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    PRKAB2 protein kinase AMP-activated non-catalytic subunit beta 2 [ Homo sapiens (human) ]

    Gene ID: 5565, updated on 21-Dec-2019

    Summary

    Official Symbol
    PRKAB2provided by HGNC
    Official Full Name
    protein kinase AMP-activated non-catalytic subunit beta 2provided by HGNC
    Primary source
    HGNC:HGNC:9379
    See related
    Ensembl:ENSG00000131791 MIM:602741
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. It is highly expressed in skeletal muscle and thus may have tissue-specific roles. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2013]
    Expression
    Ubiquitous expression in duodenum (RPKM 16.7), liver (RPKM 11.0) and 25 other tissues See more
    Orthologs

    Genomic context

    See PRKAB2 in Genome Data Viewer
    Location:
    1q21.1
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109.20191205 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (147155106..147173366, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (146626685..146644168, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene RNA, variant U1 small nuclear 8 Neighboring gene NBPF member 13, pseudogene Neighboring gene protein disulfide isomerase family A member 3 pseudogene 1 Neighboring gene chromodomain helicase DNA binding protein 1 like Neighboring gene flavin containing dimethylaniline monoxygenase 5 Neighboring gene chaperonin containing TCP1 subunit 8 pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat Knockdown of SIRT1 by its inhibitor or siRNA results in Tat-mediated reduction of phosphorylation of AMP-activated protein kinase (AMPK) and downstream acetyl-CoA carboxylase (ACC) PubMed
    Vif vif Protein kinase A (PKA) binds and phosphorylates A3G at Thr32 in vitro and in vivo. This phosphorylation event reduces the binding of A3G to Vif and its subsequent ubiquitination and degradation PubMed
    Vpr vpr HIV-1 Vpr directly interacts with PKA and is phosphorylated at position Ser79 by PKA. PKA activity is necessary for virion-delivered Vpr cell cycle arrest PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC61468

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    contributes_to AMP-activated protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    contributes_to AMP-activated protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    carnitine shuttle TAS
    Traceable Author Statement
    more info
     
    cell cycle arrest TAS
    Traceable Author Statement
    more info
     
    fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    macroautophagy TAS
    Traceable Author Statement
    more info
     
    positive regulation of cold-induced thermogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of fatty acid biosynthetic process TAS
    Traceable Author Statement
    more info
     
    regulation of macroautophagy TAS
    Traceable Author Statement
    more info
     
    regulation of signal transduction by p53 class mediator TAS
    Traceable Author Statement
    more info
     
    signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleotide-activated protein kinase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleotide-activated protein kinase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    5'-AMP-activated protein kinase subunit beta-2
    Names
    5'-AMP-activated protein kinase, beta-2 subunit
    AMP-activated protein kinase beta 2 non-catalytic subunit
    AMPK beta 2
    AMPK beta-2 chain
    AMPK subunit beta-2
    protein kinase, AMP-activated, beta 2 non-catalytic subunit

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_005399.5NP_005390.1  5'-AMP-activated protein kinase subunit beta-2

      See identical proteins and their annotated locations for NP_005390.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes a functional protein.
      Source sequence(s)
      AC241584, BC053610, CA311731
      Consensus CDS
      CCDS925.1
      UniProtKB/Swiss-Prot
      O43741
      Related
      ENSP00000254101.3, ENST00000254101.4
      Conserved Domains (2) summary
      smart01010
      Location:183272
      AMPKBI; 5'-AMP-activated protein kinase beta subunit, interation domain
      pfam16561
      Location:78158
      AMPK1_CBM; Glycogen recognition site of AMP-activated protein kinase

    RNA

    1. NR_103870.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks two internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC241584, AK316183, BC053610, CA311731
    2. NR_103871.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC241584, AK294863, CA311731

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

      Range
      147155106..147173366 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011509729.2XP_011508031.1  5'-AMP-activated protein kinase subunit beta-2 isoform X1

      Conserved Domains (2) summary
      smart01010
      Location:183247
      AMPKBI; 5'-AMP-activated protein kinase beta subunit, interation domain
      pfam16561
      Location:78161
      AMPK1_CBM; Glycogen recognition site of AMP-activated protein kinase
    2. XM_017001697.2XP_016857186.1  5'-AMP-activated protein kinase subunit beta-2 isoform X2

    RNA

    1. XR_001737291.2 RNA Sequence

    2. XR_001737292.2 RNA Sequence

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