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    NOP10 NOP10 ribonucleoprotein [ Homo sapiens (human) ]

    Gene ID: 55505, updated on 17-Jun-2019

    Summary

    Official Symbol
    NOP10provided by HGNC
    Official Full Name
    NOP10 ribonucleoproteinprovided by HGNC
    Primary source
    HGNC:HGNC:14378
    See related
    Ensembl:ENSG00000182117 MIM:606471
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DKCB1; NOLA3; NOP10P
    Summary
    This gene is a member of the H/ACA snoRNPs (small nucleolar ribonucleoproteins) gene family. snoRNPs are involved in various aspects of rRNA processing and modification and have been classified into two families: C/D and H/ACA. The H/ACA snoRNPs also include the DKC1, NOLA1 and NOLA2 proteins. These four H/ACA snoRNP proteins localize to the dense fibrillar components of nucleoli and to coiled (Cajal) bodies in the nucleus. Both 18S rRNA production and rRNA pseudouridylation are impaired if any one of the four proteins is depleted. The four H/ACA snoRNP proteins are also components of the telomerase complex. This gene encodes a protein related to Saccharomyces cerevisiae Nop10p. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in bone marrow (RPKM 45.9), spleen (RPKM 43.6) and 25 other tissues See more
    Orthologs

    Genomic context

    See NOP10 in Genome Data Viewer
    Location:
    15q14
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (34341716..34343161, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (34633917..34635362, complement)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene katanin regulatory subunit B1 like 1 Neighboring gene solute carrier family 12 member 6 Neighboring gene ER membrane protein complex subunit 4 Neighboring gene NUT midline carcinoma family member 1 Neighboring gene lysophosphatidylcholine acyltransferase 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat Expression of HIV-1 Tat upregulates the abundance of NOP10 ribonucleoprotein (NOP10) in the nucleoli of Jurkat T-cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
    • H/ACA ribonucleoprotein complex, organism-specific biosystem (from KEGG)
      H/ACA ribonucleoprotein complex, organism-specific biosystemStructural complex; Genetic information processing; RNA processing
    • H/ACA ribonucleoprotein complex, conserved biosystem (from KEGG)
      H/ACA ribonucleoprotein complex, conserved biosystemStructural complex; Genetic information processing; RNA processing
    • Ribosome biogenesis in eukaryotes, organism-specific biosystem (from KEGG)
      Ribosome biogenesis in eukaryotes, organism-specific biosystemRibosomes are the cellular factories responsible for making proteins. In eukaryotes, ribosome biogenesis involves the production and correct assembly of four rRNAs and about 80 ribosomal proteins. It...
    • Ribosome biogenesis in eukaryotes, conserved biosystem (from KEGG)
      Ribosome biogenesis in eukaryotes, conserved biosystemRibosomes are the cellular factories responsible for making proteins. In eukaryotes, ribosome biogenesis involves the production and correct assembly of four rRNAs and about 80 ribosomal proteins. It...
    • rRNA modification in the nucleus and cytosol, organism-specific biosystem (from REACTOME)
      rRNA modification in the nucleus and cytosol, organism-specific biosystemHuman ribosomal RNAs (rRNAs) contain about 200 residues that are enzymatically modified after transcription in the nucleolus (Maden and Khan 1977, Maden 1988, Maden and Hughes 1997, reviewed in Herna...
    • rRNA processing, organism-specific biosystem (from REACTOME)
      rRNA processing, organism-specific biosystemEach eukaryotic cytosolic ribosome contains 4 molecules of RNA: 28S rRNA (25S rRNA in yeast), 5.8S rRNA, and 5S rRNA in the 60S subunit and 18S rRNA in the 40S subunit. The 18S rRNA, 5.8S rRNA, and 2...
    • rRNA processing in the nucleus and cytosol, organism-specific biosystem (from REACTOME)
      rRNA processing in the nucleus and cytosol, organism-specific biosystemEach eukaryotic cytosolic ribosome contains 4 molecules of RNA: 28S rRNA (25S rRNA in yeast), 5.8S rRNA, and 5S rRNA in the 60S subunit and 18S rRNA in the 40S subunit. The 18S rRNA, 5.8S rRNA, and 2...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC70651

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    RNA binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    box H/ACA snoRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    box H/ACA snoRNA binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    telomerase RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    telomerase RNA binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    telomerase RNA binding TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    positive regulation of telomerase RNA localization to Cajal body HMP PubMed 
    pseudouridine synthesis NAS
    Non-traceable Author Statement
    more info
    PubMed 
    rRNA pseudouridine synthesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    rRNA pseudouridine synthesis TAS
    Traceable Author Statement
    more info
     
    snRNA pseudouridine synthesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    snoRNA guided rRNA pseudouridine synthesis IEA
    Inferred from Electronic Annotation
    more info
     
    telomere maintenance via telomerase IDA
    Inferred from Direct Assay
    more info
    PubMed 
    telomere maintenance via telomerase TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    box H/ACA scaRNP complex TAS
    Traceable Author Statement
    more info
    PubMed 
    box H/ACA snoRNP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    box H/ACA snoRNP complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    box H/ACA snoRNP complex TAS
    Traceable Author Statement
    more info
    PubMed 
    box H/ACA telomerase RNP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    box H/ACA telomerase RNP complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    box H/ACA telomerase RNP complex TAS
    Traceable Author Statement
    more info
    PubMed 
    nuclear body IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    small nucleolar ribonucleoprotein complex TAS
    Traceable Author Statement
    more info
    PubMed 
    telomerase holoenzyme complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    telomerase holoenzyme complex TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    H/ACA ribonucleoprotein complex subunit 3
    Names
    NOP10 ribonucleoprotein homolog
    homolog of yeast Nop10p
    nucleolar protein 10
    nucleolar protein family A member 3
    nucleolar protein family A, member 3 (H/ACA small nucleolar RNPs)
    snoRNP protein NOP10

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_011562.1 RefSeqGene

      Range
      5001..6446
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_345

    mRNA and Protein(s)

    1. NM_018648.3NP_061118.1  H/ACA ribonucleoprotein complex subunit 3

      See identical proteins and their annotated locations for NP_061118.1

      Status: REVIEWED

      Source sequence(s)
      BM554889, BQ218536
      Consensus CDS
      CCDS10037.1
      UniProtKB/Swiss-Prot
      Q9NPE3
      Related
      ENSP00000332198.4, ENST00000328848.5
      Conserved Domains (1) summary
      pfam04135
      Location:652
      Nop10p; Nucleolar RNA-binding protein, Nop10p family

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

      Range
      34341716..34343161 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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