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    PIDD1 p53-induced death domain protein 1 [ Homo sapiens (human) ]

    Gene ID: 55367, updated on 17-Jun-2024

    Summary

    Official Symbol
    PIDD1provided by HGNC
    Official Full Name
    p53-induced death domain protein 1provided by HGNC
    Primary source
    HGNC:HGNC:16491
    See related
    Ensembl:ENSG00000177595 MIM:605247; AllianceGenome:HGNC:16491
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LRDD; PIDD; MRT75
    Summary
    The protein encoded by this gene contains a leucine-rich repeat and a death domain. This protein has been shown to interact with other death domain proteins, such as Fas (TNFRSF6)-associated via death domain (FADD) and MAP-kinase activating death domain-containing protein (MADD), and thus may function as an adaptor protein in cell death-related signaling processes. The expression of the mouse counterpart of this gene has been found to be positively regulated by the tumor suppressor p53 and to induce cell apoptosis in response to DNA damage, which suggests a role for this gene as an effector of p53-dependent apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2010]
    Expression
    Ubiquitous expression in testis (RPKM 3.7), spleen (RPKM 3.6) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See PIDD1 in Genome Data Viewer
    Location:
    11p15.5
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (799184..809501, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (850616..861222, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (799184..805231, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3029 Neighboring gene cell cycle exit and neuronal differentiation 1 Neighboring gene solute carrier family 25 member 22 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:794229-794747 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:795266-795784 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3032 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:796302-796820 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4279 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4280 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4281 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:797857-798373 Neighboring gene proapoptotic nucleolar protein 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:804161-804858 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3034 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4284 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4285 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4286 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3035 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:811306-812046 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:812047-812787 Neighboring gene ribosomal protein lateral stalk subunit P2 Neighboring gene small nucleolar RNA, H/ACA box 52 Neighboring gene Sharpr-MPRA regulatory region 11801 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3036 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4287 Neighboring gene patatin like phospholipase domain containing 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC16925, DKFZp434D229

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables death receptor binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    part_of endopeptidase complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    located_in nucleolus NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 

    General protein information

    Preferred Names
    p53-induced death domain-containing protein 1
    Names
    leucine-rich repeat and death domain-containing protein
    leucine-rich repeats and death domain containing
    p53-induced protein with a death domain

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145886.4NP_665893.2  p53-induced death domain-containing protein 1 isoform 1

      See identical proteins and their annotated locations for NP_665893.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AF274972, BQ214414, BX349115, CN427946
      Consensus CDS
      CCDS7716.1
      UniProtKB/Swiss-Prot
      Q59FD1, Q59H10, Q59HC7, Q7Z4P8, Q8NC89, Q8NDL2, Q96C25, Q9HB75, Q9NRE6
      Related
      ENSP00000337797.5, ENST00000347755.10
      Conserved Domains (6) summary
      cd00116
      Location:117279
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      cd08779
      Location:788873
      Death_PIDD; Death Domain of p53-induced protein with a death domain
      sd00033
      Location:127152
      LRR_RI; leucine-rich repeat [structural motif]
      pfam10461
      Location:421453
      Peptidase_S68; Peptidase S68
      pfam13855
      Location:194252
      LRR_8; Leucine rich repeat
      cl02517
      Location:325398
      ZU5; ZU5 domain
    2. NM_145887.4NP_665894.2  p53-induced death domain-containing protein 1 isoform 3

      See identical proteins and their annotated locations for NP_665894.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1, resulting in an isoform (3) that is shorter than isoform 1.
      Source sequence(s)
      BC014904, BQ059356, BX349115, CN427946
      Consensus CDS
      CCDS44508.1
      UniProtKB/Swiss-Prot
      Q9HB75
      Related
      ENSP00000416801.2, ENST00000411829.6
      Conserved Domains (7) summary
      cd00116
      Location:117279
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      cd08779
      Location:771856
      Death_PIDD; Death Domain of p53-induced protein with a death domain
      sd00033
      Location:127152
      LRR_RI; leucine-rich repeat [structural motif]
      pfam10461
      Location:421453
      Peptidase_S68; Peptidase S68
      pfam13855
      Location:194252
      LRR_8; Leucine rich repeat
      cl00467
      Location:666856
      Ntn_hydrolase; The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a ...
      cl02517
      Location:325398
      ZU5; ZU5 domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      799184..809501 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011520210.4XP_011518512.1  p53-induced death domain-containing protein 1 isoform X4

      See identical proteins and their annotated locations for XP_011518512.1

      UniProtKB/Swiss-Prot
      Q59FD1, Q59H10, Q59HC7, Q7Z4P8, Q8NC89, Q8NDL2, Q96C25, Q9HB75, Q9NRE6
      Conserved Domains (6) summary
      cd00116
      Location:117279
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      cd08779
      Location:788873
      Death_PIDD; Death Domain of p53-induced protein with a death domain
      sd00033
      Location:127152
      LRR_RI; leucine-rich repeat [structural motif]
      pfam10461
      Location:421453
      Peptidase_S68; Peptidase S68
      pfam13855
      Location:194252
      LRR_8; Leucine rich repeat
      cl02517
      Location:325398
      ZU5; ZU5 domain
    2. XM_005253005.6XP_005253062.1  p53-induced death domain-containing protein 1 isoform X2

