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    RNF121 ring finger protein 121 [ Homo sapiens (human) ]

    Gene ID: 55298, updated on 17-Jun-2019

    Summary

    Official Symbol
    RNF121provided by HGNC
    Official Full Name
    ring finger protein 121provided by HGNC
    Primary source
    HGNC:HGNC:21070
    See related
    Ensembl:ENSG00000137522
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. Several alternatively spliced transcript variants have been noted for this gene, however, not all are likely to encode viable protein products. [provided by RefSeq, Sep 2008]
    Expression
    Ubiquitous expression in kidney (RPKM 7.3), thyroid (RPKM 7.2) and 25 other tissues See more
    Orthologs

    Genomic context

    See RNF121 in Genome Data Viewer
    Location:
    11q13.4
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (71928701..71997597)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (71639768..71708643)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene transient receptor potential cation channel, subfamily C, member 2-like Neighboring gene olfactory receptor family 7 subfamily E member 128 pseudogene Neighboring gene olfactory receptor family 7 subfamily E member 126 pseudogene Neighboring gene uncharacterized LOC100128494 Neighboring gene interleukin 18 binding protein Neighboring gene nuclear mitotic apparatus protein 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ11099

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    endoplasmic reticulum unfolded protein response IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin-dependent ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001300926.1NP_001287855.1  RING finger protein 121 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks two alternate exons and uses an alternate splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (b) has shorter and distinct N- and C-termini compared to isoform a.
      Source sequence(s)
      AL833638, AP002490, DA209781
      Consensus CDS
      CCDS73343.1
      UniProtKB/TrEMBL
      C9JQY5
      Related
      ENSP00000377316.3, ENST00000393713.7
    2. NM_018320.5NP_060790.2  RING finger protein 121 isoform a

      See identical proteins and their annotated locations for NP_060790.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a).
      Source sequence(s)
      AI291325, AK023139, AL833638, AP002490, CN392009, DA209781
      Consensus CDS
      CCDS8203.1
      UniProtKB/Swiss-Prot
      Q9H920
      Related
      ENSP00000354571.3, ENST00000361756.8
      Conserved Domains (1) summary
      cd16475
      Location:224278
      RING-H2_RNF121_like; RING finger, H2 subclass, found in RING finger proteins RNF121, RNF175 and similar proteins

    RNA

    1. NR_024147.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) is missing an internal coding exon compared to transcript variant 1. If translation initiates at the same codon as used in variant 1, then this results in a frame-shift and premature translation termination, rendering the transcript susceptible to nonsense-mediated mRNA decay (NMD). Although a putative alternate AUG site is observed in a different frame downstream of the standard AUG site, it is not likely to be used because it is located within the short ORF available with the standard AUG site (as defined by variant 1). Therefore, the transcript is represented as a non-protein-coding RefSeq.
      Source sequence(s)
      AI291325, AK023139, AL833638, AP002490, CN392009, DA209781
      Related
      ENST00000530137.1
    2. NR_024148.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) is missing an internal coding exon and also includes an additional exon compared to transcript variant 1. This results in a frame-shift and premature translation termination, rendering the transcript susceptible to nonsense-mediated mRNA decay (NMD). There are no other likely translation initiation sites and so the transcript is represented as a non-protein-coding RefSeq.
      Source sequence(s)
      AI291325, AK023139, AK094508, AL833638, AP002490, CN392009, DA209781, DA694800
      Related
      ENST00000526549.5

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

      Range
      71928701..71997597
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006718629.1XP_006718692.1  RING finger protein 121 isoform X1

      See identical proteins and their annotated locations for XP_006718692.1

      Conserved Domains (1) summary
      pfam13639
      Location:190240
      zf-RING_2; Ring finger domain
    2. XM_006718632.1XP_006718695.1  RING finger protein 121 isoform X3

      See identical proteins and their annotated locations for XP_006718695.1

      Conserved Domains (1) summary
      pfam13639
      Location:119169
      zf-RING_2; Ring finger domain
    3. XM_011545150.1XP_011543452.1  RING finger protein 121 isoform X2

      See identical proteins and their annotated locations for XP_011543452.1

      UniProtKB/Swiss-Prot
      Q9H920
      Conserved Domains (1) summary
      pfam13639
      Location:145195
      zf-RING_2; Ring finger domain
    4. XM_006718630.1XP_006718693.1  RING finger protein 121 isoform X2

      See identical proteins and their annotated locations for XP_006718693.1

      UniProtKB/Swiss-Prot
      Q9H920
      Conserved Domains (1) summary
      pfam13639
      Location:145195
      zf-RING_2; Ring finger domain
    5. XM_024448604.1XP_024304372.1  RING finger protein 121 isoform X4

      Conserved Domains (1) summary
      cd16475
      Location:96150
      RING-H2_RNF121_like; RING finger, H2 subclass, found in RING finger proteins RNF121, RNF175 and similar proteins

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_194452.1: Suppressed sequence

      Description
      NM_194452.1: This RefSeq was permanently suppressed because it was annotated with an overlapping downstream ORF when an upstream ORF existed. However, use of the upstream AUG will render this transcript susceptible to nonsense-mediated mRNA decay (NMD).
    2. NM_194453.1: Suppressed sequence

      Description
      NM_194453.1: This RefSeq was permanently suppressed because it was annotated with an overlapping downstream ORF when an upstream ORF existed. However, use of the upstream AUG will render this transcript susceptible to nonsense-mediated mRNA decay (NMD).
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