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    PRKAR1B protein kinase cAMP-dependent type I regulatory subunit beta [ Homo sapiens (human) ]

    Gene ID: 5575, updated on 6-Jun-2024

    Summary

    Official Symbol
    PRKAR1Bprovided by HGNC
    Official Full Name
    protein kinase cAMP-dependent type I regulatory subunit betaprovided by HGNC
    Primary source
    HGNC:HGNC:9390
    See related
    Ensembl:ENSG00000188191 MIM:176911; AllianceGenome:HGNC:9390
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MASNS; PRKAR1
    Summary
    The protein encoded by this gene is a regulatory subunit of cyclic AMP-dependent protein kinase A (PKA), which is involved in the signaling pathway of the second messenger cAMP. Two regulatory and two catalytic subunits form the PKA holoenzyme, disbands after cAMP binding. The holoenzyme is involved in many cellular events, including ion transport, metabolism, and transcription. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Aug 2015]
    Expression
    Biased expression in brain (RPKM 53.5), ovary (RPKM 6.9) and 11 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See PRKAR1B in Genome Data Viewer
    Location:
    7p22.3
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (549197..728934, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (650161..832029, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (588834..767313, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124901566 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25469 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25470 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:499317-500044 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:500045-500772 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:510601-511557 Neighboring gene Sharpr-MPRA regulatory region 3057 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:515046-515940 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:519557-520077 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:530277-531056 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:531057-531836 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:535084-536005 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:536006-536926 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:543335-544112 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:549933-550440 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:550441-550948 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:551965-552472 Neighboring gene Sharpr-MPRA regulatory region 8552 Neighboring gene NANOG hESC enhancer GRCh37_chr7:555259-555760 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:556430-557352 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:558275-559196 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17808 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17809 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:561041-561962 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17812 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:570324-570520 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:572659-573216 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:578299-579242 Neighboring gene platelet derived growth factor subunit A Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:579243-580184 Neighboring gene PDGFA divergent transcript Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:592082-592582 Neighboring gene PRKAR1B antisense RNA 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:611753-612521 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:612522-613291 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:630646-630792 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17813 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17814 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25471 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:643285-643970 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25473 Neighboring gene PRKAR1B antisense RNA 1 Neighboring gene uncharacterized LOC105375119 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:653082-653582 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:653583-654083 Neighboring gene MPRA-validated peak6334 silencer Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr7:690976-692175 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:715563-715737 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:736050-736550 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:736551-737051 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17815 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17816 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17817 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17818 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17819 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:770503-771002 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr7:791462-792661 Neighboring gene dynein axonemal assembly factor 5 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr7:807142-808341 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr7:821444-822643 Neighboring gene uncharacterized LOC124901567 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:837226-837726 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:849762-850262 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:850239-850399 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:852706-853270 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:853271-853834 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:855273-856014 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17820 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17821 Neighboring gene Sharpr-MPRA regulatory region 7003 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:869831-870726 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25474 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr7:871666-872865 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25475 Neighboring gene Sad1 and UNC84 domain containing 1 Neighboring gene uncharacterized LOC124901568

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Nef nef Serine residues Ser6 and Ser9 of HIV-1 Nef are phosphorylated by PKA in a cell-free system; intracellularly, only Ser9 of HIV-1 NL4-3 Nef is phosphorylated by PKA in resting peripheral blood mononuclear cells PubMed
    Tat tat HIV-1 Tat induces IL-6 and TNF-alpha expression through the activation of cAMP-dependent protein kinase pathways PubMed
    Vif vif Protein kinase A (PKA) binds and phosphorylates A3G at Thr32 in vitro and in vivo. This phosphorylation event reduces the binding of A3G to Vif and its subsequent ubiquitination and degradation PubMed
    Vpr vpr HIV-1 Vpr directly interacts with PKA and is phosphorylated at position Ser79 by PKA. PKA activity is necessary for virion-delivered Vpr cell cycle arrest PubMed
    matrix gag HIV-1 MA increases phosphorylation and the DNA-binding activity of CREB and c-Myc through activation of the cAMP/PKA and MEK/ERK signaling pathways. Both signaling pathways are synergistically activated upon co-stimulation through the CD19 receptor PubMed
    gag Protein kinase A (PKA) has been shown to phosphorylate HIV-1 Matrix in vitro PubMed
    gag HIV-1 Matrix impairs proliferation of normal lymphocytes in vitro by inducing the activity of the inhibitory protein kinase A (PKA) PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cAMP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cAMP-dependent protein kinase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cAMP-dependent protein kinase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables cAMP-dependent protein kinase regulator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables cAMP-dependent protein kinase regulator activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase A catalytic subunit binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein kinase A catalytic subunit binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Schaffer collateral - CA1 synapse IEA
    Inferred from Electronic Annotation
    more info
     