      See identical proteins and their annotated locations for XP_005253062.1

      Conserved Domains (6) summary
      cd00116
      Location:117279
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      cd08779
      Location:812897
      Death_PIDD; Death Domain of p53-induced protein with a death domain
      sd00033
      Location:127152
      LRR_RI; leucine-rich repeat [structural motif]
      pfam10461
      Location:421453
      Peptidase_S68; Peptidase S68
      pfam13855
      Location:194252
      LRR_8; Leucine rich repeat
      cl02517
      Location:325398
      ZU5; ZU5 domain
    3. XM_011520209.4XP_011518511.1  p53-induced death domain-containing protein 1 isoform X3

      Conserved Domains (7) summary
      cd00116
      Location:144306
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      cd08779
      Location:798883
      Death_PIDD; Death Domain of p53-induced protein with a death domain
      sd00033
      Location:154179
      LRR_RI; leucine-rich repeat [structural motif]
      pfam10461
      Location:448480
      Peptidase_S68; Peptidase S68
      pfam13855
      Location:221279
      LRR_8; Leucine rich repeat
      cl00467
      Location:693883
      Ntn_hydrolase; The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a ...
      cl02517
      Location:352425
      ZU5; ZU5 domain
    4. XM_047427240.1XP_047283196.1  p53-induced death domain-containing protein 1 isoform X1

    5. XM_047427239.1XP_047283195.1  p53-induced death domain-containing protein 1 isoform X12

    6. XM_047427238.1XP_047283194.1  p53-induced death domain-containing protein 1 isoform X11

    7. XM_005253006.6XP_005253063.1  p53-induced death domain-containing protein 1 isoform X2

      See identical proteins and their annotated locations for XP_005253063.1

      Conserved Domains (6) summary
      cd00116
      Location:117279
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      cd08779
      Location:812897
      Death_PIDD; Death Domain of p53-induced protein with a death domain
      sd00033
      Location:127152
      LRR_RI; leucine-rich repeat [structural motif]
      pfam10461
      Location:421453
      Peptidase_S68; Peptidase S68
      pfam13855
      Location:194252
      LRR_8; Leucine rich repeat
      cl02517
      Location:325398
      ZU5; ZU5 domain
    8. XM_047427243.1XP_047283199.1  p53-induced death domain-containing protein 1 isoform X8

    9. XM_047427242.1XP_047283198.1  p53-induced death domain-containing protein 1 isoform X7

    10. XM_047427241.1XP_047283197.1  p53-induced death domain-containing protein 1 isoform X6

    11. XM_011520212.3XP_011518514.1  p53-induced death domain-containing protein 1 isoform X5

      See identical proteins and their annotated locations for XP_011518514.1

      Conserved Domains (6) summary
      cd08779
      Location:666751
      Death_PIDD; Death Domain of p53-induced protein with a death domain
      sd00033
      Location:726
      LRR_RI; leucine-rich repeat [structural motif]
      pfam10461
      Location:275307
      Peptidase_S68; Peptidase S68
      pfam12799
      Location:95134
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:48106
      LRR_8; Leucine rich repeat
      cl02517
      Location:179252
      ZU5; ZU5 domain
    12. XM_047427246.1XP_047283202.1  p53-induced death domain-containing protein 1 isoform X10

    13. XM_011520213.3XP_011518515.1  p53-induced death domain-containing protein 1 isoform X9

      Conserved Domains (3) summary
      cd08779
      Location:499584
      Death_PIDD; Death Domain of p53-induced protein with a death domain
      pfam10461
      Location:108140
      Peptidase_S68; Peptidase S68
      cl02517
      Location:1285
      ZU5; ZU5 domain
    14. XM_047427245.1XP_047283201.1  p53-induced death domain-containing protein 1 isoform X9

    15. XM_047427244.1XP_047283200.1  p53-induced death domain-containing protein 1 isoform X13

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      850616..861222 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054369310.1XP_054225285.1  p53-induced death domain-containing protein 1 isoform X2

    2. XM_054369312.1XP_054225287.1  p53-induced death domain-containing protein 1 isoform X4

    3. XM_054369309.1XP_054225284.1  p53-induced death domain-containing protein 1 isoform X1

    4. XM_054369311.1XP_054225286.1  p53-induced death domain-containing protein 1 isoform X3

    5. XM_054369314.1XP_054225289.1  p53-induced death domain-containing protein 1 isoform X2

    6. XM_054369308.1XP_054225283.1  p53-induced death domain-containing protein 1 isoform X14

    7. XM_054369318.1XP_054225293.1  p53-induced death domain-containing protein 1 isoform X8

    8. XM_054369317.1XP_054225292.1  p53-induced death domain-containing protein 1 isoform X7

    9. XM_054369316.1XP_054225291.1  p53-induced death domain-containing protein 1 isoform X6

    10. XM_054369315.1XP_054225290.1  p53-induced death domain-containing protein 1 isoform X5

    11. XM_054369322.1XP_054225297.1  p53-induced death domain-containing protein 1 isoform X10

    12. XM_054369321.1XP_054225296.1  p53-induced death domain-containing protein 1 isoform X9

    13. XM_054369320.1XP_054225295.1  p53-induced death domain-containing protein 1 isoform X9

    14. XM_054369313.1XP_054225288.1  p53-induced death domain-containing protein 1 isoform X15

    15. XM_054369319.1XP_054225294.1  p53-induced death domain-containing protein 1 isoform X16

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_018494.3: Suppressed sequence

      Description
      NM_018494.3: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.