Format

Send to:

Choose Destination
    • Showing Current items.

    FAM222B family with sequence similarity 222 member B [ Homo sapiens (human) ]

    Gene ID: 55731, updated on 17-Jun-2019

    Summary

    Official Symbol
    FAM222Bprovided by HGNC
    Official Full Name
    family with sequence similarity 222 member Bprovided by HGNC
    Primary source
    HGNC:HGNC:25563
    See related
    Ensembl:ENSG00000173065
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C17orf63
    Expression
    Broad expression in testis (RPKM 12.8), duodenum (RPKM 3.8) and 24 other tissues See more
    Orthologs

    Genomic context

    See FAM222B in Genome Data Viewer
    Location:
    17q11.2
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (28755979..28854985, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (27082996..27169857, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 11843 Neighboring gene NIMA related kinase 8 Neighboring gene TNF receptor associated factor 4 Neighboring gene ribosomal protein L31 pseudogene 58 Neighboring gene Era like 12S mitochondrial rRNA chaperone 1 Neighboring gene microRNA 451a Neighboring gene microRNA 451b Neighboring gene microRNA 144

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ10700

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    protein FAM222B
    Names
    uncharacterized protein C17orf63

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077498.3NP_001070966.1  protein FAM222B isoform 2

      See identical proteins and their annotated locations for NP_001070966.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR, lacks an exon in the 5' coding region and initiates translation at an alternate start codon, compared to variant 3. Variants 1, 2, 4, 5, 6, and 7 encode the same isoform (2), which is shorter and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AC010761, AK057665, BC021228
      Consensus CDS
      CCDS45637.1
      UniProtKB/Swiss-Prot
      Q8WU58
      UniProtKB/TrEMBL
      A0A024QZ60, B3KQ88
      Related
      ENSP00000462419.1, ENST00000581407.5
      Conserved Domains (1) summary
      pfam15258
      Location:27561
      FAM222A; Protein family of FAM222A
    2. NM_001288631.2NP_001275560.1  protein FAM222B isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC010761, BC021228, DA789853
      UniProtKB/Swiss-Prot
      Q8WU58
      Conserved Domains (2) summary
      pfam14650
      Location:163214
      FAM75; FAM75 family
      pfam15258
      Location:31564
      FAM222A; Protein family of FAM222A
    3. NM_001288632.2NP_001275561.1  protein FAM222B isoform 2

      See identical proteins and their annotated locations for NP_001275561.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, lacks an exon in the 5' coding region and initiates translation at an alternate start codon, compared to variant 3. Variants 1, 2, 4, 5, 6, and 7 encode the same isoform (2), which is shorter and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AC010761, BC021228, DB453514, HY040104
      Consensus CDS
      CCDS45637.1
      UniProtKB/Swiss-Prot
      Q8WU58
      UniProtKB/TrEMBL
      A0A024QZ60
      Conserved Domains (1) summary
      pfam15258
      Location:27561
      FAM222A; Protein family of FAM222A
    4. NM_001288633.2NP_001275562.1  protein FAM222B isoform 2

      See identical proteins and their annotated locations for NP_001275562.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, lacks an exon in the 5' coding region and initiates translation at an alternate start codon, compared to variant 3. Variants 1, 2, 4, 5, 6, and 7 encode the same isoform (2), which is shorter and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AC010761, BC021228, HY012898
      Consensus CDS
      CCDS45637.1
      UniProtKB/Swiss-Prot
      Q8WU58
      UniProtKB/TrEMBL
      A0A024QZ60
      Conserved Domains (1) summary
      pfam15258
      Location:27561
      FAM222A; Protein family of FAM222A
    5. NM_001288634.2NP_001275563.1  protein FAM222B isoform 2

      See identical proteins and their annotated locations for NP_001275563.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) includes an alternate 5' terminal exon, lacks an exon in the 5' coding region and initiates translation at an alternate start codon, compared to variant 3. Variants 1, 2, 4, 5, 6, and 7 encode the same isoform (2), which is shorter and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AC010761, AK095569, BC021228
      Consensus CDS
      CCDS45637.1
      UniProtKB/Swiss-Prot
      Q8WU58
      UniProtKB/TrEMBL
      A0A024QZ60, B3KTH5
      Related
      ENSP00000413645.3, ENST00000452648.7
      Conserved Domains (1) summary
      pfam15258
      Location:27561
      FAM222A; Protein family of FAM222A
    6. NM_001288635.2NP_001275564.1  protein FAM222B isoform 2

      See identical proteins and their annotated locations for NP_001275564.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR, lacks an exon in the 5' coding region and initiates translation at an alternate start codon, compared to variant 3. Variants 1, 2, 4, 5, 6, and 7 encode the same isoform (2), which is shorter and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AC010761, BC021228, DC381712, HY040104
      Consensus CDS
      CCDS45637.1
      UniProtKB/Swiss-Prot
      Q8WU58
      UniProtKB/TrEMBL
      A0A024QZ60
      Conserved Domains (1) summary
      pfam15258
      Location:27561
      FAM222A; Protein family of FAM222A
    7. NM_001288636.2NP_001275565.1  protein FAM222B isoform 3