    part_of cAMP-dependent protein kinase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of cAMP-dependent protein kinase complex NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in ciliary base TAS
    Traceable Author Statement
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    located_in hippocampal mossy fiber to CA3 synapse IEA
    Inferred from Electronic Annotation
    more info
     
    located_in multivesicular body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in postsynapse IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    cAMP-dependent protein kinase type I-beta regulatory subunit
    Names
    protein kinase, cAMP-dependent, regulatory subunit type I beta
    protein kinase, cAMP-dependent, regulatory, type I, beta
    NP_001158230.1
    NP_001158231.1
    NP_001158232.1
    NP_001158233.1
    NP_001158234.1
    NP_002726.1
    XP_011513748.1
    XP_047276563.1
    XP_047276564.1
    XP_047276565.1
    XP_047276566.1
    XP_054214610.1
    XP_054214611.1
    XP_054214612.1
    XP_054214613.1
    XP_054214614.1
    XP_054214615.1
    XP_054214616.1
    XP_054214617.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_042811.1 RefSeqGene

      Range
      5396..183479
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001164758.2NP_001158230.1  cAMP-dependent protein kinase type I-beta regulatory subunit

      See identical proteins and their annotated locations for NP_001158230.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All of the variants encode the same protein.
      Source sequence(s)
      AC147651, BC036828, DA910871
      Consensus CDS
      CCDS34579.1
      UniProtKB/Swiss-Prot
      P31321, Q8N422
      UniProtKB/TrEMBL
      A8K099, B4DM81
      Related
      ENSP00000385349.1, ENST00000403562.5
      Conserved Domains (2) summary
      cd12102
      Location:1164
      DD_RIbeta_PKA; Dimerization/Docking domain of the Type I beta Regulatory subunit of cAMP-dependent protein kinase
      cd00038
      Location:255370
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    2. NM_001164759.1NP_001158231.1  cAMP-dependent protein kinase type I-beta regulatory subunit

      See identical proteins and their annotated locations for NP_001158231.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All of the variants encode the same protein.
      Source sequence(s)
      AC147651, BC036828, DA210679
      Consensus CDS
      CCDS34579.1
      UniProtKB/Swiss-Prot
      P31321, Q8N422
      UniProtKB/TrEMBL
      A8K099, B4DM81
      Conserved Domains (2) summary
      cd12102
      Location:1164
      DD_RIbeta_PKA; Dimerization/Docking domain of the Type I beta Regulatory subunit of cAMP-dependent protein kinase
      cd00038
      Location:255370
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    3. NM_001164760.2NP_001158232.1  cAMP-dependent protein kinase type I-beta regulatory subunit

      See identical proteins and their annotated locations for NP_001158232.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. All of the variants encode the same protein.
      Source sequence(s)
      AC147651, BC036828, CT003793
      Consensus CDS
      CCDS34579.1
      UniProtKB/Swiss-Prot
      P31321, Q8N422
      UniProtKB/TrEMBL
      A8K099, B4DM81
      Related
      ENSP00000440449.1, ENST00000537384.6
      Conserved Domains (2) summary
      cd12102
      Location:1164
      DD_RIbeta_PKA; Dimerization/Docking domain of the Type I beta Regulatory subunit of cAMP-dependent protein kinase
      cd00038
      Location:255370
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    4. NM_001164761.2NP_001158233.1  cAMP-dependent protein kinase type I-beta regulatory subunit

      See identical proteins and their annotated locations for NP_001158233.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. All of the variants encode the same protein.
      Source sequence(s)
      AC147651, BC036828, DA162030
      Consensus CDS
      CCDS34579.1
      UniProtKB/Swiss-Prot
      P31321, Q8N422
      UniProtKB/TrEMBL
      A8K099, B4DM81
      Related
      ENSP00000385749.1, ENST00000406797.5
      Conserved Domains (2) summary
      cd12102
      Location:1164
      DD_RIbeta_PKA; Dimerization/Docking domain of the Type I beta Regulatory subunit of cAMP-dependent protein kinase
      cd00038
      Location:255370
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    5. NM_001164762.2NP_001158234.1  cAMP-dependent protein kinase type I-beta regulatory subunit

