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    TMEM74B transmembrane protein 74B [ Homo sapiens (human) ]

    Gene ID: 55321, updated on 29-Mar-2018

    Summary

    Official Symbol
    TMEM74Bprovided by HGNC
    Official Full Name
    transmembrane protein 74Bprovided by HGNC
    Primary source
    HGNC:HGNC:15893
    See related
    Ensembl:ENSG00000125895 Vega:OTTHUMG00000031655
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C20orf46
    Expression
    Broad expression in small intestine (RPKM 4.2), lung (RPKM 3.7) and 21 other tissues See more
    Orthologs

    Genomic context

    See TMEM74B in Genome Data Viewer
    Location:
    20p13
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 20 NC_000020.11 (1180561..1188138, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (1161213..1166077, complement)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372493 Neighboring gene proteasome inhibitor subunit 1 Neighboring gene actin gamma 1 pseudogene 3 Neighboring gene uncharacterized LOC105372496 Neighboring gene chromosome 20 open reading frame 202 Neighboring gene RAD21 cohesin complex component like 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ11190, FLJ44889

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    transmembrane protein 74B
    Names
    transmembrane protein C20orf46

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001304748.1NP_001291677.1  transmembrane protein 74B isoform 1

      See identical proteins and their annotated locations for NP_001291677.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AA861530, AK002052, AL031665, BM545116
      Consensus CDS
      CCDS13011.1
      UniProtKB/Swiss-Prot
      Q9NUR3
      Conserved Domains (1) summary
      PRK14954
      Location:15175
      PRK14954; DNA polymerase III subunits gamma and tau; Provisional
    2. NM_001304749.1NP_001291678.1  transmembrane protein 74B isoform 2

      See identical proteins and their annotated locations for NP_001291678.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.
      Source sequence(s)
      AA861530, AK002052, AL031665, AW628999
      UniProtKB/Swiss-Prot
      Q9NUR3
      Conserved Domains (1) summary
      pfam14927
      Location:99164
      Neurensin; Neurensin
    3. NM_018354.2NP_060824.1  transmembrane protein 74B isoform 1

      See identical proteins and their annotated locations for NP_060824.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AA861530, AK002052, BC126988
      Consensus CDS
      CCDS13011.1
      UniProtKB/Swiss-Prot
      Q9NUR3
      Related
      ENSP00000371318.3, OTTHUMP00000029949, ENST00000381894.3, OTTHUMT00000077496
      Conserved Domains (1) summary
      PRK14954
      Location:15175
      PRK14954; DNA polymerase III subunits gamma and tau; Provisional

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p12 Primary Assembly

      Range
      1180561..1188138 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011529281.2XP_011527583.1  transmembrane protein 74B isoform X1

      Conserved Domains (1) summary
      COG5182
      Location:66168
      CUS1; Splicing factor 3b, subunit 2 [RNA processing and modification]
    2. XM_017027923.1XP_016883412.1  transmembrane protein 74B isoform X2

    3. XM_011529285.2XP_011527587.1  transmembrane protein 74B isoform X4

      See identical proteins and their annotated locations for XP_011527587.1

      Conserved Domains (1) summary
      pfam14927
      Location:99164
      Neurensin; Neurensin
    4. XM_017027924.1XP_016883413.1  transmembrane protein 74B isoform X3

      UniProtKB/Swiss-Prot
      Q9NUR3
      Conserved Domains (1) summary
      PRK14954
      Location:15175
      PRK14954; DNA polymerase III subunits gamma and tau; Provisional
    5. XM_011529282.2XP_011527584.1  transmembrane protein 74B isoform X3

      See identical proteins and their annotated locations for XP_011527584.1

      UniProtKB/Swiss-Prot
      Q9NUR3
      Conserved Domains (1) summary
      PRK14954
      Location:15175
      PRK14954; DNA polymerase III subunits gamma and tau; Provisional
    6. XM_011529283.2XP_011527585.1  transmembrane protein 74B isoform X3

      See identical proteins and their annotated locations for XP_011527585.1

      UniProtKB/Swiss-Prot
      Q9NUR3
      Conserved Domains (1) summary
      PRK14954
      Location:15175
      PRK14954; DNA polymerase III subunits gamma and tau; Provisional
    7. XM_011529284.2XP_011527586.1  transmembrane protein 74B isoform X3

      See identical proteins and their annotated locations for XP_011527586.1

      UniProtKB/Swiss-Prot
      Q9NUR3
      Conserved Domains (1) summary
      PRK14954
      Location:15175
      PRK14954; DNA polymerase III subunits gamma and tau; Provisional
    8. XM_017027925.1XP_016883414.1  transmembrane protein 74B isoform X4

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