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    PRKAG1 protein kinase AMP-activated non-catalytic subunit gamma 1 [ Homo sapiens (human) ]

    Gene ID: 5571, updated on 17-Jun-2024

    Summary

    Official Symbol
    PRKAG1provided by HGNC
    Official Full Name
    protein kinase AMP-activated non-catalytic subunit gamma 1provided by HGNC
    Primary source
    HGNC:HGNC:9385
    See related
    Ensembl:ENSG00000181929 MIM:602742; AllianceGenome:HGNC:9385
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AMPKG
    Summary
    The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit is one of the gamma regulatory subunits of AMPK. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in heart (RPKM 18.1), adrenal (RPKM 16.8) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
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    Genomic context

    See PRKAG1 in Genome Data Viewer
    Location:
    12q13.12
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (49002274..49018776, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (48964449..48980948, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (49396057..49412559, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369756 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6300 Neighboring gene Sharpr-MPRA regulatory region 4123 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4419 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4420 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6301 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4421 Neighboring gene Sharpr-MPRA regulatory region 2140 Neighboring gene Sharpr-MPRA regulatory region 4008 Neighboring gene DDN and PRKAG1 antisense RNA 1 Neighboring gene dendrin Neighboring gene Sharpr-MPRA regulatory region 4712 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:49411600-49412190 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6302 Neighboring gene lysine methyltransferase 2D Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr12:49442744-49443943 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:49443977-49444477 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4422 Neighboring gene Sharpr-MPRA regulatory region 5975 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4423 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6303 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6304 Neighboring gene RHEB like 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat Knockdown of SIRT1 by its inhibitor or siRNA results in Tat-mediated reduction of phosphorylation of AMP-activated protein kinase (AMPK) and downstream acetyl-CoA carboxylase (ACC) PubMed
    tat HIV-1 Tat induces IL-6 and TNF-alpha expression through the activation of cAMP-dependent protein kinase pathways PubMed
    Vif vif Protein kinase A (PKA) binds and phosphorylates A3G at Thr32 in vitro and in vivo. This phosphorylation event reduces the binding of A3G to Vif and its subsequent ubiquitination and degradation PubMed
    Vpr vpr HIV-1 Vpr directly interacts with PKA and is phosphorylated at position Ser79 by PKA. PKA activity is necessary for virion-delivered Vpr cell cycle arrest PubMed
    matrix gag HIV-1 MA increases phosphorylation and the DNA-binding activity of CREB and c-Myc through activation of the cAMP/PKA and MEK/ERK signaling pathways. Both signaling pathways are synergistically activated upon co-stimulation through the CD19 receptor PubMed
    gag Protein kinase A (PKA) has been shown to phosphorylate HIV-1 Matrix in vitro PubMed
    gag HIV-1 Matrix impairs proliferation of normal lymphocytes in vitro by inducing the activity of the inhibitory protein kinase A (PKA) PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC8666

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ADP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables AMP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables AMP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables ATP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables cAMP-dependent protein kinase activity TAS
    Traceable Author Statement
    more info
     
    enables cAMP-dependent protein kinase regulator activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein kinase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein kinase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein kinase regulator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein kinase regulator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in membrane HDA PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    part_of nucleotide-activated protein kinase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of nucleotide-activated protein kinase complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    part_of nucleotide-activated protein kinase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    5'-AMP-activated protein kinase subunit gamma-1
    Names
    5'-AMP-activated protein kinase, gamma-1 subunit
    AMPK gamma-1 chain
    AMPK gamma1
    protein kinase, AMP-activated, gamma 1 non-catalytic subunit

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001206709.2NP_001193638.1  5'-AMP-activated protein kinase subunit gamma-1 isoform 3

      See identical proteins and their annotated locations for NP_001193638.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site in the central coding region, compared to variant 1, resulting in an isoform (3) that is longer than isoform 1.
      Source sequence(s)
      AK097606, BC000358, BM667691
      Consensus CDS
      CCDS55825.1
      UniProtKB/Swiss-Prot
      P54619
      Related
      ENSP00000323867.5, ENST00000316299.9
      Conserved Domains (3) summary
      COG0517
      Location:212328
      CBS; CBS domain [Signal transduction mechanisms]
      cd04618
      Location:46184
      CBS_pair_5; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
      cd04641
      Location:211330
      CBS_pair_28; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
    2. NM_001206710.2NP_001193639.1  5'-AMP-activated protein kinase subunit gamma-1 isoform 4

      See identical proteins and their annotated locations for NP_001193639.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (4) is shorter at the N-terminus, compared to isoform 1.
      Source sequence(s)
      AC011603, AK293332, BC000358, BM667691
      Consensus CDS
      CCDS55824.1
      UniProtKB/Swiss-Prot
      P54619
      Related
      ENSP00000448972.1, ENST00000552212.5
      Conserved Domains (2) summary
      cd04618
      Location:6142
      CBS_euAMPK_gamma-like_repeat1; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains found in AMP-activated protein kinase gamma-like proteins, repeat 1
      cd04641
      Location:168291
      CBS_euAMPK_gamma-like_repeat2; CBS pair domain found in 5'-AMP (adenosine monophosphate)-activated protein kinase
    3. NM_002733.5NP_002724.1  5'-AMP-activated protein kinase subunit gamma-1 isoform 1

      See identical proteins and their annotated locations for NP_002724.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      BC000358, BM667691, DB020277
      Consensus CDS
      CCDS8777.1
      UniProtKB/Swiss-Prot
      B4DDT7, P54619, Q8N7V9
      Related
      ENSP00000447433.1, ENST00000548065.7
      Conserved Domains (2) summary
      cd04618
      Location:38174
      CBS_euAMPK_gamma-like_repeat1; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains found in AMP-activated protein kinase gamma-like proteins, repeat 1
      cd04641
      Location:200323
      CBS_euAMPK_gamma-like_repeat2; CBS pair domain found in 5'-AMP (adenosine monophosphate)-activated protein kinase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      49002274..49018776 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011538562.3XP_011536864.1  5'-AMP-activated protein kinase subunit gamma-1 isoform X1

      See identical proteins and their annotated locations for XP_011536864.1

      UniProtKB/Swiss-Prot
      P54619
      Conserved Domains (2) summary
      cd04618
      Location:6142
      CBS_euAMPK_gamma-like_repeat1; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains found in AMP-activated protein kinase gamma-like proteins, repeat 1
      cd04641
      Location:168291
      CBS_euAMPK_gamma-like_repeat2; CBS pair domain found in 5'-AMP (adenosine monophosphate)-activated protein kinase
    2. XM_047429136.1XP_047285092.1  5'-AMP-activated protein kinase subunit gamma-1 isoform X2

      UniProtKB/TrEMBL
      F8VYY9
      Related
      ENSP00000448873.1, ENST00000547306.5
    3. XM_005269020.3XP_005269077.1  5'-AMP-activated protein kinase subunit gamma-1 isoform X3

      Conserved Domains (3) summary
      cd02205
      Location:4690
      CBS_pair_SF; CBS repeat [structural motif]
      cd04641
      Location:116239
      CBS_euAMPK_gamma-like_repeat2; CBS pair domain found in 5'-AMP (adenosine monophosphate)-activated protein kinase
      cl15354
      Location:190
      CBS_pair_SF; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains superfamily

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      48964449..48980948 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054372526.1XP_054228501.1  5'-AMP-activated protein kinase subunit gamma-1 isoform X1

    2. XM_054372527.1XP_054228502.1  5'-AMP-activated protein kinase subunit gamma-1 isoform X3

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_212461.1: Suppressed sequence

      Description
      NM_212461.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.