U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    MCM10 minichromosome maintenance 10 replication initiation factor [ Homo sapiens (human) ]

    Gene ID: 55388, updated on 8-Jan-2023

    Summary

    Official Symbol
    MCM10provided by HGNC
    Official Full Name
    minichromosome maintenance 10 replication initiation factorprovided by HGNC
    Primary source
    HGNC:HGNC:18043
    See related
    Ensembl:ENSG00000065328 MIM:609357; AllianceGenome:HGNC:18043
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CNA43; DNA43; IMD80; PRO2249
    Summary
    The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre-RC) and it may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein can interact with MCM2 and MCM6, as well as with the origin recognition protein ORC2. It is regulated by proteolysis and phosphorylation in a cell cycle-dependent manner. Studies of a similar protein in Xenopus suggest that the chromatin binding of this protein at the onset of DNA replication is after pre-RC assembly and before origin unwinding. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in bone marrow (RPKM 2.8), lymph node (RPKM 2.2) and 15 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See MCM10 in Genome Data Viewer
    Location:
    10p13
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    110 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (13161558..13211110)
    110 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (13176180..13225648)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (13203558..13253110)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene BTB domain containing 7 pseudogene 1 Neighboring gene ribosomal protein L36a pseudogene 36 Neighboring gene Sharpr-MPRA regulatory region 2216 Neighboring gene RNA, U6 small nuclear 6, pseudogene Neighboring gene upper zone of growth plate and cartilage matrix associated

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Vpr vpr HIV-1 depletes MCM10 in a Vpr-dependent manner PubMed
    vpr HIV-1 Vpr enhances the proteasomal degradation of MCM10, (a natural substrate for the Cul4-DDB1[VprBP] E3 ubiquitin ligase whose degradation is regulated by VprBP), by interacting with VprBP PubMed
    vpr HIV-1 Vpr degrades MCM10 via Cul4-DDB1 E3 ubiquitin ligase proteasomal degradation pathway PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC126776

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA replication origin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables enzyme binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables single-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in DNA replication initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in DNA replication initiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to DNA damage stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in nuclear replication fork IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 

    General protein information

    Preferred Names
    protein MCM10 homolog
    Names
    MCM10 minichromosome maintenance deficient 10
    homolog of yeast MCM10
    hsMCM10
    minichromosome maintenance complex component 10

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_018518.5NP_060988.3  protein MCM10 homolog isoform 2

      See identical proteins and their annotated locations for NP_060988.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) encodes the predominant isoform (2).
      Source sequence(s)
      AB042719, AL136840, AL138764, DA024424
      Consensus CDS
      CCDS7095.1
      UniProtKB/Swiss-Prot
      Q7L590
      Related
      ENSP00000367986.3, ENST00000378714.8
      Conserved Domains (2) summary
      pfam09329
      Location:381426
      zf-primase; Primase zinc finger
      pfam09332
      Location:525872
      Mcm10; Mcm10 replication factor
    2. NM_182751.3NP_877428.1  protein MCM10 homolog isoform 1

      See identical proteins and their annotated locations for NP_877428.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) uses a different splice site, compared to variant 2, that results in a longer isoform (1). Though this variant is supported by EST data, the existence of its encoded isoform has not been experimentally verified.
      Source sequence(s)
      AB042719, AK055695, AL136840, AL138764, DA024424
      Consensus CDS
      CCDS7096.1
      UniProtKB/Swiss-Prot
      Q7L590, Q9P177
      Related
      ENSP00000418268.1, ENST00000484800.6
      Conserved Domains (2) summary
      pfam09329
      Location:382427
      zf-primase; Primase zinc finger
      pfam09332
      Location:526873
      Mcm10; Mcm10 replication factor

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      13161558..13211110
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011519538.3XP_011517840.1  protein MCM10 homolog isoform X1

      See identical proteins and their annotated locations for XP_011517840.1

      UniProtKB/Swiss-Prot
      Q7L590, Q9P177
      Conserved Domains (2) summary
      pfam09329
      Location:382427
      zf-primase; Primase zinc finger
      pfam09332
      Location:526873
      Mcm10; Mcm10 replication factor
    2. XM_047425437.1XP_047281393.1  protein MCM10 homolog isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      13176180..13225648
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)