      See identical proteins and their annotated locations for NP_001158234.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. All of the variants encode the same protein.
      Source sequence(s)
      AC147651, BC036828, DA501689
      Consensus CDS
      CCDS34579.1
      UniProtKB/Swiss-Prot
      P31321, Q8N422
      UniProtKB/TrEMBL
      A8K099, B4DM81
      Related
      ENSP00000444487.1, ENST00000544935.5
      Conserved Domains (2) summary
      cd12102
      Location:1164
      DD_RIbeta_PKA; Dimerization/Docking domain of the Type I beta Regulatory subunit of cAMP-dependent protein kinase
      cd00038
      Location:255370
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    6. NM_002735.3NP_002726.1  cAMP-dependent protein kinase type I-beta regulatory subunit

      See identical proteins and their annotated locations for NP_002726.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All of the variants encode the same protein.
      Source sequence(s)
      AC147651, BC036828, DC314672
      Consensus CDS
      CCDS34579.1
      UniProtKB/Swiss-Prot
      P31321, Q8N422
      UniProtKB/TrEMBL
      A8K099, B4DM81
      Related
      ENSP00000353415.4, ENST00000360274.8
      Conserved Domains (2) summary
      cd12102
      Location:1164
      DD_RIbeta_PKA; Dimerization/Docking domain of the Type I beta Regulatory subunit of cAMP-dependent protein kinase
      cd00038
      Location:255370
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      549197..728934 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047420607.1XP_047276563.1  cAMP-dependent protein kinase type I-beta regulatory subunit isoform X1

      UniProtKB/Swiss-Prot
      P31321, Q8N422
      UniProtKB/TrEMBL
      A8K099, B4DM81
    2. XM_047420608.1XP_047276564.1  cAMP-dependent protein kinase type I-beta regulatory subunit isoform X1

      UniProtKB/Swiss-Prot
      P31321, Q8N422
      UniProtKB/TrEMBL
      A8K099, B4DM81
    3. XM_011515446.3XP_011513748.1  cAMP-dependent protein kinase type I-beta regulatory subunit isoform X2

      UniProtKB/TrEMBL
      A8K099, B4DM81
      Conserved Domains (2) summary
      COG0664
      Location:194304
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      cd00038
      Location:200315
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    4. XM_047420609.1XP_047276565.1  cAMP-dependent protein kinase type I-beta regulatory subunit isoform X3

      UniProtKB/TrEMBL
      H7BYW5
    5. XM_047420610.1XP_047276566.1  cAMP-dependent protein kinase type I-beta regulatory subunit isoform X3

      UniProtKB/TrEMBL
      H7BYW5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      650161..832029 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054358635.1XP_054214610.1  cAMP-dependent protein kinase type I-beta regulatory subunit isoform X1

      UniProtKB/Swiss-Prot
      P31321, Q8N422
      UniProtKB/TrEMBL
      A8K099, B4DM81
    2. XM_054358636.1XP_054214611.1  cAMP-dependent protein kinase type I-beta regulatory subunit isoform X1

      UniProtKB/Swiss-Prot
      P31321, Q8N422
      UniProtKB/TrEMBL
      A8K099, B4DM81
    3. XM_054358637.1XP_054214612.1  cAMP-dependent protein kinase type I-beta regulatory subunit isoform X2

      UniProtKB/TrEMBL
      A8K099, B4DM81
    4. XM_054358641.1XP_054214616.1  cAMP-dependent protein kinase type I-beta regulatory subunit isoform X3

      UniProtKB/TrEMBL
      H7BYW5
    5. XM_054358642.1XP_054214617.1  cAMP-dependent protein kinase type I-beta regulatory subunit isoform X3

      UniProtKB/TrEMBL
      H7BYW5
    6. XM_054358639.1XP_054214614.1  cAMP-dependent protein kinase type I-beta regulatory subunit isoform X4

      UniProtKB/TrEMBL
      C9JSK5
    7. XM_054358638.1XP_054214613.1  cAMP-dependent protein kinase type I-beta regulatory subunit isoform X4

      UniProtKB/TrEMBL
      C9JSK5
    8. XM_054358640.1XP_054214615.1  cAMP-dependent protein kinase type I-beta regulatory subunit isoform X4

      UniProtKB/TrEMBL
      C9JSK5