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    DEPDC1 DEP domain containing 1 [ Homo sapiens (human) ]

    Gene ID: 55635, updated on 1-Jun-2019

    Summary

    Official Symbol
    DEPDC1provided by HGNC
    Official Full Name
    DEP domain containing 1provided by HGNC
    Primary source
    HGNC:HGNC:22949
    See related
    Ensembl:ENSG00000024526 MIM:612002
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DEP.8; SDP35; DEPDC1A; DEPDC1-V2
    Expression
    Biased expression in testis (RPKM 5.4), lymph node (RPKM 3.0) and 13 other tissues See more
    Orthologs

    Genomic context

    See DEPDC1 in Genome Data Viewer
    Location:
    1p31.3
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (68474152..68497221, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (68939835..68962799, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene elongin C pseudogene 18 Neighboring gene retinoid isomerohydrolase RPE65 Neighboring gene DEPDC1 antisense RNA 1 Neighboring gene thioredoxin pseudogene 2 Neighboring gene uncharacterized LOC107984967

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Clone Names

    • FLJ20354, 5830484J08Rik

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcriptional repressor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transcriptional repressor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    DEP domain-containing protein 1A
    Names
    cell cycle control protein SDP35

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001114120.3NP_001107592.1  DEP domain-containing protein 1A isoform a

      See identical proteins and their annotated locations for NP_001107592.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AB281187, BU588593, DB147703
      Consensus CDS
      CCDS44159.1
      UniProtKB/Swiss-Prot
      Q5TB30
      Related
      ENSP00000412292.2, ENST00000456315.7
      Conserved Domains (3) summary
      cd04405
      Location:181308
      RhoGAP_BRCC3-like; RhoGAP_BRCC3-like: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of BRCC3-like proteins. This subgroup also contains two groups of closely related proteins, BRCC3 and DEPDC7, which both contain a C-terminal RhoGAP-like domain ...
      cl02442
      Location:15106
      DEP; DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is ...
      cl02570
      Location:584690
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
    2. NM_017779.6NP_060249.2  DEP domain-containing protein 1A isoform b

      See identical proteins and their annotated locations for NP_060249.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (b) is shorter, compared to isoform a.
      Source sequence(s)
      AB281274, BU588593, DB147703
      Consensus CDS
      CCDS644.1
      UniProtKB/Swiss-Prot
      Q5TB30
      Related
      ENSP00000360005.5, ENST00000370966.9
      Conserved Domains (2) summary
      cd04405
      Location:181406
      RhoGAP_BRCC3-like; RhoGAP_BRCC3-like: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of BRCC3-like proteins. This subgroup also contains two groups of closely related proteins, BRCC3 and DEPDC7, which both contain a C-terminal RhoGAP-like domain ...
      cl02442
      Location:15106
      DEP; DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

      Range
      68474152..68497221 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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