Format

Send to:

Choose Destination
    • Showing Current items.

    CNOT11 CCR4-NOT transcription complex subunit 11 [ Homo sapiens (human) ]

    Gene ID: 55571, updated on 17-Jun-2019

    Summary

    Official Symbol
    CNOT11provided by HGNC
    Official Full Name
    CCR4-NOT transcription complex subunit 11provided by HGNC
    Primary source
    HGNC:HGNC:25217
    See related
    Ensembl:ENSG00000158435
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C40; C2orf29
    Expression
    Ubiquitous expression in testis (RPKM 19.6), placenta (RPKM 16.9) and 25 other tissues See more
    Orthologs

    Genomic context

    See CNOT11 in Genome Data Viewer
    Location:
    2q11.2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (101252886..101270316)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (101869345..101886778)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene TBC1 domain family member 8 Neighboring gene VISTA enhancer hs1933 Neighboring gene TBC1 domain family member 8 antisense RNA 1 Neighboring gene uncharacterized LOC105373511 Neighboring gene small nucleolar RNA, C/D box 89 Neighboring gene ring finger protein 149 Neighboring gene uncharacterized LOC105373512 Neighboring gene microRNA 5696

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Pathways from BioSystems

    • Deadenylation of mRNA, organism-specific biosystem (from REACTOME)
      Deadenylation of mRNA, organism-specific biosystemDeadenylation of mRNA proceeds in two steps. According to current models, in the first step the poly(A) tail is shortened from about 200 adenosine residues to about 80 residues by the PAN2-PAN3 compl...
    • Deadenylation-dependent mRNA decay, organism-specific biosystem (from REACTOME)
      Deadenylation-dependent mRNA decay, organism-specific biosystemAfter undergoing rounds of translation, mRNA is normally destroyed by the deadenylation-dependent pathway. Though the trigger is unclear, deadenylation likely proceeds in two steps: one catalyzed by...
    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
    • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
      Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...
    • TP53 Regulates Transcription of Cell Cycle Genes, organism-specific biosystem (from REACTOME)
      TP53 Regulates Transcription of Cell Cycle Genes, organism-specific biosystemUnder a variety of stress conditions, TP53 (p53), stabilized by stress-induced phosphorylation at least on S15 and S20 serine residues, can induce the transcription of genes involved in cell cycle ar...
    • TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain, organism-specific biosystem (from REACTOME)
      TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain, organism-specific biosystemBTG2 is induced by TP53, leading to cessation of cellular proliferation (Rouault et al. 1996, Duriez et al. 2002). BTG2 binds to the CCR4-NOT complex and promotes mRNA deadenylation activity of this ...
    • Transcriptional Regulation by TP53, organism-specific biosystem (from REACTOME)
      Transcriptional Regulation by TP53, organism-specific biosystemThe tumor suppressor TP53 (encoded by the gene p53) is a transcription factor. Under stress conditions, it recognizes specific responsive DNA elements and thus regulates the transcription of many gen...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    molecular_function ND
    No biological Data available
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS
    Traceable Author Statement
    more info
     
    cell proliferation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    gene silencing by RNA IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear-transcribed mRNA poly(A) tail shortening TAS
    Traceable Author Statement
    more info
     
    regulation of translation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    CCR4-NOT complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    CCR4-NOT transcription complex subunit 11
    Names
    UPF0760 protein C2orf29

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017546.5NP_060016.3  CCR4-NOT transcription complex subunit 11

      See identical proteins and their annotated locations for NP_060016.3

      Status: VALIDATED

      Source sequence(s)
      BC018664, BM923954, BX394182
      Consensus CDS
      CCDS2050.1
      UniProtKB/Swiss-Prot
      Q9UKZ1
      Related
      ENSP00000289382.3, ENST00000289382.8
      Conserved Domains (1) summary
      pfam10155
      Location:371495
      DUF2363; Uncharacterized conserved protein (DUF2363)

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

      Range
      101252886..101270316
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center