376747.8
      Conserved Domains (2) summary
      cd06432
      Location:12311478
      GT8_HUGT1_C_like; The C-terminal domain of HUGT1-like is highly homologous to the GT 8 family
      pfam06427
      Location:331189
      UDP-g_GGTase; UDP-glucose:Glycoprotein Glucosyltransferase

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p13 Primary Assembly

      Range
      95801580..96053437 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011521097.1XP_011519399.1  UDP-glucose:glycoprotein glucosyltransferase 2 isoform X4

      Conserved Domains (2) summary
      cd06432
      Location:12581505
      GT8_HUGT1_C_like; The C-terminal domain of HUGT1-like is highly homologous to the GT 8 family
      pfam06427
      Location:331216
      UDP-g_GGTase; UDP-glucose:Glycoprotein Glucosyltransferase
    2. XM_017020662.1XP_016876151.1  UDP-glucose:glycoprotein glucosyltransferase 2 isoform X5

    3. XM_011521096.1XP_011519398.1  UDP-glucose:glycoprotein glucosyltransferase 2 isoform X3

      Conserved Domains (2) summary
      cd06432
      Location:12141461
      GT8_HUGT1_C_like; The C-terminal domain of HUGT1-like is highly homologous to the GT 8 family
      pfam06427
      Location:331172
      UDP-g_GGTase; UDP-glucose:Glycoprotein Glucosyltransferase
    4. XM_011521095.1XP_011519397.1  UDP-glucose:glycoprotein glucosyltransferase 2 isoform X2

      Conserved Domains (2) summary
      cd06432
      Location:12311478
      GT8_HUGT1_C_like; The C-terminal domain of HUGT1-like is highly homologous to the GT 8 family
      pfam06427
      Location:331189
      UDP-g_GGTase; UDP-glucose:Glycoprotein Glucosyltransferase
    5. XM_011521094.1XP_011519396.1  UDP-glucose:glycoprotein glucosyltransferase 2 isoform X1

      Conserved Domains (2) summary
      cd06432
      Location:12581505
      GT8_HUGT1_C_like; The C-terminal domain of HUGT1-like is highly homologous to the GT 8 family
      pfam06427
      Location:331216
      UDP-g_GGTase; UDP-glucose:Glycoprotein Glucosyltransferase
    6. XM_024449384.1XP_024305152.1  UDP-glucose:glycoprotein glucosyltransferase 2 isoform X6

      Conserved Domains (2) summary
      cd06432
      Location:9381185
      GT8_HUGT1_C_like; The C-terminal domain of HUGT1-like is highly homologous to the GT 8 family
      pfam06427
      Location:1896
      UDP-g_GGTase; UDP-glucose:Glycoprotein Glucosyltransferase
    7. XM_017020663.1XP_016876152.1  UDP-glucose:glycoprotein glucosyltransferase 2 isoform X12

    8. XM_024449385.1XP_024305153.1  UDP-glucose:glycoprotein glucosyltransferase 2 isoform X7

      Conserved Domains (2) summary
      cd06432
      Location:9311178
      GT8_HUGT1_C_like; The C-terminal domain of HUGT1-like is highly homologous to the GT 8 family
      pfam06427
      Location:3889
      UDP-g_GGTase; UDP-glucose:Glycoprotein Glucosyltransferase
    9. XM_011521099.2XP_011519401.1  UDP-glucose:glycoprotein glucosyltransferase 2 isoform X8

      Conserved Domains (2) summary
      cd06432
      Location:9041151
      GT8_HUGT1_C_like; The C-terminal domain of HUGT1-like is highly homologous to the GT 8 family
      pfam06427
      Location:1862
      UDP-g_GGTase; UDP-glucose:Glycoprotein Glucosyltransferase
    10. XM_011521103.2XP_011519405.1  UDP-glucose:glycoprotein glucosyltransferase 2 isoform X11

      Conserved Domains (2) summary
      cd06432
      Location:586833
      GT8_HUGT1_C_like; The C-terminal domain of HUGT1-like is highly homologous to the GT 8 family
      pfam06427
      Location:1544
      UDP-g_GGTase; UDP-glucose:Glycoprotein Glucosyltransferase
    11. XM_011521102.2XP_011519404.1  UDP-glucose:glycoprotein glucosyltransferase 2 isoform X10

      Conserved Domains (2) summary
      cd06432
      Location:699946
      GT8_HUGT1_C_like; The C-terminal domain of HUGT1-like is highly homologous to the GT 8 family
      pfam06427
      Location:1657
      UDP-g_GGTase; UDP-glucose:Glycoprotein Glucosyltransferase
    12. XM_011521100.2XP_011519402.1  UDP-glucose:glycoprotein glucosyltransferase 2 isoform X9

      Conserved Domains (1) summary
      pfam06427
      Location:331013
      UDP-g_GGTase; UDP-glucose:Glycoprotein Glucosyltransferase

    RNA

    1. XR_001749630.1 RNA Sequence

    2. XR_931617.1 RNA Sequence

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