      See identical proteins and their annotated locations for NP_001275565.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 3. Variants 8 through 12 encode the same isoform (3), which is shorter at the N-terminus, compared to isoform 1.
      Source sequence(s)
      AC010761, BC021228, HY006495
      Consensus CDS
      CCDS74022.1
      UniProtKB/Swiss-Prot
      Q8WU58
      UniProtKB/TrEMBL
      B4DRX9
      Conserved Domains (1) summary
      pfam15258
      Location:1433
      FAM222A; Protein family of FAM222A
    8. NM_001288637.2NP_001275566.1  protein FAM222B isoform 3

      See identical proteins and their annotated locations for NP_001275566.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 3. Variants 8 through 12 encode the same isoform (3), which is shorter at the N-terminus, compared to isoform 1.
      Source sequence(s)
      AC010761, BC021228, DA887444
      Consensus CDS
      CCDS74022.1
      UniProtKB/Swiss-Prot
      Q8WU58
      UniProtKB/TrEMBL
      B4DRX9
      Related
      ENSP00000343115.6, ENST00000341217.6
      Conserved Domains (1) summary
      pfam15258
      Location:1433
      FAM222A; Protein family of FAM222A
    9. NM_001288638.2NP_001275567.1  protein FAM222B isoform 3

      See identical proteins and their annotated locations for NP_001275567.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (10) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 3. Variants 8 through 12 encode the same isoform (3), which is shorter at the N-terminus, compared to isoform 1.
      Source sequence(s)
      AC010761, BC021228, DC400943, HY040104
      Consensus CDS
      CCDS74022.1
      UniProtKB/Swiss-Prot
      Q8WU58
      UniProtKB/TrEMBL
      B4DRX9
      Conserved Domains (1) summary
      pfam15258
      Location:1433
      FAM222A; Protein family of FAM222A
    10. NM_001288639.2NP_001275568.1  protein FAM222B isoform 3

      See identical proteins and their annotated locations for NP_001275568.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (11) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 3. Variants 8 through 12 encode the same isoform (3), which is shorter at the N-terminus, compared to isoform 1.
      Source sequence(s)
      AC010761, BC021228, DC376581, HY040104
      Consensus CDS
      CCDS74022.1
      UniProtKB/Swiss-Prot
      Q8WU58
      UniProtKB/TrEMBL
      B4DRX9
      Conserved Domains (1) summary
      pfam15258
      Location:1433
      FAM222A; Protein family of FAM222A
    11. NM_001288640.2NP_001275569.1  protein FAM222B isoform 3

      See identical proteins and their annotated locations for NP_001275569.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (12) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 3. Variants 8 through 12 encode the same isoform (3), which is shorter at the N-terminus, compared to isoform 1.
      Source sequence(s)
      AC010761, AK299477, BC021228, HY040104
      Consensus CDS
      CCDS74022.1
      UniProtKB/Swiss-Prot
      Q8WU58
      UniProtKB/TrEMBL
      B4DRX9
      Conserved Domains (1) summary
      pfam15258
      Location:1433
      FAM222A; Protein family of FAM222A
    12. NM_018182.4NP_060652.2  protein FAM222B isoform 2

      See identical proteins and their annotated locations for NP_060652.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks an exon in the 5' coding region and initiates translation at an alternate start codon, compared to variant 3. Variants 1, 2, 4, 5, 6, and 7 encode the same isoform (2), which is shorter and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AC010761, BC021228, DC374179, HY040104
      Consensus CDS
      CCDS45637.1
      UniProtKB/Swiss-Prot
      Q8WU58
      UniProtKB/TrEMBL
      A0A024QZ60
      Conserved Domains (1) summary
      pfam15258
      Location:27561
      FAM222A; Protein family of FAM222A

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

      Range
      28755979..28854985 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011524987.1XP_011523289.1  protein FAM222B isoform X1

      See identical proteins and their annotated locations for XP_011523289.1

      UniProtKB/TrEMBL
      B4DRX9
      Conserved Domains (1) summary
      pfam15258
      Location:1433
      FAM222A; Protein family of FAM222A
    2. XM_011524986.2XP_011523288.1  protein FAM222B isoform X1

      See identical proteins and their annotated locations for XP_011523288.1

      UniProtKB/TrEMBL
      B4DRX9
      Conserved Domains (1) summary
      pfam15258
      Location:1433
      FAM222A; Protein family of FAM222A
    3. XM_011524988.2XP_011523290.1  protein FAM222B isoform X1

      See identical proteins and their annotated locations for XP_011523290.1

      UniProtKB/TrEMBL
      B4DRX9
      Conserved Domains (1) summary
      pfam15258
      Location:1433
      FAM222A; Protein family of FAM222A
    4. XM_017024835.2XP_016880324.1  protein FAM222B isoform X1

      UniProtKB/TrEMBL
      B4DRX9
      Conserved Domains (1) summary
      pfam15258
      Location:1433
      FAM222A; Protein family of FAM222A
    Support Center