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    SHFL shiftless antiviral inhibitor of ribosomal frameshifting [ Homo sapiens (human) ]

    Gene ID: 55337, updated on 17-Jun-2019

    Summary

    Official Symbol
    SHFLprovided by HGNC
    Official Full Name
    shiftless antiviral inhibitor of ribosomal frameshiftingprovided by HGNC
    Primary source
    HGNC:HGNC:25649
    See related
    Ensembl:ENSG00000130813 MIM:616808
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SFL; IRAV; RyDEN; C19orf66
    Expression
    Ubiquitous expression in liver (RPKM 17.9), spleen (RPKM 17.5) and 25 other tissues See more
    Orthologs

    Genomic context

    See SHFL in Genome Data Viewer
    Location:
    19p13.2
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (10086119..10093249)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (10196806..10203928)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene microRNA 5589 Neighboring gene complement component 3 precursor pseudogene Neighboring gene angiopoietin like 6 Neighboring gene PPAN-P2RY11 readthrough Neighboring gene small nucleolar RNA, C/D box 105 Neighboring gene small nucleolar RNA, C/D box 105B Neighboring gene peter pan homolog

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ11286, FLJ40743

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    defense response to virus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of viral genome replication IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to interferon-gamma IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to type I interferon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to type III interferon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    repressor of yield of DENV protein
    Names
    Repressor of yield of Dengue virus
    UPF0515 protein C19orf66
    interferon-regulated antiviral
    shiftless

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001308277.2NP_001295206.1  repressor of yield of DENV protein isoform 2

      See identical proteins and their annotated locations for NP_001295206.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
      Source sequence(s)
      BC026180, BC035817, DB481173
      Consensus CDS
      CCDS77231.1
      UniProtKB/Swiss-Prot
      Q9NUL5
      Related
      ENSP00000467182.1, ENST00000591813.5
      Conserved Domains (1) summary
      pfam15135
      Location:16232
      UPF0515; Uncharacterized protein UPF0515
    2. NM_018381.4NP_060851.2  repressor of yield of DENV protein isoform 1

      See identical proteins and their annotated locations for NP_060851.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK002148, BC010847, DB481173
      Consensus CDS
      CCDS45957.1
      UniProtKB/Swiss-Prot
      Q9NUL5
      Related
      ENSP00000253110.10, ENST00000253110.16
      Conserved Domains (1) summary
      pfam15135
      Location:16268
      UPF0515; Uncharacterized protein UPF0515

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

      Range
      10086119..10093249
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011528121.1XP_011526423.1  repressor of yield of DENV protein isoform X1

      Related
      ENSP00000380978.3, ENST00000397881.7
      Conserved Domains (1) summary
      pfam15135
      Location:27229
      UPF0515; uncharacterized protein UPF0515
    2. XM_011528122.1XP_011526424.1  repressor of yield of DENV protein isoform X2

      Conserved Domains (1) summary
      pfam15135
      Location:1685
      UPF0515; uncharacterized protein UPF0515
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