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    LRRC59 leucine rich repeat containing 59 [ Homo sapiens (human) ]

    Gene ID: 55379, updated on 17-Jun-2019

    Summary

    Official Symbol
    LRRC59provided by HGNC
    Official Full Name
    leucine rich repeat containing 59provided by HGNC
    Primary source
    HGNC:HGNC:28817
    See related
    Ensembl:ENSG00000108829 MIM:614854
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    p34; PRO1855
    Expression
    Ubiquitous expression in colon (RPKM 47.1), stomach (RPKM 37.6) and 25 other tissues See more
    Orthologs

    Genomic context

    See LRRC59 in Genome Data Viewer
    Location:
    17q21.33
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (50381238..50397523, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (48458594..48474914, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene xylosyltransferase 2 Neighboring gene mitochondrial ribosomal protein L27 Neighboring gene essential meiotic structure-specific endonuclease 1 Neighboring gene acyl-CoA synthetase family member 2 Neighboring gene mitochondrial ribosomal protein S21 pseudogene 9 Neighboring gene chondroadherin

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify leucine rich repeat containing 59 (LRRC59), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify leucine rich repeat containing 59 (LRRC59), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Nef nef Tandem affinity purification and mass spectrometry analysis identify leucine rich repeat containing 59 (LRRC59), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify leucine rich repeat containing 59 (LRRC59), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ21675

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
     
    endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane HDA PubMed 
    mitochondrial nucleoid IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear envelope IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    leucine-rich repeat-containing protein 59
    Names
    ribosome-binding protein p34

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_018509.4NP_060979.2  leucine-rich repeat-containing protein 59

      See identical proteins and their annotated locations for NP_060979.2

      Status: VALIDATED

      Source sequence(s)
      AF119857, BC017168, DA782636
      Consensus CDS
      CCDS11566.1
      UniProtKB/Swiss-Prot
      Q96AG4
      Related
      ENSP00000225972.7, ENST00000225972.8
      Conserved Domains (3) summary
      COG4886
      Location:18120
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00031
      Location:1940
      LRR_1; leucine-rich repeat [structural motif]
      cl26407
      Location:135243
      IF-2; Translation-initiation factor 2

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

      Range
      50381238..50397523 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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