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    BRF2 BRF2 RNA polymerase III transcription initiation factor subunit [ Homo sapiens (human) ]

    Gene ID: 55290, updated on 17-Jun-2019

    Summary

    Official Symbol
    BRF2provided by HGNC
    Official Full Name
    BRF2 RNA polymerase III transcription initiation factor subunitprovided by HGNC
    Primary source
    HGNC:HGNC:17298
    See related
    Ensembl:ENSG00000104221 MIM:607013
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BRFU; TFIIIB50
    Summary
    This gene encodes one of the multiple subunits of the RNA polymerase III transcription factor complex required for transcription of genes with promoter elements upstream of the initiation site. The product of this gene, a TFIIB-like factor, is directly recruited to the TATA-box of polymerase III small nuclear RNA gene promoters through its interaction with the TATA-binding protein. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in fat (RPKM 46.9), prostate (RPKM 42.0) and 24 other tissues See more
    Orthologs

    Genomic context

    See BRF2 in Genome Data Viewer
    Location:
    8p11.23
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (37843268..37849861, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (37701398..37707431, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105379381 Neighboring gene adhesion G protein-coupled receptor A2 Neighboring gene VISTA enhancer hs1665 Neighboring gene RAB11 family interacting protein 1 Neighboring gene RNA, 7SL, cytoplasmic 709, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    NHGRI GWAS Catalog

    Description
    Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error.
    NHGRI GWA Catalog

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ11052

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    RNA polymerase III type 3 promoter DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RNA polymerase III type 3 promoter sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    transcription factor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    DNA-templated transcription, initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    RNA polymerase III preinitiation complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cellular response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of transcription by RNA polymerase III IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transcription factor TFIIIB complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transcription factor TFIIIB complex IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 

    General protein information

    Preferred Names
    transcription factor IIIB 50 kDa subunit
    Names
    B-related factor 2
    BRF-2
    BRF2, RNA polymerase III transcription initiation factor 50 kDa subunit
    BRF2, subunit of RNA polymerase III transcription initiation factor, BRF1-like
    RNA polymerase III transcription initiation factor BRFU
    hBRFU
    hTFIIIB50
    transcription factor IIB- related factor, TFIIIB50

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_046965.1 RefSeqGene

      Range
      5001..11034
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_018310.4NP_060780.2  transcription factor IIIB 50 kDa subunit

      See identical proteins and their annotated locations for NP_060780.2

      Status: REVIEWED

      Source sequence(s)
      AA496239, AC138356, AF206673, AK001914
      Consensus CDS
      CCDS6098.1
      UniProtKB/Swiss-Prot
      Q9HAW0
      Related
      ENSP00000220659.6, ENST00000220659.10
      Conserved Domains (1) summary
      COG1405
      Location:5233
      SUA7; Transcription initiation factor TFIIIB, Brf1 subunit/Transcription initiation factor TFIIB [Transcription]

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

      Range
      37843268..37849861 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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